Ivermectin 3mg Pharmaceutical 3-2 tablets support the treatment of worm infections (1 blister x 4 tablets)

Dosage form Box of 4 blisters x 1 tablet
Specifications Ivermectin

Ingredient

Composition information	Content
Ivermectin	3mg

Uses

indications

Ivermectin is indicated to treat worms only onchocerca, although the drug has a good effect in the treatment of worms including eelworms in the intestinal worm due to Strongyloides stercoralis.

The role of Ivermectin in worm disease in the lymphatic system has not been carefully studied.

Pharmacology

Ivermectin is the semi -synthetic substance of one of Avermectin, a group of large lacton structons, isolated from the fermentation of Streptomyces Avermitilis. Ivermectin has a broad spectrum on roundworms and secretions of cattle, thus being used in veterinary.

The first drug was used for humans in 1981. Ivermectin is effective on a variety of round worms such as eelworms, hair worms, needle worms, roundworms, hookworms and Wuchereria bancrofti. However, the drug does not work on liver fluke and tapeworms.

Currently, Ivermectin is a chosen drug to treat worms only onchocerca Volvulus and is a worm larvae that is only very strong, but has little effect on mature parasites. After drinking for 2-3 days, the worm larvae only go away quickly; The larvae in the cornea and eye room are slower.

The effect of the drug may last up to 12 months. One month after use, the larvae at the uterus only mature unable to escape, and then degenerated and eliminated. The effect of prolonged larvae is very helpful in preventing the spread of the disease.

already know quite well the mechanism of action of Ivermectin on worms only onchocerca. The drug causes direct toxic effects, immobile and eliminating larvae through lymphatic lymphatic. Ivermectin stimulates neurotransmitter secretion is Gama-Amino Butyric Acid (GABA).

In sensitive worms, the drug affects by enhancing the release of gaba after the synap of the neuromuscular joint causing the worm to be paralyzed.

Ivermectin does not easily join the central nervous system of mammals. Therefore, it does not affect the nerve conduction dependent of these species.

pharmacokinetics

unknown the bioavailability of the drug after taken.

In general, there is no difference in the peak concentration in the plasma between the tablet form and the capsule form (46 compared to 50 micrograms/liter). However, when using ivectin in a water solution with alcohol, the peak concentration doubled and the relative bioavailability of the tablet is only 60% of the bioavailability of the solution.

Time reaches a peak concentration in plasma for about 4 hours and is not different between the form of preparation. Ivermectin has an apparent distribution of about 48 liters and very low clearance (about 1.2 liters/hour). Half life eliminates after taking the solution for about 28 hours. About 93% of the drug associated with plasma protein.

Chuyển hóa của thuốc chưa được nghiên cứu kỹ, tuy nhiên đã thấy thuốc bị thủy phân và bị khử methyl ở gan. Ivermectin is excreted through bile and eliminates almost only through stool. Less than 1% of the dose is discharged through urine.

Before taking Ivermectin 3mg Pharmaceutical 3-2 tablets support the treatment of worm infections (1 blister x 4 tablets)

How to use

Ivermectin drink with water in the early morning when not eaten or maybe another time. However, avoid eating within 2 hours before and after taking the drug.

Dosage

Children under 5 years old

Not yet determined the safety of drugs for children under 5 years old.

Adults and children over 5 years old

Use a single dose of 0.15 mg/kg. Higher dose will increase the harmful reaction, without increasing treatment effect.

It is necessary to re -treat the above dose every year to make sure to control the worm larvae only onchocerca.

If the patient is seriously infected with the larvae, it may be more frequent treatment, such as after every 6 months to use the medication once.

Body weight 15 - 25kg: single dose: 3 mg.

Body 26 - 44 kg: single dose: 6 mg.

Body 45 - 64 kg: single dose: 9 mg.

Body weight 65 - 84 kg: single dose: 12mg.

Body weight ≥ 85kg: single dose: 0.15 mg/kg.

What do

do when overdose?

Other unwanted effects include seizures, air conditioning, shortness of breath, abdominal pain, abdominal pain and urticaria.

When infected, infusion and electrolytes, respiratory aids (oxygen and artificial respiration if needed), use hypertension if hypotension. Causes vomiting or gastric wash as soon as possible.

After that, use bleach and other anti -toxic measures if needed to prevent the absorption of more drugs into the body.

What to do when you forget 1 dose?

If you forget a dose, use as soon as possible.

However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

Ivermectin is a safe drug, very suitable for broad treatment programs. Most of the unwanted effects of the drug are due to immune reactions for dead larvae.

Therefore, the severity of this effect is related to the density of larvae in the skin. Unwanted effects have been notified including fever, itching, dizziness, edema, skin rash, sensitive pain in lymph nodes, sweating, shivering, muscle pain, swelling of joints, swelling of the face (Mazzotti reaction). Hypoglycemic hypotension has been released with sweating, tachycardia and confusion.

Unwanted effects often occur in the first 3 days after treatment and depending on the dose. The ratio of unwanted effects has been very different informed.

In a report, there are 50,929 patients using Ivermectin, unwanted effects about 9%. In areas with high circulation, the ratio of unwanted effects can be much higher.

Here are ADR in the treatment of worms only onchocerca dose 0.1 - 0.2 mg/kg:

Common, ADR> 1/100

Osteoarthritis: joint pain/epidemic inflammation (9.3%). (22.7%).

Central nervous system: headache (0.2%).

Notify the physician the unwanted effects when using the drug.

Warnings

Contraindicated

Ivermectin 3 mg contraindicated for the following cases:

Patients who are sensitive to any component of the drug.

Caution when using

does not have much experience using drugs for children under 5 years old, so it is not for this age.

Due to gaba increased drugs, there is a notion that the drug has the effect on the central nervous system in humans, the barrier of the brain is damaged (such as in meningitis, trypanosoma disease).

When treated with Ivermectin for people with worm -caused dermatitis onchocerca, the reaction can be increased, more harmful reactions may occur, especially edema and make the condition worse.

To be out of reach of children.

The ability to drive and operate machinery

There is no data showing that the drug has an influence on the ability to drive and operate machinery. However, the unwanted effect of the drug is headache, dizziness, hypotension that may occur. Therefore, it is necessary to be cautious when driving and operating dangerous machines.

During pregnancy and lactation

pregnancy

Materials on people are limited. A study conducted a wide area of over 14,000 patients taking medication once a year, in 3 years, 203 babies were born from mothers who used drugs during pregnancy. The results showed that the defects in babies born from mothers who use drugs are not different from the children of mothers who do not take medicine.

Because worm larvae are only onchocercca, it is easy to cause blindness, there has been no report on the possibility of teratogenicity, although the drug has been used on a very wide range, Ivermectin can be used after 3 months of pregnancy.

Breastfeeding period

Ivermectin secretes breast milk with low concentrations (less than 2% of the drug used). Safety for infants has not been determined, so only this medication is for the mother when it is more beneficial to the mother.

Drug interaction

There has been no notice of harmful drug interactions, but theoretically, the drug can increase the effects of GABA receptors stimulating drugs (such as benzodiazepine and sodium valproat).

Storage

Store in a dry place, avoid light, temperature not exceeding 30 ° C.

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