Kabi Bidiphar metronidazol infusion solution for acute bacterial infections in the intestine, abdominal inflammation (500mg)

Dosage form Bottle x 100ml
Specifications Metronidazol

Ingredient

Thành phần cho 100ml

Composition information	Content
Metronidazol	500mg

Uses

Indications

Kabi metronidazol infusion solution indicated treatment in the following cases:

Treat cases of Trichomonas Vaginalis infection, Entamoeba Histolytica (acute gut and liver abscess), Dientamoeba Fragilis in children, Giardia Lamblia and Dracunculus Medinensis. Skin structure, central nervous system infection, blood infection and pericarditis. Coordinate with oral neomycin, or kanamycin to prevent surgery in people with colorectal surgery and gynecological surgery. Crohn's disease can work in the colon and rectum. Peptic ulcer - duodenal ulcer led by Helicobacter pylori (in combination with some other drugs).

Dynamic pharmacokinetics

Metronidazole often absorbs quickly and completely after injection. The half -life of Metronidazol in plasma is about 8 hours and the distribution of the water volume in the body (0.6 - 0.8 liters/kg).

about 10 - 20% of the drug is associated with plasma proteins. Metronidazole penetrates well into tissues and fluids, into saliva and breast milk. Treatment concentration is also achieved in cerebrospinal fluid.

metronidazole metabolizes the liver into hydroxy and acid -shaped metabolites, and eliminates through the urine partially in the form of glucuronid. The metabolites still have some pharmacological effects.

Before taking Kabi Bidiphar metronidazol infusion solution for acute bacterial infections in the intestine, abdominal inflammation (500mg)

How to use

only use Kabi metronidazol infusion solution.

Dosage

only use Kabi metronidazol infusion solution for patients who cannot take the drug. When the patient can drink, switch to a prescription drug.

Adults: intravenously 1.0 - 1.5 g/day divided into 2-3 times.

Children: intravenous infusion 20 - 30 mg/kg/day divided into 2-3 times.

Anaerobic infection room after surgery 20 - 30 mg/kg/day divided into 3 times. 10 - 15 mg/kg, infusion for 30-60 minutes, completed 1 hour before surgery, followed by 2 doses of intravenous injection 5 - 7.5 mg/kg at 6 and 12 hours after the first dose.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? The nerve effect of convulsions, peripheral neural inflammation has been reported after 5 to 7 days of use of 6 - 10.4 g of 2 days/time.

Treatment: There is no specific antidote. Symptomatic treatment and support.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Kabi metronidazol infusion solution, unwanted effects often depend on the dose. When using high and long -term doses will increase the harmful effects.

Common: Nausea, vomiting, anorexia, abdominal pain, diarrhea, uncomfortable metal flavor.

Uncommon: leukopenia.

Rare:

Sample: Loss of granulocytes.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Kabi metronidazole infusion solution in the following cases:

There is a history of hypersensitivity to Metronidazol or other nitro Imidazol conductors.

Be cautious when used

metronidazole has the effect of inhibiting alcohol Dehydrogenase and other alcohol oxidation enzymes. The drug has a mild disulfiram -like reaction such as hot face, headache, nausea, vomiting, abdominal spasms and sweating.

Metronidazole can cause immobility of Treponema Pallidum to create a false positive reaction of the Nelson test.

High doses of treatment for anaerobic and amoeba treatment and Giardia can cause sample organs and physical diseases.

Use drugs for women during pregnancy and lactation

Pregnant women:

Metronidazole through the placenta is quite fast, achieving a proportion of concentrations between the stem of the placenta and the mother's plasma is approximately 1. Some studies have announced the risk of increased monster when taking the drug in the first 3 months of pregnancy. Therefore, it is not advisable to use during the first time when pregnant, unless required.

breastfeeding women:

Metronidazole is excreted in breast milk quite quickly, breastfed babies may have plasma concentrations in plasma equal to about 15% of the mother concentration. Metronidazol should be stopped when treated with Metronidazol.

The effect of the drug on the ability to drive and operate machinery

The drug does not affect the driver and operate the machine.

Interactive drug

metronidazol increases the effects of anticoagulant oral medications (especially Warfarin), vecuronium.

metronidazol has a disulfiram -style effect. So do not use these two drugs simultaneously to avoid nervous effects such as psychosis, confusion.

Phenobarbital increases metronidazol metabolism.

Use Metronidazol for patients who are using lithium will increase the level of lithium lithium increased, toxic.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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