IMDUR 60mg Astrazeneca medicine for prophylactic treatment (2 blisters x 15 tablets)

Dosage form Box of 2 blisters x 15 tablets
Specifications Isosorbide-5-Mononitrate

Ingredient

Composition information	Content
Isosorbide-5-Mononitrate	60mg

Uses

indicated

IMDUR is indicated for prophylactic treatment.

Pharmacokology

The main pharmacological activity of Isosorbid - 5 - Mononitrate, the active metabolitus of Isosorbid Dinitrate, is to relax blood vessel muscles, leading to venous and artery relaxation, superior varicose veins.

Treatment effect depends on the dose of use. The low concentration of drugs in plasma has the effect of varicose veins, resulting in peripheral blood hyperplasia, reducing venous blood reflection and reducing the end of the left ventricular diastolic (load). The high concentration of drugs in plasma also relaxes the arteries, thus reducing blood vessel resistance and blood pressure, leading to post -load reduction.

Isosorbid - 5 - Mononitrate also works directly to relax coronary artery. By reducing the volume and pressure at the end of the diastolic period, the drug reduces the pressure in the heart muscle wall, thus improving the blood flow under the endothelium. Therefore, the synthetic effect of Isosorbid - 5 - Mononitrate is to reduce the card for the heart and improve the supply/demand oxygen balance for the heart muscle.

In control of a placebo, the only IMDUR dose of the day has been proved to be effective in controlling angina in terms of increased exertion and improvement of symptoms, as well as reducing signs of myocardial ischemia.

The impact time lasts at least 12 hours. At this time, the drug concentration in plasma is similar to the concentration of the drug 1 hour after taking the drug, about 1300nmol/l.

IMDUR is effective in monatlearization as well as when combined with calcium channel blockers and receptor inhibitors.

The clinical effect of nitrate can be reduced when used repeated due to the high and prolonged plasma concentration. This can be avoided by allowing for a period of time between use that the drug concentration in plasma is low. When using IMDUR a single dose of the day in the morning, the drug concentration in plasma is high during the day and low at night.

With 60mg of only doses of IMDUR, there is no drug that has an anti -angina effect. With IMDUR, there is no observation of angina due to the reaction between the use as described for nitrate stickers.

pharmacokinetics

isosorbid - 5 - mononitrate is completely absorbed and not metabolized in the early stages through the liver. This reduces the variation of plasma concentrations in each individual and between individuals, and also leads to stable clinical effects that can be predicted.

Selling waste time of isosorbid - 5 - Mononitrate is about 5 hours. The distribution voltage of isosorbid-5-Mononitrate is about 0.6 l/kg and the total clearance of approximately 115 ml/min. The excretion occurs due to the reduction of nitrogen and the conjugate reaction. The metabolites are excreted mainly through the kidneys. Only about 2% of the dose is excreted in the form of constant kidneys.

Damage to liver or kidney function does not significantly affect the pharmacokinetic properties of IMDUR. IMDUR is the extended form of Durules (Durules) of Isosorbid - 5 - Mononitrate. The main active ingredient is released regardless of pH, within 10 hours.

Comparison with conventional tablets, the absorption stage of the IMDUR is prolonged and the impact time also lasts. The prolonged bioavailability of IMDUR is approximately 90% compared to instant release tablets.

The absorption is not significantly affected by food. Maximum drug concentration in plasma (about 3000 nmol/l) is reached about 4 hours after repeating the only oral dose of 60mg/day. The concentration of drugs in plasma decreases to about 500 nmol/l at the end of the dose (24 hours after taking the drug).

Before taking IMDUR 60mg Astrazeneca medicine for prophylactic treatment (2 blisters x 15 tablets)

How to use

IMDUR 30mg and 60mg tablets have grooves and can be broken in half. All or 1/2 tablets are not chewed or crushed and should be taken with 1/2 glass of water.

Dosage

recommended dose: Take the dose of 60mg, 1 time/day in the morning. The dose may increase to 120mg/day, use 1 time in the morning.

To minimize the possibility of headache, the starting dose may be reduced to 30mg/day for the first 2-4 days. Can be used or not shared with food.

IMDur is not indicated to reduce acute angina. In this case, nitroglycerin should be used under the tongue or in the mouth or in the form of sprays.

Matrix structure is not dissolved but decay when the active ingredient is released. Sometimes, this Matrix structure can pass through the digestive system without decaying and can be seen in feces. However, this does not show that the drug has been reduced.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Damage headache. The more severe symptoms are stimulating, blushing, cold sweating, nausea, vomiting, dizziness, fainting, fast heartbeat and hypotension.

Handling

Causes vomiting, using activated carbon by oral. In the case of severe hypotension, the patient should first be placed in a lying position, high legs. Intravenous infusion, if necessary.

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using IMDUR 60mg, you may experience unwanted effects (ADR).

Most of the adverse adverse reactions are related to pharmacological and dependent doses. Headache can occur at the beginning of treatment and often disappear when continuing treatment. Hypotension, with symptoms such as dizziness and nausea with fainting occasionally recorded. These symptoms often disappear when continuing treatment.

Definition of frequencies that appear adverse reactions: very common (> 10%), common (1 - 9.9%), rare (0.1 - 0.9%), rare (0.01 - 0.09%) and very rare (

cardiovascular system

Common: Hypotension, tachycardia.

Central nervous system

Common: headache, dizziness.

Rare: fainting.

Common: Nausea.

Very rare: muscle pain.

Rare: rash, itching.

Warnings

Contraindicated

IMDUR 60mg contraindications for the following cases:

There is a history of hypersensitivity to the active ingredient or any excipient, shock, hypotension, obstruction of myocardial disease and pericardial inflammation, aortic valve stenosis, severe blood deficiency, right myocardial infarction.

Be cautious when using

Caution should be careful to monitor patients with severe atherosclerosis and hypotension.

During pregnancy or lactation

The safety and effectiveness of IMDUR during pregnancy and breastfeeding have not been determined.

The ability to drive and operate machinery

Patients may get dizzy when using IMDUR for the first time. Patients should determine the influence of IMDUR for themselves before driving or operating the machine.

Medicinal interaction

Simultaneous use of imdur and enzyme inhibitors of tubes 5 can increase the impact of Imdur vasodilation, which is likely to lead to severe adverse effects such as fainting or myocardial infarction. Do not simultaneously use imdur and enzyme inhibitors (like sildenafil).

The effect of food on the absorption of IMDur is not clinically significant.

Storage

No storage above 30 ° C.

Expiry date: 3 years from the date of production.

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