India 850mg indeper drugs for diabetes treatment (4 blisters x 14 tablets)

Dosage form Box of 4 blisters x 14 tablets
Specifications Metformin

Ingredient

Composition information	Content
Metformin	850mg

Uses

Indications

Treatment of type 2 diabetes (mellitus) for adults, especially obese patients, who have diet and exercise patients but do not control blood glucose levels. Metformin can be used separately or combined with other oral diabetes treatments, or in combination with insulin.

Reducing diabetes complications found in obese patients with type 2 diabetes treatment with metformin is the first way to choose after dieting without results. Metformin HCl tablets are indicated for patients 10 years of age or older.

Pharmacokological

metformin has anti -glucose anti -glucose effects, in order to improve glucose tolerance for patients with diabetes that do not depend on insulin, reducing the basic glucose level in plasma and after eating. Metformin reduces the production of glucose in the liver, reduces the absorption of glucose in the intestine, and improves the sensitivity of insulin (increases the consumption and use of peripheral glucose). Unlike the sulfonylurea, metformin does not cause hypoglycemia in patients with diabetes and those who do not have diabetes. Metformin does not cause increased blood insulin.

pharmacokinetic

absorption

metformin is absorbed in the gastrointestinal tract after taken; Birth of the pill is approximately 50%.

Distribution

The circulatory drug in the form of non -binding and the amount of cohesion with plasma proteins can be considered negligible.

Metabolism

Metformin is not metabolized.

Elimination

Half of the lifetime elimination of plasma metformin in approximately 2 hours is the main period of clearance, reaching about 90% of the absorbed amount of the drug. The remaining 10%, distributed in tissue, is very slow with the last half -life elimination from 9 to 12 hours. Metformin is exported very quickly through the urine, the renal clearance of healthy people reaches an average of 440 ml/minute (4-5 times the creatinine clearance), due to platelet scroll filter and then the issue in the kidney. In addition, excretion life increases in people with renal failure leading to the risk of accumulation of drugs.

Before taking India 850mg indeper drugs for diabetes treatment (4 blisters x 14 tablets)

How to use

Take the Indones 850 with or after meals. Take medicine with water.

Dosage

separate treatment and combined with other oral diabetes treatment drugs:

The maximum daily dose of Metformin HCI tablets is 2550 mg for adults and 2000 mg for children (from 10 - 16 years old) to drink with or after meals. The maximum daily dose of Metformin HCI must be divided into meals. The dose may increase, every week increases 500 mg or every 2 weeks increased by 850 mg, up to a maximum of 2000 mg/day, divided equally during the day.

Adults: Metfomin combination with insulin can be used to achieve better blood glucose control. The initial dose of metformin treatment is: 1 tablet x 2-3 times/day, while the dose with insulin is changed according to the degree of blood glucose. It is necessary to assess the kidney function. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Therefore, blood separator can be used to overdose.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

Common, ADR> 1/100

Digestive: diarrhea, nausea, abdominal pain, flatulence, anorexia.

Not yet reported.

Not determined frequency

metabolism and nutrition: Lactic acid infection.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

People who are sensitive to metformin or any ingredients of the drug. µmol/l in women. Alcoholism.

Pregnant women, nursing mothers and children under 10 years old.

Precautions when using

Warning

Lactic acid infection may occur rare but serious, this complication may be due to metformin accumulation during treatment. Patients with congestive heart failure are being treated, especially those with unstable or acute congestive or acute congestive heart failure who are at high risk of lactic acid infection. The risk of lactic acid infection increases according to the degree of renal function and patient conditions. Metformin should be stopped immediately if there is any sign of hypoxemia, dehydration or infection. Because liver failure can significantly reduce the ability to clear lactate, so avoid using this medication for patients who are clinically tested or tested for liver disease. Patients should pay attention not to drink much alcohol while using Metformin because alcohol has an effect on the metabolism of lactate of metformin. Metformin must be temporarily stopped before conducting blood vessels or any surgery.

Caution

Hypoglycemia: Hypoglyc does not occur with patients treated with Metformin alone in normal cases but may occur when the amount of calories provided is missing, when practicing stress without adequate calories, when combined with other blood glucose drugs (such as sulfonylurea) or alcohol or drinking.

Elderly patients, physical weakness, malnutrition, people with adrenal or thyroid impairment or alcoholic poisoning, often sensitive to hypoglycemia. The phenomenon of hypoglycemia can be difficult to identify in the elderly and users of beta-adrenergic blockers.

Monitoring of kidney function: Risks due to metformin accumulation and lactic acid infection increase depending on the level of patient's renal function. Therefore, it is necessary to monitor kidney function regularly and stop taking the drug immediately if signs of kidney damage occur.

loss of blood glucose control: During stable treatment with any treatment of diabetes that has fever, injury, bacterial, surgery, may occur in blood glucose loss. In such a case, Metformin must be stopped and temporarily treated with insulin. Can be re -treated with metformin after the acute symptoms have terminated.

Used for the elderly: Metformin is given a problem through the kidneys so the unwanted effects of the drug for people with kidney failure are more serious than ordinary people but age is associated with reduced kidney function, so be cautious when using Metformin for the elderly.

The ability to drive and operate machinery

Not yet reported.

Pregnancy

Contraindicated for pregnant women.

Breastfeeding period

Drug interaction

Must be cautious when taking Metformin with the following drugs:

Furosemide: Furosemide increases the concentration of plasma metformin and in the blood but does not significantly change the metformin clearance of the kidney. When 2 drugs are used in combination, the concentration of Furosemide decreases compared to when used separately, half -life eliminates reduced, Furosemide clearance in the kidney changes significantly.

Nifedipine: When combined with nifedipine, increased the level of metformin in plasma and increased the amount of drugs exported through the urine. Nifedipine increases the absorption of Metformin. Metformin has little effect on nifedipine.

Cation drugs (such as digoxin, morphine, quinidine, ranitidine ...) are given through the renal tubules, theoretical interaction with Metformin due to the competition in switching through the renal tubular system. Such drug interaction between Metformin and Cimetidine oral Cimetidine has been observed.

Some medications that cause hypoglycemic glucose can lead to loss of blood control, including: Thiazide and other diuretics, corticosteroids, phenothiazine, thyroid drugs, oral contraceptives, estrogen, phenytoin, nicotine acids, sympathetic drugs, Calcium and Isoniazide channel blockers. When taking the above drugs for patients being treated with Metformin, it is necessary to closely monitor the loss of blood glucose. When stopping taking these drugs for patients who are being treated with Metformin, they must also be closely monitored on the phenomenon of hypoglycemia.

Storage

Store in a cool, dry and dark place, at temperatures below 30 ° C.

To stay out of reach of children.

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