IMDUR 30mg Astrazeneca medicine for prophylactic treatment (2 blisters x 15 tablets)

Dosage form Box of 2 blisters x 15 tablets
Specifications Isosorbide-5-Mononitrate

Ingredient

Composition information	Content
Isosorbide-5-Mononitrate	30mg

Uses

indications

IMDUR 30 mg drugs are indicated for prophylactic treatment.

Pharmacology

The main pharmacological activity of Isosorbid-5-Mononitrate, the active metabolites of Isosorbid Dinitrate, is to dilate blood vessel smooth muscles, leading to venous dilatation and arteries but the varicose veins.

Treatment effect depends on the dose of use. Low concentration in plasma has the effect of varicose veins, leading to peripheral blood hyperplasia, reducing veins and reducing pressure at the end of the centrifugal diastolic ventricular (load).

The high concentration of drugs in plasma also relaxes the arteries, thus reducing blood vessel resistance and blood pressure, leading to post -load reduction.

Isosorbid-5-Mononitrate also works to directly relax coronary artery. By reducing the volume and pressure at the end of the diastolic period, the drug reduces the pressure in the heart muscle wall, thus improving the blood flow under the endothelium. Therefore, the synthetic effect of Isosorbid-5-Mononitrate is to reduce the card for the heart and improve the supply/demand balance for the heart muscle.

In control of a placebo, the only IMDUR dose of the day has been proved to be effective in controlling angina in terms of increasing exertion and improving symptoms, as well as reducing signs of myocardial ischemia. The impact time lasts at least 12 hours. At this time, the drug concentration in plasma is similar to the concentration of the drug 1 hour after taking the drug, about 1300 nmol/l.

IMDUR is effective in monatlearization as well as when combined with calcium channel blockers and beta receptor inhibitors.

The clinical effect of nitrate can be reduced when used repeated due to the high and prolonged plasma concentration. This can be avoided by allowing for a period of time between use that the drug concentration in plasma is low. When using IMDUR a single dose/day in the morning, the concentration of drugs in plasma is high during the day and low at night.

With 60 mg of IMDUR a single dose of the day, there is no drug that has anti -angina effect. With IMDUR, there is no observation of angina due to the reaction between the use as described for nitrate stickers.

Dynamic pharmacokinetics

absorption

Isosorbid-5-Mononitrate is completely absorbed and not metabolized in the early stages through the liver. The absorption is not significantly affected by food. The maximum concentration of drugs in plasma (about 3000 nmol/l) is reached about 4 hours after repeating the only oral dose of 60 mg/day. The concentration of drugs in plasma decreases to about 500 nmol/l at the end of the dose (24 hours after taking the drug).

distribution

The distribution integral of isosorbid-5-Mononitrate is about 0.6 l/kg.

Elimination

Complete clearance is approximately 115 ml/min. Selling time is about 5 hours. The excretion occurs due to the reduction of nitrogen and the conjugate reaction. The metabolites are excreted mainly through the kidneys. Only about 2% of the dose is excreted in the form of constant kidneys.

Before taking IMDUR 30mg Astrazeneca medicine for prophylactic treatment (2 blisters x 15 tablets)

How to use

IMDUR drugs can be used or not shared with food. 30 mg tablets have grooves and can be broken in half. All or ½ tablets are not chewed or crushed and should be taken with ½ glass of water.

Dosage

The usual dose is 60 mg, 1 time/day in the morning. The dose may increase to 120 mg/day for 1 time in the morning. To minimize the possibility of headache, the starting dose may be reduced to 30 mg/day for the first 2-4 days.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? The more severe symptoms are stimulating, blushing, cold sweating, nausea, vomiting, dizziness, fainting, fast heartbeat and hypotension.

Handling: Causing vomiting, using activated carbon by oral. In the case of severe hypotension, the patient should first be placed in a lying position, high legs. Intravenous infusion, if necessary.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using IMDUR 30mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Cardiovascular system: Hypotension, tachycardia.

Central nervous system: headache, dizziness.

Digestive system: Nausea.

Uncommon, 1/1000

Digestive system: vomiting, diarrhea.

rare, 1/10000

Central nervous system: fainting.

Mechanical system: muscle pain.

skin: rash, itching.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

IMDUR 30 mg contraindicated drug in the following cases:

There is a history of hypersensitivity to active ingredients or any excipients.

shock, hypotension, obstruction of myocardial disease and pericarditis, aortic valve stenosis, severe anemia, right heart attack.

Patients who are being treated with IMDUR 30 mg are not used inhibitors inhibitors phosphodiesterase type 5 (such as: sildenafil).

Be cautious when using

Caution should be careful to monitor patients with severe atherosclerosis and hypotension.

The ability to drive and operate machinery

Patients may get dizzy when using IMDUR 30 mg for the first time. Patients should determine the effects of IMDUR for themselves before driving or operating the machine.

Pregnancy

Safety and effectiveness of IMDUR 30 mg during pregnancy has not been determined.

Lactation period

The safety and effectiveness of IMDUR 30 mg during breastfeeding has not been determined.

Drug interaction

drug interactions may affect the activity of the drug or cause side effects. Should notify the doctor or pharmacist a list of drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

Simultaneous use of imdur and enamel inhibitor phosphodiesterase 5 can increase the vasodilation effect of IMDUR, which can lead to severe adverse effects such as fainting or myocardial infarction.

Storage

Store temperatures below 30⁰C.

To be out of reach of children.

Other drugs

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