Kavasdin 10mg kavarco tablets treat hypertension in stable angina (10 blisters x 10 tablets)

Anti -hypertension effect by directly relaxing smooth muscles around the peripheral artery and has less effect on myocardial calcium channel. Therefore, the drug does not conduct the atrial transmission in the heart and does not adversely affect the muscle contraction force.

Amlodipin also works well, which is to reduce kidney blood vessel resistance, thus increasing blood flow in the kidneys and improving kidney function. Therefore, the drug can also be used to treat people with heart failure.

Amlodipin has no adverse effects on plasma lipid concentrations or glucose metabolism, so it can be used amlodipine to treat hypertension in people with diabetes. However, there are no long -term clinical trials to prove that Amlodipine has the effect of reducing death.

In many countries, the standard treatment to protect patients with hypertension from stroke and death is still beta and diuretics, these drugs are first selected for treatment. However, Amlodipin can be used in combination with beta blockers along with thiazid or diuretics and with angiotensin conversion enzyme inhibitors.

Amlodipin works well when standing, lying as well as sitting and while working. Because amlodipine is slowly acting, there is less risk of acute or reflective hypotension.

Anti -angina effect:

Amlodipin relaxes peripheral arteries, thus reducing all the obstacles in the peripheral circuit (the posterior burden).

Because the heart frequency is not affected, the burden of the heart reduction of the heart decreases, along with reducing the need for oxygen and energy to the heart muscle.

This reduces the risk of angina.

This vasodilation increases oxygen supply to patients with cramped angina (Prinzmetal -type angina).

This reduces nitroglycerin demand and in this way, the risk of nitroglycerin resistance may decrease.

Time for anti -angina effect is 24 hours. People with angina can use amlodipine in combination with beta blockers and always use with nitrate (basic treatment of angina).

pharmacokinetics

Biological use of amlodipin when taking about 60 to 80% and not affected by food. The maximum concentration in plasma is achieved after drinking within 6 to 12 hours.

Amlodipine has a large distribution and more than 95% in combination with plasma proteins. Stable plasma concentrations reach 7 to 8 days after taking the drug once a day. The integral distribution is approximately 21 liters/kg body weight and drugs linked to high plasma proteins (over 98%).

The clearance in plasma is normal at about 7 ml/min/kg body weight due to excretion mainly through metabolism in the liver. The metabolites are inactive and excreted through the urine. The relatively 30 to 40 hours of sale time. In people with liver failure, Amlodipine's exhaust time increases, so it may be necessary to reduce the dose or extend the time between the dose.

Notify the physician the unwanted effects when using the drug.

Precautions when using

Use carefully for people who reduce liver function, aortic stenosis, cardiac failure after acute myocardial infarction.

Use drugs for women during pregnancy and lactation

Pregnant women

Amlodipin may inhibit early uterine contractions. However, the drug has no adverse effects on the birth process. The risk of oxygen deficiency must be taken into account if causing hypotension in the mother. This is a common risk when using drugs to treat hypertension, they can change the blood flow due to peripheral vasodilation.

In experimental animals, Calci chenoc can cause teratogenicity in the form of bone defects. Therefore, avoid using amlodipine for special pregnant people in the first 3 months of pregnancy.

breastfeeding women

There has been no notice to assess Amlodipin's accumulation in breast milk. So with caution should stop breastfeeding when treated with amlodipine.

The effect of the drug on the ability to drive and operate machinery

The drug often causes unwanted effects such as headache, dizziness, fatigue, so it cannot be used for drivers and operating machinery.

Medicinal interaction

Anesthesia increases the anti -hypertension effect of amlodipine and can make blood pressure more sharply.

Not used simultaneously with nonsteroidal anti -inflammatory drugs, especially indomethacin can reduce the anti -hypertension effect of amlodipine due to prostaglandin synthesis or sodium and fluid.

High -linked drugs with protein (such as Coumarin, Hytantoin, ..) must be used carefully with amlodipin, because amlodipine is highly linked to protein, the concentration of the above drugs in free form can change serum ash.