Kalmeco 500µg Kalbe capsules treat peripheral neuropathy due to vitamin B12 deficiency (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications mecobalamin

Ingredient

Composition information	Content
mecobalamin	500mcg

Uses

indications

kalmeco is indicated for treatment of peripheral neuropathy due to vitamin B12 deficiency.

Pharmacokological

kalmeco contains mecobalamin, a homogeneous substance of vitamin B12.

mecobalamin participates in the metabolism of protein and nucleic acid.

Mecobalamin is the only homogeneous substance of B12 involved in the methylation reaction in the human body. Mecobalamin facilitates the methylation process of T-RNA, which is very important in the process of protein synthesis and homocystein conversion into methionin.

Precaessing studies on animals with mice show that mecobalamin has an impact on the activity of the nervous system.

mecobalamin promotes recovery processes for atrophy muscles by stimulating large hip nerves. There is also the effect of repairing damaged nerve cells in case of encephalitis and nerve inflammation in animals.

These effects are due to mecobalamine that enhances the synthesis of protein and nucleic acid of the nerve and facilitates the process of spinal cord formation.

pharmacokinetics

Single dose

When using a single dose of methyl-cobalamin (Mecobalamin) for volunteers who are healthy men with a dose of 120 µg and 1500 µg by oral, the peak concentration of vitamin B12 in plasma is achieved after 3 hours and depends on the concentration.

Semi -selling time, peak concentration in plasma and dauc (the difference in the area under the concentration - time curve) after taking the 12 -hour drug is shown in the following table.

There are 40 - 80% of the total amount of vitamin B12 in the urine after taking the 24 -hour drug excreted within the first 8 hours.

Dosage: 120 Ug.

TMAX (GLO): 2.8 ± 0.2.

CMAX peak concentration (PG/ml): 743 ± 47.

CMAX peak concentration (%): 37 ± 15.

The area under the concentration curve - Time of ĐOC120 (PG -VN/ML): 5.1 ± 2.1.

Time for sale/2 (hours): Na.

Dosage: 1500 Ug.

TMAX (GLO): 3.6 ± 0.5.

CMAX peak concentration (PG/ml): 972 ± 55.

CMAX peak concentration (%): 255 ± 51.

The area under the concentration curve - Time of ĐOC120 (PG -VN/ML): 36.0 ± 7.9.

Selling time of Ti/2 (hours): 12; 5.

Dosage is repeated

Methyl cobalamin repeated dose for volunteers is a healthy male with a daily dose of 1500 µg for 12 consecutive weeks and determines the change of vitamin B12 concentration to 4 weeks after taking the last dose.

The serum concentration increases in the first 4 weeks of taking the drug, reaching the concentration of about 2 times the original value.

After that, the drug concentration increased slowly and reached the peak concentration of about 2.8 times the initial value after 12 weeks of taking the drug. The concentration of the drug decreased after the last dose (12 weeks) but still about 1.8 times higher than the original value after 4 weeks of stopping the drug.

Before taking Kalmeco 500µg Kalbe capsules treat peripheral neuropathy due to vitamin B12 deficiency (10 blisters x 10 tablets)

How to use

Take oral use.

Dosage

Adults

The total dose is 1500 µg per day, dividing 3 times (each time 1 tablet 500 µg).

Dosage can be adjusted according to the age of the patient and the severity of the disease.

What to do when overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Kalmeco 500 µg, you may experience unwanted effects (ADR).

There may be some symptoms such as nausea, loss of appetite, appetite, diarrhea and some other digestive system disorders.

Notice to the doctor the unwanted effects encountered during treatment.

Warnings

Contraindicated

Kalmeco 500 µg contraindicated drug used for the following cases:

Patients with a history of allergies to mecobalamin or any ingredients of the drug.

Be cautious when using

During treatment, if the patient does not respond to the drug, should stop using Kalmeco.

This drug is easy to decompose after direct contact with light, so it should be used immediately after opening the drug box.

Time to use the drug should last for more than 1 month if the clinical response has not been completely improved due to vitamin B12 deficiency.

The ability to drive and operate machinery

There is no evidence that the drug affects the ability to drive and operate machinery.

pregnancy and lactation

There are no complete studies on the safety and effectiveness of the use of drugs for pregnant and lactating women. Therefore, only Kalmeco is used for pregnant or lactating women when they have considered the benefits of treatment and risks may occur.

Interactive drug

The absorption of the drug may be reduced when there is the appearance of para-aminosalicylic acid, colchicin, biguanide, neomycin, cholestyramin, potassium chloride, methyldopa and cimetidine.

Patients treated with chloramphenicol may be less responding to Kalmeco.

Serum concentration may be reduced when taking oral contraceptives. These interactions do not seem to cause clinical effects.

Anti -metabolic substances and most antibiotics disabled vitamin B12 quantitative tests by microorganisms.

Storage

Store at temperatures below 30 ° C, avoiding light.

Other drugs

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