Irbesartan Stella 300mg treatment for hypertension and kidney disease due to diabetes (2 blisters x 14 tablets)

Dosage form Box of 2 blisters x 14 tablets
Specifications Irbesartan

Ingredient

Composition information	Content
Irbesartan	300mg

Uses

Indications

Irbesartan 300 drug is indicated in the following cases:

Hypertension: Irbesartan is used alone or in combination with other hypertension treatment groups in the treatment of hypertension. pressure.

Mechanism of action: Prevent all the effects of Angiotensin II through the AT1 receptor intermediaries, regardless of the origin or synthetic path of Angiotensin II. Selective antagonistic effect on AT1 receptor, leading to increased plasma renin and decreased serum aldosteron levels. The concentration of potassium in serum is not significantly affected when using solitary irbesartan in the recommended dose. Irbesartan does not inhibit the enzyme (Kininase II), an enzyme that produces angiotensin II and bridge bradykinin into inactive metabolites. Irbesartan does not need to be converted into metabolites to have this effect.

pharmacokinetics

Irbesartan is quickly absorbed by gastrointestinal tract with oral bioavailability 60 - 80%. The peak concentration of plasma of Irbesartan is reached from 1.5 to 2 hours after drinking. About 96% Irbesartan binds to plasma proteins. The drug is metabolized through the liver, mainly by Cytochrom P450 ISOENZYM CYP2C9 into non -active metabolites. The drug is eliminated in a constant form and metabolic in bile and urine. The last waste sale time is about 11 - 15 hours.

Before taking Irbesartan Stella 300mg treatment for hypertension and kidney disease due to diabetes (2 blisters x 14 tablets)

How to use

The drug is used by oral and regardless of the meal.

Dosage

Hypertension

Adults: Irbesartan's usual starting dose in adults is 150 mg x 1 time/day for patients without impaired internal volume. If the starting dose is still in the beginning, the blood pressure is still not able to lower the desired, can increase the dose up to 300 mg x 1 time/day or may use additional diuretics. Irbesartan can also be used in combination with other hypertension medications.

Starting for treatment with low dose of 75 mg daily for people over 75 years old, patients with impaired intravascular volume and patients are hemolysis.

Kidney disease due to diabetes

In the treatment of kidney disease in patients with type 2 diabetes with hypertension, it is advisable to start with the dose of Irbesartan 75 mg 1 time/day, up to 300 mg 1 time/day as a maintenance dose.

Patients with kidney failure, liver failure

No dose adjustments in patients with renal failure, liver failure.

Children

Irbesartan's usual starting dose in children 6 -12 years old or 13-16 -year -old teenagers with hypertension are 75 mg or 150 mg x once a day. If the response of blood pressure is not enough for the starting dose, the dose may be increased to 150 mg or 300 mg x 1 time/day for children or adolescents; Do not use higher doses.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Slow heart rate can also occur. There is no specific therapy in the treatment of Irbesartan overdose. Patients should be monitored and symptomatic treatment and supportive treatment. Irbesartan cannot be excluded by hemolysis.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Irbesartan 300, you may experience unwanted effects (ADR).

Not determined frequency

Neurological: dizzy, headache.

allergies: rash, urticaria, itching, angioedema.

Liver: increase enzyme.

muscle - bone - joints: muscle pain, joint pain, back pain.

kidney: impaired renal function. digestive: digestive disorders. Respiratory: Respiratory disorders.

Other: fatigue, neutropenia, hypotension depending on the dose, hyperkalemia.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Irbesartan 300 drug contraindicated in the following cases:

Hypersensitivity to Irbesartan or any ingredients of the drug.

Pregnant women.

Women who are breastfeeding.

Precautions when used

Starting treatment with hypertension can cause symptomic hypotension in patients with intravascular volume decline or sodium reduction, for example, patients use strong diuretic therapy or fertilizer. This decrease in the volume of epidemic should be adjusted before taking Irbesartan or the starting dose is lower.

In general, in patients with blood vessel tone and renal function depend mainly on the activity of the Renin-Anotensin-Aldosteron system (such as severe congestive heart failure or kidney disease, including kidney stenosis), treatment with transferred inhibitors or Angiotensin II receptor antagonists are drugs that can affect this system, which can cause blood pressure, hypertension, hyperurize, hyperur Acute renal failure. Like all other hypotension, excessive hypotension in patients with ischemic heart disease can lead to myocardial infarction or stroke.

Irbesartan contains lactose excipients. This drug should not be used for patients with rare genetic problems galactose intolerance, total lactase enzyme deficiency or glucose - galactose.

The ability to drive and operate machinery

When driving and operating machinery, it should be noted that dizziness or fatigue may occur during treatment

Pregnancy

should stop taking Irbesartan as soon as possible when being diagnosed with pregnancy.

Breastfeeding period

Due to the risk of side effects in breastfeeding, should stop breastfeeding or stopping the drug.

Medicinal interaction

Diuretics and other hypertension drugs: may increase the hypotension effect of Irbesartan.

Potassium supplements and potassium -saving diuretic supplements: can lead to increased serum potassium levels.

Lithi: Need to carefully monitor serum lithium concentration if this combination is necessary.

Non -steroid anti -inflammatory drugs: reduce hypertension.

There is no significant pharmacokinetic interaction (or pharmaceutical) in studies on interactive with hydrochlorothiazid, digoxin, warfarin and nifedipine. Based on in vitro data, there is no possibility of interacting with drugs that their metabolism depends on Cytochrom P450 ISOENZYM 1A1, 1A2, 2A6, 2B6, 2D6, 2E1 or 3A4.

Storage

In closed packaging, dry place. The temperature does not exceed 30 ° C.

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