IPEC-Plus Aristopharma treatments for iron deficiency, folic acid and zinc (3 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 3 blisters x 10 tablets
Ingredient Fe (III), folic acid, zinc
Indication Iron anemia

Ingredient

Composition information	Content
Fe (III)	47mg
Folic acid	0.5mg
Zinc	22.5mg

Uses

indications

IPEC - Plus drugs are indicated in the following cases:

Prevention and treatment of iron deficiency, folic acid and zinc.

Pharmacological

iron complex (III) Hydroxide polymaltose is a water soluble, a large magnetic complex of iron polynuclear (III) hydroxide and a part of hydrolysis dextrin (polymaltose). Rapidly absorbed with high ratio of iron used and the drug has the effect of increasing the synthesis of hemoglobin.

Folic acid helps children's integrity.

Zinc keeps the enzyme operating and helps to metabolize protein.

Dynamic pharmacokinetics

Hydroxide polymaltose complex

The iron absorption from iron complex (III) polymaltose is the same as the physiological form. When the iron complex (III) polymaltose is exposed to the site of iron on the surface of the mucous membrane cell, at this time there is a physiological exchange, iron complex (III) polymaltose releases a desired amount of iron, thanks to the transport activity in mucous membrane cells by protein carrier and this release also for ferritin or transferrin.

Protein carrier is responsible for transporting iron from iron (III) polymaltose in mucous membranes, intestines and mobile iron. The bioavailability of iron from iron (III) polymaltose is determined by the release of iron protein (protein) in mucous membranes, intestines and mobile iron. Iron is released from protein and iron carrier in the mucous membrane cell in the form of ferritin or protein carrier to coordinate with transferrin.

Organic salt is taken into one of the two forms, Fe ++ or Fe +++ iron precipitate (III) hydroxide in physiological pH and the absorption is supported by stomach acid to maintain iron (III) in soluble form. Usually absorbing about 10% of 10 - 20 mg of iron to eat a day in the average diet. Citrate and Ascorbate increased iron absorption by the soluble complex form that easily passed through the gastrointestinal epithelial cell layer. Other compounds such as tannin are in tea, plant forms and phosphates complexes significantly inhibit iron absorption.

The first iron is equal to the intestinal epithelium and then combined with transferrin is a serum glycoprotein transporting iron to the tissue of the body. Each transferrin molecule can carry two iron atoms. Usually about 20 - 45% of the iron mounting location is connected. Special receptors in plasma are recognized as transferrin, control the entry of this complex into the cell and release iron from protein in the cytoplasm.The basic iron of classical iron production in the form of iron ions (III) increases gastric irritation change. The absorption of iron from the form of iron salt will usually be passive and not controlled because it is not only constantly in the mucous membrane cell of the gastrointestinal tract but also in the blood circulation in the blood in the circulatory system, increasing the change of overloaded iron, but exceeding the safety amount or as the preparation exceeds the time period.

The overloaded iron can be a cause not only toxic to the body in the path of developing iron pigmentation (except iron deposits in tissues such as liver, muscle, kidney and brain) but also increases the formation of free radicals. Therefore, there is a major difference in the pharmacological and pharmacokinetics of iron (III) polymaltose unlike iron salt (II) and iron (III). With polymaltose iron complex is more secure because it does not produce free radicals as well as other consequences of the above forms when it exceeds the iron load.

Iron complex (III) polymaltose is also better tolerated because it is not ionized, and does not cause stomach irritation. Moreover, due to the separate way of indirect transportation of iron (III) polymaltose, it has no pharmacological interaction with other drugs, which can occur with regular iron salts as mentioned above.

Folic acid

After drinking, folic acid is absorbed quickly from the digestive tract. Vitamins are absorbed mainly in the small intestine. After absorbing 1 mg or less, most of the acid is reduced and methylation in the liver into acid N - 5 - methyllahydrofolic, is the main form of folate in the body. Folic acid at higher doses can escape the metabolism in the liver and appear in the blood mainly in the form of folic acid.

zinc sulphate

20% - 30% of the intake of zinc is absorbed through the gastrointestinal tract. The excretory road is mainly through the intestine. Only a very small amount of urine.

Before taking IPEC-Plus Aristopharma treatments for iron deficiency, folic acid and zinc (3 blisters x 10 tablets)

How to use

Take oral use.

Dosage

One tablet daily. May need two tablets a day in severe cases or as directed by the physician.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

After taking a large amount of medicine, cases of iron overdose have been recorded, especially in children under 2 years of age, symptoms include irritation and stomach activity, nausea, vomiting and shock.

Treatment

Proceed with 1%sodium bicarbonate solution. Using chelate complex substances is very effective, especially when using Deferoxamine, especially when the concentration of iron in the blood> 5 µg/ml. Shocking, dehydration and acid - base abnormalities are treated with classical methods.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using IPEC - Plus you may experience some unwanted effects (ADR).

IPEC - Plus well tolerated. Sometimes stomach irritation such as a feeling of bloating, epigastric pain, nausea, constipation or diarrhea.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

IPEC - Plus drug contraindicated in the following cases:

Sensitive to any ingredients of the drug.

Be cautious when using

as well as other iron precursors, the color of the drug can appear without clinical significance.

The ability to drive and operate machinery

no.

During pregnancy and lactation

necessary for pregnant and lactating women.

Drug interaction

no interaction between polymaltose and food or between polymaltose iron and other drugs because it is a natural ionic form.

Storage

Store in a cool dry place, not more than 30 ° C, avoiding light and moisture. To be out of reach of children.

Other drugs

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