Japrolox Tablets 60mg Daiichi Treatment of chronic rheumatoid arthritis, osteoarthritis (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Loxoprofen

Ingredient

Composition information	Content
Loxoprofen	60mg

Uses

Indications

Japrolox drug is indicated in the following cases:

To reduce inflammation and pain in the following disorders and symptoms: rheumatoid arthritis, osteoarthritis - joints, lower back pain, shoulder arthritis, neck - arm syndrome, toothache. level). This is a drug that after being absorbed from the intestine, biological conversion into an active metabolic substance to promote the effect.

Analgesic effect

Loxoprofen Sodium Hydrate has been shown that the ED50 of the dose of 0.13 mg/kg in the Randoll-Selitto test (the method of pressure on the legs of the rats is inflamed: oral use), analgesic effect is 10 to 20 times higher than the effects of other comparative drugs such as Ketoprofen, Naproxen and Indomethacin.

According to the assessment in the trial of inflammatory wounds in the mouse (oral use), the sodium hydrated loxoprofen shows the ID50 of the dose of 0.76 mg/kg and is shown to act as Naproxen and 3 to 5 times the effect compared to Ketoprofen and Indomethacin.

In chronic arthritis pain test (mouse, P.O.) Loxoprofen sodium hydrate has a special analgesic effect (ED50 at a dose of 0.53 mg/kg), 4 to 6 times higher than indomethacin, ketoprofen and naproxen.

Pain effect of the drug is in the periphery.

Anti -inflammatory effect

Loxoprofen Sodium Hydrate creates an essential anti -inflammatory effect that can be compared to the effects of ketoprofen and naproxen in acute and chronic inflammation as edematous caused by Carrageenin (on mice) and complementary arthritis (on mice).

Effect of reducing fever

Loxoprofen Sodium Hydrate has been shown to show the essential antipyretic effect that can be compared to the effect of ketoprofen and naproxen and about 3 times the effect compared to indomethacin in the fever caused by yeast (on mice).

Mechanism of action

Prostaglandin biosynthesis inhibit the acting mechanism of this drug, the location of the oxidation is. When taken orally, Loxoprofen Sodium Hydrate is absorbed from the digestive tube in the form of a constant compound with the least stomach irritation. The drug is then quickly transformed into a transformed isomer transformer (SRS combination) with the potential inhibiting the potential biosynthesis of prostaglandin to create pharmacological effects of the drug.

pharmacokinetic pharmacokinetics

Absorption and metabolism

Give sixteen healthy adult volunteers oral medication to see that Japrolox is quickly absorbed after taking a single dose of 60 mg, and Loxoprofen (constant drug) and its trans-oh isomer (active metabolites) seen in the blood. The time to achieve a plasma peak concentration is about 30 minutes for Loxoprofen and about 50 minutes for trans-oh isomer, with half-life of semi-waste for approximately 1 hour and 15 minutes for both substances.

Drug metabolic enzymes

Loxoprofen Sodium Hydrate does not affect the metabolism of other drugs, but acts as a substrate for the cytochrome p450 (CYP1A1/2, 2A6, 2B6, 2C8, 2C19, 2C19, 2D6, 2E1, and 3A4), even at a high concentration of 10 times more than a plasma peak concentration (200 μm) in one research on one research on a research research research Chemistry performed in a laboratory with human liver microsome.

The ratio of plasma protein bonds as determined in humans (over 5 individuals at 1 hour after taking Japrolox tablets dose 60 mg) respectively 97.0% and 92.8% for loxoprofen and trans-oh isomers.

japrolox is quickly excreted in the urine, mainly in the form of assembled with glucuronate of looxoprofen and trans-oh isomer.

Excretion in urine after taking Japrolox tablets single 60 mg.

Before taking Japrolox Tablets 60mg Daiichi Treatment of chronic rheumatoid arthritis, osteoarthritis (2 blisters x 10 tablets)

How to use

Oral drugs.

Dosage

Dosage and how to reduce inflammation and pain

The usual dose for adults is 60 mg of sodium Loxoprofen (anhydrous form) orally 3 times a day. Dosage when needed, dose from 60-120 mg each time orally. The patient's age and symptoms can be adjusted. Should avoid taking this medicine during hunger.

Dosage and how to reduce fever and analgesic

The usual dose for adults is 60 mg of Loxoprofen sodium (anhydrous) dose when orally needed. The patient's age and symptoms can be adjusted. As a rule, this medication with a maximum daily dose is recommended by 2 times a day, up to 180 mg/day. Should avoid taking this medicine during hunger.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? There is no specific antidote for sodium hydrate Loxoprofen, which can be handled overdose by common measures such as reducing absorption (e.g. gastric lavage and activated carbon) and increased excretion. In case of an overdose or an overdose, the patient should be monitored and maintained the appropriate water and electric compensation measures. Should use symptomatic treatment and supportive treatment.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Japrolox, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive (stomach discomfort, abdominal pain, nausea and/or vomiting, anorexia).

Phu, ban, urticaria and drowsiness.

Unknown frequency

Shocking and anaphylaxis symptoms (reducing blood pressure, urticaria, laryngeal edema, shortness of breath).

Hemolytic anemia, leukopenia, and platelets.

SKIN MULTURE SOLUTION (Stevens-Johnson Syndrome) and epidermal poisoning (Lyell syndrome).

Acute renal failure, kidney syndrome and interstitial nephritis.

Heartbreaking heart failure.

Serious digestive ulcers or stomach bleeding in the small intestine and/or colon, for example, vomiting of blood, black blood defecation and bloody stools, and shock.

Perforation of the stomach.

Liver dysfunction (jaundice, increase AST (GOT), ALT (GPT) and γ-AGP in serum) or sudden hepatitis.

Interstitial pneumonia is accompanied by manifestations of fever, cough, shortness of breath, chest X-ray abnormalities, and EOSIN hyperlypes may occur.

Aseptic meningitis (fever, headache, nausea and vomiting, stiff neck, loss of alertness).

Narrow and/or obstruction accompanied by ulcers of small intestine and/or large intestine.

Pepper pattern.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Japrolox drugs contraindicated in the following cases:

Patients with digestive ulcer.

Patients have serious blood abnormalities.

Patients with serious liver dysfunction.

Patients with serious kidney dysfunction.

Patients with serious heart function.

Patients with a history of hypersensitivity to any ingredients of the drug.

Patients with or have a history of asthma caused by aspirin (the induction of asthma attacks with nonsteroidal anti -inflammatory analgesic, etc.).

Pregnant women in the final stage.

Precautions when used

Need to remember the fact that anti -inflammatory drugs treat symptoms and do not treat the cause of the disease.

When taking this medication in the treatment of chronic diseases (rheumatoid arthritis, osteoarthritis - joints) should be noted as follows:

Patients who are treating long -term drugs should be performed periodic tests in the laboratory (such as urine tests, hematological tests, liver function tests). If there is an abnormal notice, appropriate measures should be taken such as reducing the dose or stopping drugs.

Consider other treatments.

When taking this medication in the treatment of acute diseases, you should pay attention as follows:

Should take this medication when inflamed, pain and acute fever.

According to the principle of long -term use of similar drugs.

If there is a medication to treat the cause of the disease, it is advisable to prioritize treatment. Japrolox should be avoided when the purpose is not clear.

Pay attention to strictly control the patient's clinical manifestations to reduce the increase in side effects. There may be too much heat reduction, vascular collapse, cold limbs, etc. In patients when taking this medication, careful monitoring of the patient's clinical condition after taking the medication, especially in elderly patients with high fever or patients with depression.

Should be used simultaneously with unknown infections, appropriate antibiotics, and medication after careful consideration and strict control of patients, taking this drug in the treatment of inflammation caused by infection.

Should avoid using other anti -inflammatory analgesic drugs when possible.

Should minimize the medication and should be careful when taking the drug to reduce side effects, especially in elderly patients.

Risk of cardiovascular thrombosis: nonsteroidal anti -inflammatory drugs (NSAIDs), non -aspirin, using systemic tract, may increase the risk of cardiovascular thrombosis, including myocardial infarction and stroke, which can lead to death. This risk can appear early in the first few weeks of taking the drug and can increase over time. The risk of cardiovascular thrombosis is recorded mainly at high doses. Doctors need to periodically assess the appearance of cardiovascular events, even if the patient has no previous cardiovascular symptoms. Patients need to be warned of symptoms of serious cardiovascular events and need to see a doctor as soon as they appear. In order to minimize the risk of adverse incidents, the lowest daily daily dose is required in the shortest possible time.

The ability to drive and operate machinery

No report.

Pregnancy

only use this drug for women who are or have the potential to be pregnant when considering the previous benefits of treatment than any potential risk.

Breastfeeding period

Should avoid using this medication for breastfeeding mothers. If using the drug is considered necessary, should stop breastfeeding.

Drug interaction

Drugs

Manifestations, symptoms and treatment

mechanisms and risk factors

The anticoagulant effect of these drugs can be increased. Therefore, need to be cautious and reduce the dose if necessary.

The inhibitory effect of the drug in prostaglandin biosynthesis can lead to platelet aggregation inhibition and reduce coagulation. So increase the anticoagulant effect of these drugs.

The effect of reducing glucose - the blood of these drugs can be increased.

In general, simultaneously used with this drug, the high protein bond rate is 97.0% high as the loxoprofen or 92.8% such as its trans - OH is isomer, increasing the active ingredient concentration in the plasma of Glucoza reduction drugs - the blood is simultaneously with the high -protein ratio, enhances the effects of the second drug.

The effect of seizures of these drugs may be increased.

New generation Quinolone antibiotics inhibit GABA receptors, a neurotransmitter inhibitor in the central nervous system, and therefore can cause seizures.

methotrexate.

Methotrexate concentration in plasma can be increased, leading to decrease with an increase in the concentration of the drug in plasma that adds to the effect of methotrexate. Therefore, the dose should be reduced when necessary.

In general, it is thought that the excretion of the drug in the kidneys decreases with an increase in the concentration of drugs in plasma caused by prostaglandin inhibition.

Lithium lithium lithium products

Lithium concentration in plasma can be increased, leading to lithium toxins. Therefore, careful control of lithium concentration in plasma and decreased dose when necessary.

Anti -hypertension effects - diuretic of these drugs may be reduced.

General review of the inhibitory effect of the drug in prostaglandin biosynthesis leads to reducing the secretion of salt and water.

(Transfer inhibitors and Angiotensin II receptor antagonists).

The hypotension effect of these drugs may be reduced.

Renal function may be worse.

The inhibitory effect of the drug on the prostaglandin biosynthesis can reduce the effect of lowering the blood pressure of these drugs.

Trade, inhibitory effect of this drug on prostaglandin biosynthesis leads to reducing blood flow through the kidneys.

Storage

In a dry place, avoid light, the temperature does not exceed 30⁰C.

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