Kagasdine capsules 20mg khapharco treat stomach ulcer, duodenum (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Omeprazol

Ingredient

Composition information	Content
Omeprazol	20mg

Uses

Indications

Kagasdine 20 drugs are indicated in the following cases:

Stomach ulcer, duodenal ulcer;

Gastroesophageal reflux;

Zollinger syndrome - Ellison.

Pharmacy

omeprazole inhibits the excretion of the acid of the stomach.

Mechanism: Inhibiting the restoration of enzyme system hydrogen-kali adenosin triphosphatase (also called proton pump) in the border cells of the stomach. Fast effect, prolonged but recovered. Omeprazol does not work on acetylcholine receptors or histamine receptors. Maximum effect after taking 4 days.

pharmacokinetic

omeprazol is completely absorbed in the small intestine after drinking for 3 to 6 hours. Biology is about 60%. Food does not affect the absorption of the intestine.

Omeprazol absorption depends on oral dose. The drug can increase its own absorption and bioavailability due to acidic excretion. The drug is highly attached to plasma proteins (about 95%) and is distributed in tissues, especially in the border cells of the stomach.

The bioactive use of the first dose is about 35%, but will increase by about 60% when taking the next day 1 dose. Although half -life is short (about 40 minutes), but the effect of inhibiting acid excretion is prolonged, so it can be used only once a day.

Omeprazole is almost completely metabolized in the liver, quickly excreted mainly through urine (80%), the rest according to feces. The metabolites are not active, but interact with many other drugs due to inhibiting the enzymes of the cytochrom P450 of liver cells.

The pharmacokinetics of the drug are not changed significantly in the elderly or the patient with renal function. In people with liver function, the bioavailability of the drug increases and the clearance of drugs decreases, but there is no accumulation of drugs and metabolites of the drug in the body.

Before taking Kagasdine capsules 20mg khapharco treat stomach ulcer, duodenum (2 blisters x 10 tablets)

How to use

Kagasdine 20 drugs for oral. Drink before breakfast or before going to bed.

Dosage

Sold -prescribed drugs, as directed by the physician.

Common dose for adults:

duodenal ulcer:

Take 1 tablet (20mg) x 1 time/day, take the drug for 2-4 weeks.

Take 1 tablet (20mg) x 1 time/day, take the drug for 4 - 8 weeks.

Initial dose: Take 1 capsule (60mg) x 1 time/day.

Maintenance dose: Take 1 - 6 capsules (20 - 120mg)/day, depending on clinical manifestations. (With a dose greater than 80mg/day, you should be divided into 2 drinks a day).

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

When overdose, only symptomatic treatment, no specific treatment.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Kagasdine 20, you may experience unwanted effects (ADR).

Common, 1/100

Neurology: headache, drowsiness, dizziness;

digestive: nausea, vomiting, sore throat, constipation.

Uncommon, 1/1000

Body: Insomnia, fatigue;

Skin: urticaria, itching, rash.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Kagasdine 20 drugs are contraindicated in cases of sensitivity to omeprazol. Hypersensitivity to the ingredients of the drug.

Be cautious when using

Before giving people with stomach ulcers using omeprazol, it must eliminate her malignant tumor because the drug can cover the symptoms, so it is late to diagnose.

The ability to drive and operate machinery

The drug has unwanted effects on the nervous system causing headaches, drowsiness, dizziness should be used for drivers and machinery.

Pregnancy

There is no specific research document on this issue, so it should not be used for pregnant women.

Breastfeeding period

There is no specific research document on this issue, so it should not be used for breastfeeding women.

Drug interaction

omeprazole may increase the level of Ciclosporin in the blood.

omeprazole increases the effect of antibiotic eradication H.pylori.

Omeprazole inhibits the metabolic of drugs metabolized by the enzyme system in the liver's cytocrom P450 and can increase the concentration of diazepam, phenytoin and warfarin in the blood. The metabolism of diazepam makes the effect of the drug longer. With a dose of 40mg/day omeprazol inhibits phenytoin metabolism and increases the concentration of phenytoin in the blood, but the omeprazol dose of 20mg/day has much weaker interaction. Omeprazol inhibits the metabolism of warfarin, but rarely changes bleeding time.

Omeprazol increases Dicoumarol's anticoagulant effect.

Omeprazol reduces nifedipine metabolism, at least 20% and may increase the effects of nifedipine.

Clarithromycin inhibits omeprazol metabolism and makes omeprazol levels double.

Storage

less than 30 ° C. Cool dry place, avoid light.

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