Imexofen 180 Imexpharm medicine reduces chronic urticaria (3 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 3 blisters x 10 tablets
Ingredient Fexofenadin hydrochlorid
Indication Allergic rhinitis, urticaria, itching, allergic conjunctivitis
Contraindication Chronic renal failure

Ingredient

Composition information	Content
Fexofenadin hydrochlorid	180mg

Uses

indications

Imexofen 180 drugs are indicated to reduce the symptoms of chronic urticaria in adults and children aged 12 and older.

Pharmacokic

Fexofenadin is a second -generation antihistamine drug, which has a specific antagonistic and selective effect on peripheral H1 receptors. Fexofenadin is an active metabolite of terfenadin but no longer toxic to the heart due to not inhibiting potassium channels associated with myocardial cycles. Fexofenadin has no significant effect on acetylcholin antagonism, dopamine antagonism and has no effect of inhibiting Alpha 1 or Beta - Adrenergic receptor receptors. At the treatment dose, the drug does not cause sleep or affects the central nervous system.

The drug has a fast and prolonged effect due to the slow -attached drug to the H1 receptor forming a sustainable complex and separating slowly.

Dynamic pharmacokinetics

Good absorption drug when taken orally. After drinking, the peak concentration of the blood in the blood is reached after 2-3 hours. Food reduces the peak concentration in plasma by about 17% but does not slow down the time to reach the peak concentration of the drug.

The ratio attached to plasma proteins is 60 - 70%. The distribution volume 5.4 - 5.8 liters/kg. It is unclear whether the drug through the placenta or excretion in breast milk or not. Fexofenadin does not pass the blood - brain barrier.

About 5% of the metabolized dose. About 0.5 - 1.5% are metabolized in the liver thanks to the cytochrom P450 enzyme system into non -active substances. 3.5% are converted into methyl ester derivatives, mainly thanks to the intestinal bacteria.

FEXOFENADIN's semi -exhaust time is about 14.4 hours, longer in renal failure people. The drug excreted mainly in feces (about 80%), 11 - 12% of the dose is eliminated in the urine in the form of constant.

Before taking Imexofen 180 Imexpharm medicine reduces chronic urticaria (3 blisters x 10 tablets)

How to use

Imexofen 180 medicine for oral.

Dosage

Adults and children over 12 years: 1 tablet/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? However, drowsiness, dizziness, dry mouth have been reported.

Handling: Use conventional measures to remove unprocessed drugs in the gastrointestinal tract. Support support and symptomatic treatment. Hematoparoology reduces the concentration of medication in the blood. There is no specific antidote.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Imexofen 180 drugs often experience unwanted effects (ADR) such as:

In control clinical studies, the unwanted effect rate in the patient group using Fexofenadin is similar to the Placebo group. The unwanted effects of the drug are not affected by the dosage, age, gender and race of the patient.

Common: Sleep, fatigue, headache, insomnia, dizziness, nausea, indigestion, viral infections (colds, flu), dysmenorrhea, upper respiratory infection, itchy throat, cough, fever, otitis media, sinusitis, back pain.

Less: Fear, sleep disorders, nightmares: dry mouth, abdominal pain.

Rare: skin rash, urticaria, itching, angioedema, chest tightness, shortness of breath, redness, anaphylaxis.

Instructions on how to handle ADR:

Notify the physician with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Imexofen 180 contraindications in the following cases:

Hypersensitivity to fexofenadin.

Be cautious when using

must be careful to monitor when using fexofenadin for patients who are at risk of cardiovascular disease or have about Q - T for a long time.

Patients should not use other antihistamines by themselves while using fexofenadin.

Need to be cautious and adjust the appropriate dose when taking drugs for people with impaired renal function.

Safety and effectiveness of drugs in children under 6 years old have not been determined.

Need to stop Fexofenadin at least 24 - 48 hours before conducting injection antigen tests.

Using drugs for women during pregnancy and lactation

Pregnant women: There is no full study on pregnant women, so only use fexofenadin for pregnant women when really necessary.

breastfeeding women: It is not clear whether the drug is excreted through breast milk, but when using terfenadin has detected fexofenadin as the metabolic substance of terfenadin in breast milk. So be cautious when using fexofenadin for breastfeeding women.

The effect of the drug on the ability to drive and operate machinery

The drug is less likely to be drowsy but still need to be cautious when driving and operating machinery.

Medicinal interaction

Use combination of fexofenadin with erythromycin or ketoconazole increasing fexofenadin levels in plasma. However, interactions are not clinical significance.

Group -containing antacids, Magnesi simultaneously with Fexofenadin will reduce the absorption of the drug, so they must use these drugs apart (about 2 hours).

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

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