IMANOK Isotretinoin 10mg CPC1HN treatment of severe acne (2 blisters x 15 tablets)

Dosage form Box of 2 blisters x 15 tablets
Specifications Isotretinoin

Ingredient

Composition information	Content
Isotretinoin	10mg

Uses

indications

IMANOK drugs are indicated in the following cases:

Treatment of severe forms of acne systems without responding to other previous treatments, especially acne -shaped acne. Isotretinoin is also indicated to treat Gram -negative bacteria in hair follicles, some cases of red acne and infection inflammation. Isotretinoin may also have the effect of repairing serious keratin disorders such as congenital fish scales, red skin, fish scales (thin films or other types of fish scales), horny folliculitis (Daric), Horn Horn with feet, hair scales (PRD).

Pharmacokological

isotretinoin is a stereoisomer of retinoic acid. Clinical research shows that isotretinoin helps improve acne -related acne -related acne and time inhibits the activity of sebaceous glands and reduces the size of the sebum pipe.

pharmacokinetics

absorption:

Isotretinoin is better absorbed through the gastrointestinal tract when used with high -fat foods. Both peak concentrations in plasma (CMAX) and the absorption concentration (AUC) of Isotretinoin have doubled after a high -fat meal compared to isotretinoin in fasting conditions.

distribution:

more than 99.9% of the drug is associated with plasma proteins and mainly albumin. The drug can pass the placenta fence. It is not clear whether Isotretinoin is distributed into breast milk.

transformation:

Isotretinoin is metabolized in the liver and may be in the small intestine wall. At least 3 metabolites found in plasma: 4-oxo-isotretinoin, retinoic acid (tretinoin) and 4- Oxouxit-Retinoic (4-oxotretinoin).

Main metabolites found in urine in the form of 4-olo-isotretinoin.

In vitro research shows that the main P450 isotropic participation in the metabolism of isotretinoin is 2C8, 2C9, 3A4 and 2B6. Isotretinoin and its metabolites continue to convert into combinations and are excreted through feces and urine.

excretion:

The metabolites of isotretinoin are excreted in feces and urine (65% to 83%). After giving 74 healthy adults the single dose of 80 mg isotretinoin with food, the average selling time of isotretinoin and 4-oxo-isotretinoin found corresponding to 21.0 ± 8.2 hours and 24.0-5.3 hours. The ratio of Isotretinoin accumulation increased to 0.90% to 5.43% when used from the second dose in patients with acne.

Before taking IMANOK Isotretinoin 10mg CPC1HN treatment of severe acne (2 blisters x 15 tablets)

How to use

tablets, oral use. Drugs should be taken at meals. Do not chew tablets. Avoid direct contact with sun photos and do not drink alcohol during medication.

Dosage

Patients with acne, follicular infections, inflammation of the infection and severe horny disorders:

Dosage of treatment should start at 0.5 to 1 mg/kg of weight daily divided into 2 times for 15 to 20 weeks. The maximum dose is 2mg/kg of weight per day for patients in the state of acne very severe or the disease starts in the chest or back. Treatment should be discontinued within 2 months before reuse.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Need to wash stomach early.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using iManok, you may experience unwanted effects (ADR) such as:

Most of the side effects when using isotretinoin are related to the dose. The reward side effects are reported as symptoms related to the overdose of vitamin A. Unwanted symptoms include:

Skin symptoms: Dry skin, sensitive to light.

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

IMANOK drugs contraindicated in the following cases:

Patients with liver function and renal function, vitamin A poisoning patients, patients with hyperlemia, patients with hypersensitivity to isotretinoin.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Isotretinoin is a highly capable of giving birth. Therefore, do not use iManok for pregnant women or intended to get pregnant. Patients need to be examined to eliminate pregnancy 4 weeks before treatment with isotretinoin. It is necessary to use continuous contraceptive measures within 1 month before treatment, during treatment and 1 month after stopping the use of the drug. period. Alcohol, lipid metabolic disorders, regular checkups for subclinical parameters if necessary.

The effect of the drug on the ability to drive and operate machinery

Precautions during the use of drugs with people who are driving and operating machinery.

Use drugs for women during pregnancy and lactation

Pregnancy

Do not use isotretinoin for pregnant women, intend to get pregnant or be able to get pregnant. Isotretinoin causes heavy birth defects. Use birth control pills and pregnancy tests before starting treatment and monthly during treatment.

Do not get pregnant at least 1 month after stopping isotretinom.

Breastfeeding period

Do not use isotretinoin for nursing women.

Interactive drug

Unsonized simultaneously imanok with drugs such as vitamin A, minocyclin, tetracycline and alcohol. Stop using Benzoyl Peroxid, Sulfur, Tretinoin or topical skin to treat the whole pieces before starting treatment with isotretinoin.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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