Ketosteril Fresenius Kabi prevents and treats chronic kidney failure (5 blisters x 20 tablets)

Dosage form Box of 5 blisters x 20 tablets
Specifications Leucine, Calcium, L-Threonine, L-Tryptophan, Histidine, L-Tyrosine, Nitrogen, Isoleucine, Cystine

Ingredient

Composition information	Content
Leucine	101mg
Calcium	50mg
L-Threonine	53mg
L-tryptophan	23mg
Histidine	38mg
L-Tyrosine	30mg
Nitrogen	36mg
Isoleucine	67mg
Cystine	105mg

Uses

indications

Ketosteril drugs are indicated in the following cases:

Prevention and treatment of disorders or impaired protein metabolism in chronic renal impairment, when the amount of protein in the diet is limited to less than 40 g/day (for adults). Often indicated for patients with glomerular filtration level (GFR) below 25 ml/min.

Pharmacokology

Ketosteril is used to provide nutrition in the treatment of chronic kidney disease. The use of Ketosteril allows the introduction of essential amino acids while ensuring limited to nitrogen amino acids.

After eating, keto-analogues and hydroxy-analogues are metabolized by using endogenous amino amino amino acids, thus reducing the formation of urea because the amino groups have been reused. The concentration of accumulated urea toxins is therefore reduced. Keto and/or hydroxy acids do not increase the filter for the remaining nephron.

Ketoacid supplements have a positive effect in limiting phosphate and secondary hyperthyroidism due to kidneys and also improves the condition of osteoporosis due to kidney. The use of Ketosteril in combination with a diet reduces protein also reduces the amount of nitrogen being put into the body to avoid bad consequences due to insufficient protein and malnutrition.

Dynamic pharmacokinetics

Dynamic in plasma of amino acids and the integration of amino acids in the metabolic forms that have been clearly defined. However, it should be noted that in patients with blood urea, the change of disorders of plasma is not considered to depend on the absorption of the body of amino acids (when there is no problem of absorption), but due to the hocoring after absorption of disorders in the early stage of the disease.

absorption

The gastrointestinal absorption is very fast.

Distribution

On healthy individuals, there is an increase in the concentration of serum ketoacids for about 10 minutes after drinking ketosteril. The concentration of these ketoacids is about 5 times higher than the beginning. The peak concentration reaches about 20 - 60 minutes and the normal concentration returns after about 90 minutes.

Metabolism

The simultaneous increase in the concentration of ketoacid and the corresponding amino acids in the serum indicates that the metabolism of ketoacid is very fast. According to the natural transformation path of ketoacids in the body, the Ketoacid provides external supply quickly involved in metabolic processes. Ketoacid follows the transformer path like other amines.

Elimination

There is currently no specific research on the elimination of ketoacids.

Before taking Ketosteril Fresenius Kabi prevents and treats chronic kidney failure (5 blisters x 20 tablets)

How to use

Take usage: Take oral use.

Medication time: Ketosteril tablets can be used for a long time if the glomerular filtration level (GFR) is below 25 ml/minute, and the amount of protein in the daily diet must be limited below 40 g (for adults).

Dosage

If there is no other indication: use 3 times a day, 4 - 8 capsules each time, take it right before meals, this dose is used for adults (weighing about 70 kg). Do not chew the tablet.

Use drugs along with food that increases the absorption and metabolism of amino acids in the drug ingredient.

There is no research document about using this drug for children.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose?

How to deal with overdose drugs:

Actively monitor for timely management measures.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Ketosteril, you may experience unwanted effects (ADR).

Common, ADR> 1/100

No report.

Uncommon, 1/1000

No report.

Very rare ADR

Metabolism, nutrition: hypercalcemia.

Need to reduce the amount of vitamin D provided if the phenomenon of hypercalcemia occurs. If the blood calcium level is still increasing, the dose of ketosteril should be reduced as well as the drugs in other calcium ingredients.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Ketosteril drugs contraindicated in the following cases:

Patients with hypersensitivity to any ingredients of the drug.

Patients with hypercalcemia.

Patients with amino acid metabolism disorders.

Be cautious when using

Need to regularly monitor the calcium level in serum. Make sure the supply is full of calories.

There is no data on this medication for children.

Be cautious when using drugs for patients with metabolic disorders (phenylketonuria), because in the composition of the drug has phenylalanin.

Pay attention to monitoring phosphate levels in serum if ketosteril is simultaneously used with aluminum hydroxid.

The ability to drive and operate machinery

Use Ketosteril does not affect or negatively affect the ability to drive and operate machinery.

Pregnancy

still does not have enough clinical data on the use of ketosteril in pregnant women, should only use drugs if the benefits are superior to the risk.

Results of animal studies show that Ketosteril has no harmful effects directly or indirectly for pregnancy, the embryo process develops before birth.

Be careful when taking medication for pregnant women.

Breastfeeding period

There is no experience in using drugs in nursing women.

Drug interaction

Treatment along with other calcium -containing drugs can lead to an increase in pathology or overdue serum calcium concentration. The drugs that make compounds are difficult to dissolve with calcium (such as tetracyclin, quinolin - such as ciprofloxacin and norfloxacin as well as iron, flourid or estramustin -containing drugs) should not be used at the same time as Ketosteril to avoid affecting the absorption of active ingredients.

Time to use Ketosteril and these drugs should be at least 2 hours apart. If using ketosteril, serum calcium concentration increases, sensitivity to glycosides that act on the heart and the risk of arrhythmia can also increase.

Because Ketosteril has the effect of improving the clinical condition of urea, the treatment if there is a hydroxide aluminum is reduced. Pay attention to reducing serum phosphate concentration.

Storage

Store at a temperature not exceeding 30 ° C.

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