Itamelagin 500mg medicine for vaginal candidiasis (10 tablets)

Dosage form Box of 2 blisters x 5 tablets
Specifications Metronidazole, miconazole, lactobacillus acidophilus

Ingredient

Composition information	Content
Metronidazole	500mg
Miconazole	100mg
Lactobacillus acidophilus	50mg

Uses

Indications

iamelagin is a broad -spectrum antifungal combination preparation, which can inhibit the activity of both trichomonas spp.

Iamelagin is indicated in the treatment of vaginal candidiasis and vaginal superinfection caused by gram (-) and gram (+) bacteria. Lactobacillus spp in preparations that promote the vaginal physiological environment back to normal.

Pharmacokology

metronidazol

Metronidazol is a derivative 5 - nitro - imidazole, has a broad spectrum on virgin animals such as amoeba, giardia and in anaerobic bacteria.

Metronidazol is a very strong drug in the treatment of primeval animal infections such as Entamoeba Histolytica, Giardia Lamblia and Trichomonas Vaginalis. Metronidazole has bactericidal effects on bacteroides, fusobacterium and other mandatory anaerobic bacteria, but does not have the effect on narrow bacteria. When infected with both anaerobic and anaerobic bacteria, Metronidazol must be combined with other antibacterial drugs.

Trichomonas vaginalis infection can be treated with Metronidazol oral oral oral use. Both women and men must be treated, because men can carry pathogens without symptoms. In many cases of coordination treatment of vaginal drug and tablets.

When bacterial/vaginal inflammation is caused by bacterial/vagina, Metronidazol will cause the vaginal bacteria to return to normal in the majority of patients who use Metronidazol drugs that do not impact on the normal vaginal bacteria. When gynecological infections such as endocarditis from bacterial and abscesses need to combine metronidazol with a beta lactam antibiotic, such as a new generation cephalosporin.

Metronidazol strains have been shown to contain low ferredoxin, which is a catalytic protein when chemical metronidazol in those strains. Ferredoxine decreases but not completely lost, probably explain why infections with those strains respond to higher Metronidazol doses and longer.

miconazole nitrate

miconazol is a synthetic Inidazol drug that has anti -fungal effects on types such as Aspergillus, Blastomyces, Candida, Cladosporium, Coccidioides, Epidermophyton, Histoplasma, Madhurella, Pityrosporon, Microscide, Paracoccidioides, Phialophora, PhialoPhora, Pseuderian and Pseu Trichophyton.

Miconazole also works with Gram -positive bacteria. Miconazole inhibits the synthesis of ergosterol in the fungal cell membrane that inhibits the growth of the fungal bacteria cells.

pharmacokinetic

metronidazole

Put a single dose of 5g gel into the vagina (equal to 37.5 mg of metronidazol), the average serum metronidazole concentration is 237 nanogam/ml (from 152 to 368 nanogam/ml). This concentration is about 2% of Metronidazol concentration Maximum average serum after drinking once 500 mg of metronidazol (the average CMAX is 12,785 nanogam/ml). These peak concentrations reached 6 - 12 hours after using the gel in the vagina and 1-3 hours after taking Metronidazol.

The degree of exposure to the drug (an area below the AUC curved) when used single in the vagina 5 g of Metronidazol Gel (equivalent to 37.5 mg) is about 4% AUC when drinking once 500 mg of metronidazol (4977 nanogam - hour/ml and 125 000 nanograms - hours/ml). Compare AUC on the basis of Mg with Mg of 2 ways to prove that the absorption of Metronidazol when using the vagina is only half when taken if used equally.

miconazole nitrate

When used outside, miconazole absorbs through the skin's charism and absorbs into the blood below 1%. But if placed in the vagina, it will absorb the blood of less than 1.3%.

When using intravenous lines, transmitted at a dose higher than 9 mg/kg body weight, plasma concentration reaches higher than 1 microgram/1 ml. There is a high percentage of miconazole sensitive mushrooms inhibited by blood -micrograms of 2 micrograms/noodles or less. The metabolism of miconazol by intravenous line through 3 stages: half -life in the first phase of about 0.4 hours, the period between 2.5 hours and half -life eliminating the radio to about 24 hours. In the blood, about 90% miconazole is attached to plasma proteins and is converted in the liver into substances that no longer work. 10-20% excreted in urine in the form of metabolized.

Before taking Itamelagin 500mg medicine for vaginal candidiasis (10 tablets)

How to use

Itamelagin bullets may be soft during storage. Therefore, the drug should be stored in the refrigerator cooler so that the pill can be more mucus, easy to place.

Put pills into the vagina, best in lying position.

Dosage

Put 1 capsule daily in the vagina, preferably in the evening, within 2 weeks.

Do not take the pills. The drug is only used when prescribed by a doctor.

What to do when overdose?
What to do when forgetting a dose? However, if it is almost time for the next dose, it is advisable to skip the forgotten dose. Take care not to use double the prescribed dose.

Side Effects

When using otamelagin often has unwanted effects (ADR) such as hot or on -site irritation right after placing the vagina appear with a small number of patients.

Inform the doctor to know the side effects encountered when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Iamamelagin contraindicated drug in the following cases:

There is a history of hypersensitivity to Metronidazole and Miconazole Nitrate or any ingredients of the drug.

Be cautious when using

There has been reports on Disulfiram reaction with alcohol and Metronidazole oral. Therefore, patients need to be careful not to drink alcohol while being treated with Metronidazole.

Treatment time should be limited because of the dangers of the selection of resistance strains and the risk of superinfection caused by these bacteria.

Do not stop treatment during menstruation.

Do not douche the vagina unless there is a doctor's instructions, because vaginal douching can disrupt bacterial balance.

Should dry out the vagina completely after bathing, or swimming. Should change wet clothes as soon as possible. Because dry conditions help you limit the growth of yeast.

Used for pregnant and lactating women

Not for pregnant women in the first 3 months.

very cautious when using the drug for the remaining stages of pregnancy. ITAMELAGIN should only be used when it is really necessary.

The effect of the drug on driving and operating machinery

The drug does not cause any significant side effects on the ability to drive and operate machinery.

Drug interaction

has reported that Metronidazole has the ability to increase Warfarin's anticoagulant and other anticoagulants in the Coumarin group, leading to prolonged blood clotting time.

In patients stabilizing with relative high doses of lithium, the short -term Metronidazole treatment is related to serum lithium and in some cases showing signs of lithium poisoning.

Miconazole may increase the effects of oral anticoagulants (Coumarin and Warfarin).

Miconazole may increase the plasma concentration of phenytoin to the point that can be harmful to the metabolism of phenytoin in the liver.

Avoid using topical medications on the same area during the treatment period with iTamelagin because it does not exclude the risk of interaction with each other.

Storage

Store at room temperature, below 30 degrees C. Avoid light.

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