Join 1% antibiotice skin cream for fungal diseases, tinea versicolor (15g)

Dosage form Cream
Specifications Tube x 15g
Ingredient Clotrimazol

Ingredient

Composition information	Content
Clotrimazol	1%

Uses

indications

Josry 1% drug is indicated for on -site treatment of fungal diseases such as:

Candida albicans fungal disease. Canis. The mechanism of acting of clotrimazole is to link with phospholipids in the fungal cell membrane, changing the absorbent properties of the membrane, causing loss of intracellular essential substances leading to the destruction of mushroom cells.

Effective spectrum:

In vitro, Clotrimazole have the effect of restraining and killing fungi, depending on the concentration, with Trichophyton Rugbrum, Trichophyton Mentagrophytes, Epidermophyton Floccocum, Mircrosporum Canis and Candida species.

In addition, it also works to some gram -positive bacteria (Staphylococcus aureus, Streptococcus pyogenes), Gram -negative bacteria (bacteroides, gardnerella vaginalis), trichomomas. The tests of mushroom sensitivity with drugs do not help predict which mushrooms will respond to treatment.

Antibacterial or anti -parasitic activity also helps in clinically. The topical effect of the drug on the skin surface depends not only on the type of lesions and the mechanism of action of the drug but also on the viscosity, water dislike, acidity of the preparation.

Drug resistance:

Natural resistance with rare clotrimazole. Only a strain of Candida Guillidondri resistant to Clotrimazole. Azole resistance has gradually appeared when the treatment lasted for a long time and had failed treatment in end -stage HIV -infected people and cantidia infection in the mouth - the mouth or the esophagus. Common cross resistance between Azole.

pharmacokinetics

Clotrimazole used on the skin is very little absorbed into the blood.

Six hours after applying the cream and 1% Clotrimazole solution with radioactive isotope on the skin intact and on acute inflammatory skin, clotrimazole concentration varies from 100 micrograms/ml in the horny layer to 0.5–1 micrograms/ml in spikes and 0.1 micrograms/ml in subcutaneous tissue layer.

Before taking Join 1% antibiotice skin cream for fungal diseases, tinea versicolor (15g)

How to use

topical skin.

Dosage

Rinse the sick area (preferably wash with alkaline soap), wipe dry, then apply a thin layer of medicine, rub gently and evenly to absorb the drug completely.

Apply 2–3 times a day. The average treatment time is 1–3 weeks if tinea versicolor and 2–4 weeks for other fungal diseases.

Patients usually support within 1 week. Sometimes it is required to treat up to 8 weeks.

To avoid recurrence, patients need to keep personal hygiene.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose? Typically, it is unlikely to overdose in the form of Clotrimazole cream due to the low active ingredient concentration and the drug is used in the skin.

What to do when forgetting a dose?

Patients should apply on the skin as soon as they remember. If it is close to the time of application, skip and apply as usual. Do not apply medicine 2 times.

Side Effects

When using Josry 1%, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Local reactions include burning, irritation, allergic dermatitis due to contact, burning pain in the skin.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Josry 1% contraindicated in the following cases:

Hypersensitivity to one of the ingredients of the drug.

Be cautious when used

Do not use Clotrimazole for the treatment of systemic fungal infections.

Do not use clotrimazole oral pathways for children under 3 years old because they have not determined efficiency and safety.

If irritated or sensitive when using clotrimazole, medication and appropriate treatment must be stopped.

Must treat enough time although symptoms are relieved. After 4 weeks of treatment, if not supported again.

Report to the doctor if there is a sign of increased irritation in the topical area (red, itching, burns, blisters, swelling), signs of hypersensitivity.

Avoid sources of infection or re -infection.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

There is no enough research data on pregnant people for the first 3 months. This drug is only used for pregnant women in the first 3 months when the doctor is clearly indicated.

The period of breastfeeding

still does not know whether the drug is excreted through milk, cautious when used for nursing mothers.

Drug interaction

There has been no notice of the effect of copper or antagonism between clotrimazole and nystatin, amphotericin B or flucytosine in C. albicans.

Tacrolimus concentration in the serum of people with liver transplant increases when used simultaneously with clotrimazole. Therefore, Tacrolimus dose should be reduced according to demand.

Storage

Store at temperatures below 30ºC. Take the drug within 4 weeks after opening.

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Disclaimer

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