Kacetam Plus kacetam plus tablets treat brain diseases (10 blisters x 10 tablets)

Has a mental effect, improving learning ability and memory due to the impact on some neurotransmitters such as acetylcholin, noradrenalin, dopamine.

Has a protective effect against metabolic disorders due to ischemia by increasing brain resistance to oxygen deficiency.

Increase the mobilization and use of glucose without depending on the supply of oxygen, facilitating the pentose path and maintaining energy synthesis in the brain.

Reduces the possibility of platelet accumulation and in case of abnormal erythrocytes, the drug may cause red blood cells to recover the ability to deform and the ability to pass through capillaries. The drug has anti -vibration effect.

cinarizin

cinarizin is an antihistamine (H1). The majority of H1 antihistamine drugs also have anti -secretion effects of acetylcholin and sedation. Antihistamine drugs can block receptors at the end of the vestibular and inhibit the activity of histamine secretion to acetylcholin.

cinarizin is also a calcium antagonist. The drug inhibits blood vessel muscle muscle contraction by choosing calcium channels.

pharmacokinetic

piracetam

Piracetam is absorbed quickly and almost entirely in the digestive tract, the peak concentration in the serum reaches about 30 minutes after taken, the peak concentration in the cerebral brain fluid after taking the drug is 2 - 8 hours.

The distribution volume is about 0.6 liters/kg.

Piracetam implicitly on all tissues and can pass through the bloody barrier, placenta and membranes used in the kidney. The drug has high concentrations in the cerebral cortex, water town, water peak and hydraulic, cerebellum and the bottom of the bottom.

Half of life: In plasma is 4-5 hours, in cerebrospinal fluid is 6 - 8 hours.

Elimination: Piracetam is not attached to plasma proteins and is eliminated through the kidneys in the form of intact, more than 95% in urine.

cinarizin

After drinking, cinarizin achieved plasma peak concentrations from 2 to 4 hours. After 72 hours, the drug still eliminates urine. Another life of the drug in young volunteers is about 3 hours.

Can reduce the side effects of the drug by reducing the dose.

Can prevent chicken sleep and digestive disorders, often temporarily, by increasing the dose to the optimal level. Must stop the drug when the disease is worse or the symptoms of the percentage of long -term treatment for the elderly.

Note: Notify the doctor unwanted effects when using the drug.

Be cautious when using

Need to monitor kidney energy in kidney failure and elderly patients.

Dosage adjustment for patients with creatinine clearance coefficient

Creatinine clearance coefficient is 60 - 40 ml/minute: only 1/2 of normal dose.

Creatinine clearance coefficient is 40 - 20 ml/min: Use 1/4 of normal dose.

Like other antihistamines, cinarizin can cause epigastric pain. Taking medicine after meals can reduce stomach irritation.

To avoid long -term cinarizin in the elderly, because it can cause increased or appears of foreign symptoms, sometimes combined with depression in prolonged treatment.

Use drugs for women during pregnancy and lactation

Pregnant women

Piracetam can be through the placenta. Do not use this medication for pregnant people.

breastfeeding women

Do not use this medication for nursing mothers.

The effect of the drug on the ability to drive and operate machines

The drug can cause chicken sleep, especially at the beginning of the treatment. Must avoid jobs that need alertness. Do not use for drivers and operate machinery.

Medicinal interaction

can still continue the classic treatment of alcoholic (vitamins and sedatives) in the case of a person who lacks vitamins or agitated strongly.

There has been a case of interaction between piracetam and thyroid essence when used simultaneously: confusion, stimulation and sleep disorders.

In some patients, prothrombin time has been stabilized by warfarin again when using piracetam.

Alcohol, central nervous system inhibitors, three -round antidepressants: simultaneously used with cinarizin can increase the drowsiness of these drugs or cinarizin.