Ketovital Gia Nguyen medicine prevents and treats chronic renal failure (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Isoleucine, leucine, phenylalanine, valine, methionin, l-lysin, l-threonin, l-histidin, l-tyrosin

Ingredient

Composition information	Content
Isoleucine	67mg
Leucine	101mg
Phenylalanine	68mg
Valine	86mg
Methionin	59mg
L-lysin	105mg
L-Threonin	53mg
L-histidin	38mg
L-Tyrosin	30mg

Uses

indications

Ketovital drugs are indicated to prevent and treat disorders or impaired protein metabolism in patients with chronic renal impairment, when the amount of protein in the diet is limited to 40 g/day (for adults). Often indicated for patients with glomerular filtration level (GFR) below 25 ml/min.

Pharmacokic

Ketovital is used to provide nutrition in the treatment of chronic kidney disease.

The use of ketovital allows to put into essential amine acids, while ensuring limited to nitrogen amine acids.

After eating, α-ketoisoleucine calcium, α-ketoleucine calcium, α-ketophenylalanine calcium, α-ketovaline calcium, α-hydroxymethionine calcium are metabolized using endogenous amine from non-essential amine acids. Therefore reducing the formation of UREA because amine groups have been reused. The concentration of accumulated Urea toxins is therefore reduced.

Keto and hydroxy acids do not increase filter for the remaining nephron. The supplements with ketoacid have a positive effect in limiting the increase in phosphate and the secondary hyperthyroidism due to the kidneys; At the same time, it also improves osteoporosis due to kidney. The use of Ketovital combined with a protein -reducing diet also reduces the amount of nitrogen being put into the body, in order to avoid bad consequences due to insufficient protein and malnutrition.

Dynamic pharmacokinetics

Dynamic in plasma of amine acids and the integration of amine acids in the formed metabolic forms are clearly defined. However, it should be noted that in patients with blood urea, the change of disorders of plasma is not considered as depending on the absorption of the body of amine acids (when there is no problem of absorption), but due to the hocoring after absorption of disorders in the very early stage of the disease.

On healthy individuals, there is an increase in the concentration of serum ketoacids about 10 minutes after taking ketovital. The concentration of these ketoacids is 5 times higher than the beginning. The peak concentration reaches about 20–60 minutes and the normal concentration returns after about 90 minutes. The absorption through the gastrointestinal tract is therefore very fast.

The simultaneous increase in the concentration of ketoacid and the corresponding amine acids in the serum indicates that the metabolic speed of ketoacid is very fast. According to the natural transformation path of ketoacids in the body, the Ketoacid provides external supply quickly involved in metabolic processes. Ketoacids follow the transformation path like other amine.

There is currently no specific research on the elimination of ketoacids.

Before taking Ketovital Gia Nguyen medicine prevents and treats chronic renal failure (10 blisters x 10 tablets)

How to use

oral medication. Using drugs with food increases the ability to absorb and metabolize amine acids in the drug ingredient.

Do not chew the tablet.

Medication time: Ketovital tablets can be used for a long time if the glomerular filtration level (GFR) is below 25 ml/minute. At the same time, the amount of protein in the daily diet must be limited below 40 g (for adults).

Dosage

If there is no other indication: use 3 times a day, 4 - 8 tablets each time. Drink right before meals, this dose is used for adults (weighing about 70 kg).

There is no research document about using this drug for children.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Handling: Stop the medication and notify the doctor if there is any harmful reaction when taking overdose.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Ketovital, you may experience unwanted effects (ADR).

Very rare, ADR

Hypercalcemia.

Instructions on how to handle ADR

Need to reduce the amount of vitamin D provided if the phenomenon of hypercalcemia occurs. If the blood calcium level is still increasing, the ketovital dose is needed as well as the drugs with calcium ingredients.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Ketovital drug contraindicated in the following cases:

Patients with hypersensitivity to any ingredients of the drug.

Patients with hypercalcemia.

Patients with amine acid metabolism disorders.

Be cautious when using

Need to regularly monitor the calcium level in serum. Ensure adequate supply of calories.

There is no data on this medication for pediatric patients. Be careful when using drugs for patients with metabolic disorders (phenylketonutia) inherited because in the composition of the drug has phenylalanine.

Pay attention to monitor the phosphate concentration in serum if the drug is used simultaneously with aluminum hydroxyde.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

There is no clinical data on the use of ketovital in pregnant women.

Breastfeeding period

There is no clinical data on the use of ketovital in nursing women.

Drug interaction

Treatment along with other calcium -containing drugs can lead to increased pathology or increased serum calcium concentration. The drugs that make compounds are difficult to soluble with calcium (such as tetracycline, quinolone such as ciprocloxacin and norfloxacin as well as iron, flour) should not be used at the same time as Ketovital to avoid affecting the absorption of active ingredients. The time to use Ketovital and these drugs should be at least 2 hours apart.

If using Ketovital, increased blood calcium concentration, sensitivity to glycosides that act on the heart and even the risk of arrhythmia can also increase.

Because Ketovital has the effect of improving the clinical condition of urea, the treatment if there is a hydroxide aluminum is reduced. Pay attention to reducing serum phosphate levels.

Storage

Store in a dry place, avoid light, temperature below 30 ° C.

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