Kaflovo 500 khapharco medicine for bacterial infections, pneumonia, skin infections (10 blisters x 5 tablets)

Community pneumonia: 1 tablet, 1-2 times/day for 7 - 14 days. acute sinusitis: 1 tablet/day for 10 - 14 days.

Liver: Increased liver enzyme. nerve: Insomnia, headache. skin: itching, skin rash.

Uncommon, 1/1000

History of disease in the tendon due to a fluoroquinolon.

Pregnant and lactating women.

Be cautious when using

The drug contains lactose, so patients with rare genetic disorders in galactose tolerance, Lactose Lapp deficiency or Glucose absorption disorders - Galactose should not use this drug.

Fluoroquinolon antibiotics are associated with serious harmful reactions that can cause disabilities and non -recovery on different organs of the body. These reactions may appear simultaneously on the same patient.

Harmful reactions are often recorded including tendonitis, tendon, joint pain, muscle pain, peripheral neuropathy and adverse effects on the central nervous system of the island, anxiety, depression, insomnia, severe headaches and confusion. These reactions may occur within hours to a few weeks after using the drug. Patients at any age or no risk factors that exist before may have these harmful reactions.

Stop using the drug as soon as there are signs or first symptoms of any serious harmful reactions. In addition, avoid using Fluoroquinolon antibiotics for patients who have had serious reactions related to fluoroquinolon.

Special tendonitis is Achille, which can lead to tendons. This complication may appear at the first 48 hours, after starting the drug and may be both sides.

Tenditis occurs mainly in risks: people over 65 years old, using corticosteroids (including inhalation lines). These two factors increase the risk of tendonitis. Watch out, need to adjust the daily dosage of drugs in older patients according to glomerular filtration level.

Effects on the skeletal muscle system: Levofloxacin, as well as most other quinolons, can cause cartilage degeneration in gravity joints on many young animals, so it should not be used levofloxacin for children under 18 years old.

Myasthenia gravis: Caution should be cautious in patients with myasthenia gravis because the manifestations may get worse.

Effects on the central nervous system: There have been notifications on adverse reactions such as mental disorders, increased intracranial pressure, stimulating the central nervous system leading to convulsions, trembling, restlessness, headache, insomnia, depression, hallucinations, nightmares, intentions, intentions or action (rare) when using Quinolon groups, even first dosage. If these adverse reactions occur while using levofloxacin, it is necessary to stop the drug and take appropriate symptomatic management measures.

Be careful when used for people with central neurological diseases such as epilepsy, cerebral vascular sclerosis, ... because it may increase the risk of seizures.

Hypersensitivity reactions: sensitive reaction with many other clinical manifestations, even anaphylaxis when using quinolones, including levofloxacin. It is necessary to stop the drug as soon as there are the first signs of sensitive reaction and apply appropriate treatment.

Clostridium variety colitis: This adverse reaction is informed to many antibiotics including levofloxacin, which can occur at all levels from mild to life -threatening.

It should be noted to accurately diagnose the cases of melting occurrence during the time the patient is using antibiotics to take appropriate treatment.

Hypersensitivity to heavy -to -severe light has been informed to many Fluoroquinolon antibiotics, including levofloxacin (although up to now, this adverse reaction rate when using Levofloxacin is very low

Effects on metabolism as well as other quinolones, levofloxacin can cause sugar metabolism disorders, including hyperemia and hypoglycemia often occur in people with diabetes using levofloxacin simultaneously with a hypoglycemic drug or with insulin, so it is necessary to monitor blood sugar on this patient. If hypoglycemia occurs, levofloxacin should be stopped and properly handled.

Extend the QT distance on the electrocardiogram: Using Quinolones can cause a distance of qt on the electrocardiogram in some patients and some rarity of the arrhythmia, so it is necessary to avoid use in patients with long -term QT, patients with blood potassium, patients who are using anti -rhythmic drugs IA (Quinidine, Procainamid, etc.) Levofloxacin for patients who are in pace of arrhythmia such as slow rhythm and acute myocardial myocardial.

The ability to drive and operate machinery

The drug has an unwanted effect on the nervous system that causes dizziness, falling asleep, visual disorders, so it cannot be used for drivers and machinery.

Pregnancy

There are very few data from the use of levofloxacin in pregnant women. Animal studies do not indicate directly or indirectly about reproductive toxicity. However, because the drug has many risks of articular cartilage damage on young children, they do not use levofloxacin in pregnant women.

Breastfeeding period

has not measured levofloxacin levels in breast milk, but based on the ability to distribute into of Ofloxacin's breast milk, it can be predicted that it is also distributed into breast milk. Because the drug has many risks of articular cartilage damage on young children, not breastfeeding when using levofloxacin.

Drug interaction

The effect of other drugs on levofloxacin

Iron salt, antacids containing magnesi or aluminum: Levofloxacin absorption is significantly reduced when using iron salt, or antacids containing magnesi or aluminum with levofloxacin.

Theophylllin, fenbufen or nonsteroidal anti -inflammatory drugs: Brain seizures can be significantly reduced when used simultaneously with quinolon with theophyllin, nonsteroidal anti -inflammatory drugs, or drugs that reduce convulsions. When the presence of fenbufen concentration of levofloxacin is about 13% higher than when used.

Sucralfate: Levofloxacin's bioavailability is significantly reduced when used with sucralfat. If the patient uses both sucralfat and levofloxacin, it is best to take sucralfat 2 hours after taking Levofloxacin.

Probenecid and cimetidine: Through statistics, Probenecid and cimetidine have a significant influence on the elimination of levofloxacin. Levofloxacin's kidney clearance decreased by 24% due to cimetidine and 34% due to probenecid.

Other drugs: Clinically studied shows that levofloxacin pharmacokinetics are not affected when used simultaneously with calcium carbonate, digoxin, glibenclamide and ranitidine.

The effect of levofloxacin on other drugs

Cyclosporin: Cyclosporin's waste time increases 33% when used simultaneously with levofloxacin.

Vitamin K antagonistic drugs: Increasing blood clotting time (PT/INR) or bleeding, may be serious, which has been reported in patients treated with Levofloxacin in combination with vitamin K antagonists (eg warfarin). Therefore, it is necessary to monitor blood clotting tests in patients treated with antagonistic drugs.

The drug extends the QT interval: Like other Flouroquinolon antibiotics, should be cautious when taking Levofloxacin simultaneously with drugs that extend QT (such as anti -arrhythmic drugs IA, III, 3 -round antidepressants, macrolid, anti -arrhythmia). Due to no studies on the correlation of the drug, not mixed with this drug with other drugs.