IMQUAD Cream 5% Glenmark skin treatment (3 packs)

Dosage form 3 -pack box
Specifications Imiquimod

Ingredient

Composition informationContent
Imiquimod5%

Uses

Indications

Imoquad cream 5% is indicated in the following cases:

  • Treatment of adult patients with warts outside the genitals and around the anus. Drugs.

    ImotaD treatment stimulates RNA (Ribonueleie acid, MRNA = Messenger RNA) Messenger of encoding masters for immune adjustment agents (Cytokin) including interferon alpha (INF-α) at ​​the treatment and significantly reduces DNA of HPV and most RNA protein capsit (L1) HPV.

    In vitro Imiquimod has no direct anti-virus effect, however, the drug manifests anti-virus and Vivo resistance effects.

    Imiquimod stimulates the production of different types of immune adjustment agents and seems to be able to enhance anti-virus activity through cell decomposition.

    The drug is a quick and potential promotion to create Inf-α, Interleukin-1 alpha and beta (IL-1A & IL-1β), Interleukin-6 (IL-6), Interleukin-8 (IL-8), U-alpha necrotic factor (TNF-α), factors that stimulate the Granular Group (CM-CSEF) inflammation.

    pharmacokinetic pharmacokinetics

    only a minimum amount of drugs absorbed into the body after use on the spot.

    After giving healthy adults a dose of 5 mg imiquimod is marked with radioactive material in the form of topical cream, in plasma does not find radioactive material (the lower detection limit is 1 ng/ml) and less than 0.9% of the marker is removed in urine and fertilizer.

    • Before taking IMQUAD Cream 5% Glenmark skin treatment (3 packs)

    How to use

    Imoquad cream 5% only use topical skin.

    The treatment doctor should guide patients on how to use the right dose, how to apply cream to the genital warts outside and around the anus.

    Need to wash your hands before and after applying the cream.

    Apply a thin layer of cream to the warts and rub until it is no longer visible.

    The cream is not covered.

    Dosage

    Dosage for adults

    Imiquad cream is packed in small packages containing enough cream for one coverage of warts up to 20 cm2.

    IMiquimod cream needs to be applied before sleeping and saved on the skin for 6 - 10 hours.

    After treatment, the cream is removed by washing with mild soap and water. Apply 3 times a week until all the genital warts are removed and around the anus or for a maximum of 16 weeks. Do not exceed the dose, frequency and treatment time as recommended, as there may be unwanted reactions that occur on the spot (Red Red Red Red Redes, Scratches/Peeling Skin, Edema).

    Need to avoid using an excess cream. If the drug is uncomfortable for the patient or due to the seriousness of side effects, it is necessary to suspend local treatment by imiquimod and then when the reactions decrease in the continued treatment.

    used for children

    Safety and effectiveness of cream for children under 12 years of age has not been established.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

    What to do when overdose? The overdose when using imiquimod on the spot is almost none because only a very small amount of drugs absorbed through the skin. However, the over -overdosing may lead to severe skin reactions.

    In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

    What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

    Side Effects

    When using the 5%Imiquad Cream, you may experience unwanted effects (ADR).

    generally imiquimod when used on the spot is well tolerated.

    The most unwanted effects of the drug are local to medium -sized reactions. Severe reactions need to stop taking drugs accounting for about 1-4% of patients.

    So far there has been no report on serious body reactions when used on the spot Imquimod.

    Effects on the spot and on the skin

  • Unwanted reactions on the spot include Red Red, scratches, peeling and edema often occur at the top of the drug and/or surrounding areas. On -site response is reported by more than 1% of patients when imiquimod on the spot include: itching, burns, pain, vulnerability, skin aches, sensitive, causing pain, rash and pale skin or skin pigmentation on the spot. Scrambles, bottles, ulcers, edema, bleeding, burns, itching, pain, vulnerability and skin fungal infections in remote areas where drugs are applied on some patients using Imiquimod.
  • Systemic reactions such as headache, symptoms like flu, muscle pain, weakness, fever, diarrhea and fungal infection have been reported among patients using Imiquimod on the spot.

    Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    • Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Imoquad Cream 5% contraindicated in the following cases:

  • Patients have been known to have hypersensitivity reactions to imiquimod or any ingredients of the drug.

    • Precautions when using

    only external use.

    Avoid contact with eyes.

    Imiquimod has not been evaluated for use of urinary tract, vaginal, cervical, colon or HPV in the anus.

    There is no clinical experience in local treatment with Imiquimod right after treatment with other skin -based topical medications, so no local treatment with imiquimod until the genital or the anus is healed from any previous medication or surgery.

    Despite the unwanted reactions of Imiquimod on the skin, it is usually light to moderate, but there may also be severe reactions.

    In addition, when used in place Imiquimod can worsen dermatitis. To minimize local reactions during treatment with Imiquimod, 6 - 10 hours after taking each dose of the drug must wash the area applied with mild soap and water.

    If the response is severe on the spot, it is necessary to wash the place with mild soap and water. If it is necessary to stop taking the drug for days until the reaction is reduced to reuse. Wear clothes with easy absorbent cloth (cotton fabric, cotton underwear) to avoid skin reactions.

    Individual immunodeficiency, including HIV -infected people who can respond less with the treatment of genital warts and the anus around HPV compared to those who have immunity and the disease may recur more after treatment. In addition, the frequency of biopsy to confirm the diagnosis of warts caused by HPV may require more for immunodeficiency individuals, because in these individuals cancer can occur more than producing scales or similar to HPV warts.

    If there are new warts developed by HPV while or after treatment with drugs, do not use imiquimod to treat local anymore and also notify the patient.

    It is unknown the impact of imiquimod treatment on the movement of HPV and because the cream may damage condoms or diaphragm, which loses the blockage effect, it should be noted that patients do not believe in these tools to prevent sexually transmitted diseases or get pregnant during local treatment with imiquimod.

    A warning to patients should avoid sex (genitals, anus, mouth) while imiquimod is still on the skin.

    It is also necessary to notify the patient with skin color changes that occur on the top of the drug and sometimes these changes exist for a long time.

    The ability to drive and operate machinery

    No report.

    Pregnancy

    Pregnancy type b.

    There is no evidence of teratogenic properties when rats and rabbits drink imiquimod.

    Giving the mother's mouse to the poisonous doses of imiquimod equivalent to 28 times the dose for humans (calculated by mg/m2) has shown the weight reduced, the bone chemistry is slowed down.

    There is no unwanted effect that is proven on the mouse's baby during pregnancy treated with an Imiquimod dose 8 times the usual doses for humans.

    There are no appropriate and control studies using Imiquimod for pregnant women.

    Therefore, Imiquimod is not for pregnant women.

    Breastfeeding period

    Do not know if Ding Imiquimod outside the medicine goes into breast milk, so do not use Imiquimod for breastfeeding women.

    Drug interaction

    No report.

    Storage

    Store drugs below 30 ° C, avoid freezing.

    To be out of reach of children.

    Expiry date: 24 months from the date of manufacture. Do not use overdue drugs stated on the packaging.

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