Ketosan Hasan Tablets prevent bronchial asthma, treat allergic rhinitis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Ketotifen

Ingredient

Composition information	Content
Ketotifen	1mg

Uses

indications

Ketosan drug is indicated in the following cases:

Preventing bronchial asthma (asthma, asthma, asthma in the case of seasonal fever and allergic bronchitis). At the beginning of treatment should continue to use basic asthma medications: bronchodilator, theophyllin or corticosteroids.

Treatment of allergic rhinitis, systemic allergies, urticaria, atopic dermatitis, rashes, allergic conjunctivitis.

Note: Ketotifen is not indicated to treat acute asthma attacks.

Pharmacokology

Ketotifen is a non -compatible histamine inhibitor (H1 - receptor) inhibitors, relatively selective and a mast cell protective agent. Ketotifen is an oral medication that has the main effect on the respiratory system, is a medication for asthma without bronchodilator and has anti -allergic effect.

Inhibit the release of chemical mediators that cause allergens from mast cells and related cells in allergic reactions such as histamine, leukotrien C4 and 04 (SRS - A) and PAF.

H1 - histamine receptor inhibitors and phosphodiesterase inhibitors and the results increase the content of the Camp in Mast cells.

Preventing the progression of respiratory allergies, inhibiting PAF platelet activation (platelet activation) or due to nerve stimulation after using sympathetic stimulants; Preventing the gathering of eosinophil and platelets due to the respiratory tract, inhibiting the increase in the eosinophil, thus inhibiting the eosinophil line into the inflammatory place.

Long -term treatment effect on mild allergy bronchial asthma has been shown in clinical trials. Ketotifen continuous use every day helps reduce frequency, severity and prolonged symptoms of asthma and asthma attacks, helping to reduce the daily needs of coordinated asthma medications (theophylllin, β2 ...) without reducing lung function (FEV1, FVC and PEFR).

Ketotifen does not work to treat acute asthma attacks.

Pharmacokinetics

absorption

Ketotifen is well absorbed through the gastrointestinal tract (≥ 60%) after drinking. But bioavailability is only about 50% due to the first metabolism of the liver. The peak concentration in plasma is achieved after 2-4 hours, the absorption time is 1 hour. Food does not affect the bioavailability of the drug.

Distribution

The ratio of cohesion to plasma protein is 75%.

Metabolism

Ketotifen experienced the first liver effect (approximately 50%). Main metabolites in plasma and urine in the form of ketotifen - n - glucuronid. The metabolism of the drug in children is similar to adults but the clearance is higher. Therefore, in children> 3 years old, daily dose is similar to adults. When it is necessary to use drugs for children

Elimination

Ketotifen is eliminated through 2 sections:

Semi -cancellation time T1/2:

Distribution phase: 3 - 5 hours.

Erimization phase: 21 hours.

Ketotifen excreted mainly through urinary tract: 1% of the original form and 60-70% of the metabolic form is not active within 48 hours. The waste time is about 21 hours.

Before taking Ketosan Hasan Tablets prevent bronchial asthma, treat allergic rhinitis (3 blisters x 10 tablets)

How to use

Take oral use.

The treatment time depends on the severity of the disease, without special limits, usually not less than 2-3 months.

The treatment should last for at least a few weeks to be effective. Complete clinical effects are usually achieved after 10 weeks of treatment. Therefore, for patients who do not respond satisfactorily with treatment for the first few weeks, they should continue to maintain treatment for at least 2-3 months. If it is necessary to stop using ketotifen, the dose must be reduced slowly for 2-4 weeks before stopping the drug and the symptoms of asthma may reappear.

Combined treatment: Room effect is achieved after using Ketotifen 8 - 12 weeks, requiring appropriate prolonged treatment time. Therefore, the drug should not be reduced before the end of this period.

Dosage

Adults, adults and children> 3 years: In the first 3-4 days of treatment: 1 tablet (1 mg) x 1 time/day in the evening when eating. In the following days, take 1 capsule (1 mg) x 2 times/day in the morning and evening when eating.

For adults and children> 10 years old: If the treatment effect is not good after 4 weeks of treatment, the maximum dose can be increased to 2 mg (2 tablets) x 2 times/day.

Children 6 months - 3 years old (if necessary): Use 0.5 mg x 2 times/day (recommended use of syrup to drink).

In case of sensitivity to the sedative activity of preparations (drowsiness, sleep, drowsiness), should start with 1/2 dose (0.5 - 1 mg in the evening) in the first few days of treatment and then increase the dose slowly.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Symptoms of acute poisoning include drowsiness, chicken, drowsiness, confusion, dizziness, disorientation, vomiting, shortness of breath; Heart fast and hypotension, convulsions, especially in children; too excited in children; fainting, coma.

Management:

Can lavage or use activated carbon.

If necessary, symptomatic treatment or specific treatment and checking the cardiovascular system, using cholinergic anti -cholinergic physostigmin, taking diuretics; If stimulated or shocked, use a short -action barbiturate or benzodiazepin.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using ketosan, you may experience unwanted effects (ADR).

Side effects on the gastrointestinal tract include nausea, vomiting, diarrhea, epigastric pain.

Common, ADR> 1/100:

Central nervous system: Inhibit the central nerve with different effects from drowsiness to deep sleep, and include fatigue, dizziness, dizziness. These symptoms may decrease after a few days of treatment.

Uncommon, 1/1000

Central nervous system: stimulating the central nervous system (especially with high doses, children and the elderly) such as prone to stimulation, insomnia, irritability, impatience.

Rare, 1/10000 ≤ ADR

Blood disorders: granulocytosis, leukopenia, hemolytic anemia, thrombocytopenia.

Unknown frequency

Cardiovascular: Brushing the chest drum, arrhythmia;

skin: skin rash, urticaria, serious skin reaction (diverse pink, Stevens Johnson syndrome); kidney: cystitis; liver: hepatitis;

Other: Increasing cravings and weight gain, headache, mental impairment, muscarinic mental such as dry mouth, increased bronchial secretion, blurred vision, difficulty or urinary retention, constipation, gastroesophageal reflux; Convulsions, sweating, muscle pain, extras, tremor, sleep disorders, depression, tinnitus, hair loss, reducing blood pressure.

Instructions on how to handle ADR:

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated:

Ketosan drugs contraindicated in the following cases:

Hypersensitivity to Ketotifen and other ingredients of the drug.

Pregnant women in the first 3 months or lactation.

Caution when using

should not stop using the sudden use of symptomatic medications and preventing asthma attacks (Xanthin derivatives, β2, sodium chromoglycate, corticosteroids ...) When starting to use ketotifen, it is recommended to continue treating for at least 2 weeks after using ketotifen. Do not use ketotifen to treat acute asthma attacks.

Very rarely occur convulsions while using Ketotifen. However, Ketotifen may lower the threshold of seizures. Should be careful when taking the drug for patients with a history of epilepsy.

In the treatment of adrenal insufficiency for patients with corticosteroid therapy, the dose must be reduced or increased as directed by the doctor in batches.

In the case of infection during the treatment with ketotifen, special antibacterial treatment should be supplemented.

The ability to drive and operate machinery

Do not use drugs for people who operate the train, machinery due to the central neurological inhibitor and have side effects dizziness, dizziness, drowsiness ...

Pregnancy

Ketotifen does not affect pregnant animals and the development of the fetus before and after birth at the dose of treatment. However, safety in pregnant women has not been determined. Therefore, contraindicated for women who are pregnant in the first 3 months, from the 4th month onwards only use Ketotifen when really necessary.

breastfeeding period

Ketotifen is excreted through breast milk, so the mother must stop breastfeeding if indicated Ketotifen.

Drug interaction

Ketotifen increases the sedative effects of central neurological inhibitors including alcohol, barbiturates, opioid analgesics, sedatives, sleeping pills, muscle relaxants, anti -epileptic drugs ...

Ketotifen increases the antiviral effect of Muscarinic drugs such as Atropin, 3 -round antidepressants and Mao inhibitors.

There is an opinion that Ketotifen covers signs of damage caused by drugs that causes the ears such as aminoglycoside antibiotics.

Avoid use in combination with oral medications for diabetes treatment because it can increase thrombocytopenia (reducing the number of temporary platelets).

No interaction with normal asthma medication.

Storage

In a dry place, less than 30 ° C.

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