Jovan t 20 Cadila tablet treat erectile dysfunction (1 blister x 1 tablet)

Dosage form Box of 1 blister x 1 tablet
Specifications Tadalafil

Ingredient

Composition information	Content
Tadalafil	20mg

Uses

Indication

Jovan T 20 is indicated in case:

Treatment of erectile dysfunction.

Pharmacology

Tadalafil is a selective inhibitor, with restoration of Guanosine monophosphate (CGMP), especially on the enzyme phosphodiesterase tube 5 (PDE5).

When sexual stimulation causes local nitric oxide release, PDE5 inhibitors are added by Tadalafil to create increased CGMP levels in the cave. This leads to smooth muscle relaxation and blood flow into the penis tissue, thus creating an erection. Tadalafil has no effect in treating erectile dysfunction without sexual stimulation.

Pharmacokinetics

absorption

Tadalafil is easily absorbed after taken and the maximum maximum concentration in plasma (CMAX) is achieved at an average of 2 hours after taking the drug. Tadalafil's absolute bioavailability after oral use has not been determined.

Tadalafil's speed and absorption level are not affected by food, so Tadalafil can be used or not of the same food. The time to use the drug (in the morning compared to the evening after using 10 mg only) has no clinical influence on the speed and level of absorption.

Distribution

The average distribution volume is about 63 liters. Tadalafil is distributed to tissues. At treatment concentration, 94% Tadalafil in plasma is linked to protein. Linking with protein is not affected by renal function impairment.

Metabolism

Tadalafil is metabolized mainly by Cytochrom P450 (CYP) 3A4. The main metabolite in the circulation is methylcatecholl glucuronid. This metabolic substance works less than Tadalafil for PDE5 at least 13,000 times. Therefore, it is said to be inactive in the concentration of metabolic metabolites.

Elimination

The average oral clearance for Tadalafil is 2.5 l/hour and the average selling time is 17.5 hours in healthy people. Tadalafil is excreted mainly in the form of non -active metabolites, mainly in stool (about 61% of the dose) and at less than the urine (about 36% of the dose).

Before taking Jovan t 20 Cadila tablet treat erectile dysfunction (1 blister x 1 tablet)

How to use

oral medication. The drug is taken at least 30 minutes before sex.

Dosage

Starting dose is usually 10 mg x 1 time/day.

may increase the dose up to 20 mg x 1 time/day if the recommended dose is not enough to work.

Patients with renal failure

No dose adjustment in patients with mild to moderate renal failure.

For patients with severe renal failure, the maximum dose is 10 mg x 1 time/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Adultery effects are similar to the side effects that occur at lower doses.

In case of overdose, standard support measures should be applied. Bloody decentralization contributes significantly to the removal of Tadalafil.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Jovan T 20 you may experience some unwanted effects (ADR).

Common, ADR> 1/100

The immune system: hypersensitivity.

Nervous system: headache, fainting, migraine.

eyes: blurred vision.

Uncommon, 1/1000

Nervous system: convulsions, transient dementia.

Cardiovascular: Brushing chest drum, tachycardia.

Rare, ADR

The immune system: eagle.

Nervous system: stroke.

Eye: optic neuropathy, retinal blood vessels, visual market defects. Cardiovascular: unstable angina, ventricular arrhythmia, myocardial infarction.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

contraindicated

Jovan t 20 drug is contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug.

Patients who are using drugs of organic nitrate.

Pregnant and lactating women.

Severe liver failure.

Children under 18 years old.

Be cautious when used

Before starting the treatment of erectile dysfunction, it is necessary to consider the patient's cardiovascular condition, because there is a level of heart risk associated with sexual activity. Tadalafil has vasodilator properties, leading to mild and transparent blood pressure reduction and thus increases the hypotension effect of nitrate.

Cardiovascular events

Serious cardiovascular events, including myocardial infarction, heart mutations, unstable angina, ventricular arrhythmia, stroke, transient ischemic anemia, chest pain, chest drum and fast heartbeat, have been reported. Most patients reported on these events have previous cardiovascular risk factors.

Smart

There have been reports on fuzzy side effects in men using Tadalafil. Stop medication and consult your doctor if this side effect is encountered.

Sudden reduction or loss of hearing

Sudden hearing cases have been reported after using Tadalafil.

The ability to drive and operate machinery

No report.

Pregnancy

Contraindications for pregnant women.

Breastfeeding period

Contraindicated for breastfeeding women.

Interactive drug

Do not coordinate Tadalafil with organic nitrates.

Be cautious when coordinated with CYP3A4 inhibitors because of the risk of increased tadalafil levels.

Collaborate with HIV Protease inhibitors increases the level of absorption and semi -waste time of Tadalafil.

Be cautious when used simultaneously with medication to treat hypertension because of the risk of excessive hypotension.

Storage

Temperature does not exceed 30 ° C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.