KEFCIN 125 DHG nuggets treat respiratory infections, urinary tract (24 packs)

Dosage form Box of 24 packs x 1.5g
Specifications Cefaclor

Ingredient

Composition information	Content
Cefaclor	125mg

Uses

indications

Kefcin 125 drugs are indicated in the following cases:

Treatment of respiratory infections caused by sensitive bacteria: acute otitis media, acute sinusitis, sore throat, tonsillitis recurrence many times; Pneumonia, chronic bronchitis during the evolution. is the antibiotic cephalosporin group of 2nd generation, has the effect of killing bacteria due to inhibiting the synthesis of bacterial cell walls.

Cefaclor has a Vitro printing effect on gram-positive bacteria similar to cephalotin, but has a stronger effect on Gram-negative bacteria, especially with Haemophilus Influenzae and Moraxella Catarrhalis, even with H.influenzae and M.Catrhalis producing beta-lactamase. Cefaclor In Vitro, which works for the majority of the following bacteria: Staphylococcus, including the strains producing penicillinase, positive coagulase, negative coagulase; Streptococcus pneumoniae; Streptococcus Pyogenes (Streptococcus Beta Group A); Moraxella CatVrhalis, Haemophilus Influenzae (including strains producing beta-lactamase, ampicillin resistance); Escherichia coli; Proteus Mirabilis; Klebsiella spp; Citrobacter Diversus; Neisseria gonorrhoeae; Propionibacterium acnes and bacteroides spp. (except bacteroides fragilis); peptococcus; peptostreptococcus.

Cefaclor does not work for Pseudomonas spp. or acinobacter spp., Staphylococcus resistant to methicillin and all Enterococcus strains.

Dynamic pharmacokinetics

absorption: Cefaclor is absorbed very well after drinking. Food slows down Cefaclor's absorption, but the total amount of drugs is absorbed unchanged.

Distribution: about 25% Cefaclor binds to plasma proteins. Cefaclor is widely distributed throughout the body, passes through the placenta and excretes in low concentrations.

Elimination: Cefaclor's waste time in plasma is from 30 to 60 minutes, this time is usually longer in people with renal function.

If the kidney function is completely lost, the sale time lasts from 2.3 to 2.8 hours. Cefaclor quickly excreted through the kidneys. Probenecid slowed Cefaclor excretion. A little cefaclor is excreted through hemorrhage.

Before taking KEFCIN 125 DHG nuggets treat respiratory infections, urinary tract (24 packs)

How to use

oral medication. Take medicine when hungry. Mix medicine with sufficient water (about 5–10 ml of water for 1 pack), stir before drinking.

Dosage

Adults: Common dose of 250 mg x 3 times/day.

Sore throat, bronchitis, tonsillitis, skin and soft tissue infections, lower urinary tract infections: 250–500 mg x 2 times/day or 250 mg x 3 times/day.

For more severe infections, dose of 500 mg x 3 times/day. Maximum dose of 4 g/day.

Need to adjust the dose for people with severe kidney failure:

Creatinine clearance 10–50 ml/min, using 50% common doses.

Creatinine clearance below 10 ml/min, using 25% of the common doses.

Patients with hemorrhage must be used: The starting dose of 250–1000 mg before hemorrhage and maintenance of treatment dose of 250–500 mg every 6–8 hours, during the time between the separation.

Elderly: Dosage like adults.

Children: 20–40 mg/kg/day, divided into 2–3 times.

otitis media in children: 40 mg/kg/day, divided into 2–3 times, but not more than 1 g.

Treatment of bacterial infections caused by beta hemolytic streptococcus with cefaclor for at least 10 days.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? There is no need to wash the stomach, the intestine unless taken Cefaclor at a dose of 5 times the normal dose. Protection of respiratory tract for patients, ventilation support and infusion.

Reduce the absorption of drugs by giving activated carbon many times. You can wash your stomach and add activated carbon or use activated carbon. The diuretic benefits, the abdominal duct ratio or dialysis have not been determined to be beneficial in the treatment of overdose.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using KEFCIN 125, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Measles, diarrhea, Eosin hyperps.

Uncommon, 1/1000

Test Coombs directly positive, increase lymphocytes, leukopenia, nausea, vomiting, itching, urticaria, genitals, vaginitis, candidiasis.

Rare, 1/10000

Anaphylactic reactions, fever, Stevens - Johnson syndrome, Lyell syndrome, all -body pustules, serum -like reactions (common in children than adults).

platelet reduction, hemolytic anemia, fake colitis, hepatic enzyme, hepatitis and jaundice of cholestasis, interstitial nephritis.

Sleek to increase blood urea or serum creatinine, epilepsy, incite, headache, restlessness, insomnia, confusion, dizziness, hallucinations, sleep, joint pain.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Kefcin 125 drug contraindicated in the following cases:

Patients with a history of allergies to antibiotics of cephalosporin.

Be cautious when using

Precautions when used for patients with a history of hypersensitivity to cephalosporin, especially with cefaclor, or with penicillin.

Cefaclor for a long time can cause fake colitis, caution for patients with a history of gastrointestinal disease, especially colitis. People with severe impaired renal function, need to monitor kidney function when long -term treatment or other drugs that affect kidney function (such as aminoglycoside, furosemide ...); Patients with urinary phenylceton (due to Aspartam).

Diagonal blood transfusion reaction or testing cops in infants whose mothers used cefaclor before birth may be positive for drugs. Find the urinary glucose with false reducing agents.

The ability to drive and operate machinery

Caution when driving and operating machinery.

Pregnancy

There is no complete study in pregnant women, so Cefaclor is only specified in pregnant women when really necessary.

The period of breastfeeding

Cefaclor concentration in breast milk is very low. The impact of the drug on breastfeeding is unknown, but should pay attention when the baby has diarrhea, the breast -up when breastfeeding uses cefaclor.

Interactive drug

In patients with simultaneous use of cefaclor and warfarin, it is necessary to monitor prothrombin time and adjust the dose if necessary.

Probenecid inhibits cefaclor excretion in serum.

Cefaclor's simultaneous use with aminoglycoside antibiotics or Furosemide diuretic increases the toxicity of the kidneys.

Storage

In a dry place, the temperature does not exceed 30ºC, avoiding light.

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