Kidpredni 5mg effervescent tablets anti -inflammatory, anti -allergic and immunosuppressive (5 blisters x 10 tablets)

Dosage form Box of 5 blisters x 10 tablets
Specifications Prednisolone

Ingredient

Composition information	Content
Prednisolone	5mg

Uses

Indications

Kidpredni drugs are indicated in the following cases:

rheumatoid arthritis, body lupus, some vascular inflammation; Pacific artery and inflammation around the artery, sarcoid disease, bronchial asthma, ulcerative colitis, hemolytic anemia, granulocytosis, and severe allergens including anaphylaxis.

Prednisolon is a glucocorticoid that has anti -inflammatory, anti -allergic and immunosuppressive effects. Prednisolon only has weak mineralocorticoid effects, so if you take the drug in a short time, there is very little risk of keeping Na+ and edema.

Anti -inflammatory effects of Prednisolon compared to other glucocorticoids: 5mg Prednisolon is valid equal to 4mg of methyl prednisolon and equal to 20mg of hydrocortison.

Glucocorticoid uses systemic sugars to reduce the number of lymphocytes, eosin blood cells, mononuclear leukocytes in peripheral blood and reduce their movement into inflamed areas. Glucocorticoid also inhibits the function of lymphocytes and tissue macrophages; Reducing prostaglandin synthesis due to phospholipase inhibition A. glucocorticoid reduces capillary permeability due to inhibition of kinin activity, bacterial internal toxins and reduces the amount of hydrophilic abolishes by base leukemia.

With low doses, glucocorticoids have anti -inflammatory effects, with high doses of glucocorticoids have immunosuppressive effects. Large doses of drugs may reduce antibodies, and the average dose does not have this effect. In some cases, glucocorticoids kill lymphocytes T. Normal cells in peripheral blood are highly resistant to glucocorticoid cell death. However, unusual lymphocytes, including some cancer cells, may be much more sensitive.

Glucocorticoid high doses causes cell death under the program (apoptosis). These anti -lymphocytes are used in chemotherapy in acute lymphocytes and lymphoma.

pharmacokinetic

bio -bio -bio -bio -bio -bio -bio -bio -bio -bio -bio -bio -bio -bio -bio -bio -bio -bio -bio -bio -bio -bio -bio -bio -biochon. Plasma peak concentration reaches 1-2 hours after taking the drug.

Prednisolon binds to protein about 90 - 95%. The clearance of Prednisolon is 8.7 ± 1.6 ml/min/kg. The distribution of the drug is 1.5 ± 0.2 liters/kg.

Prednisolon is metabolized in the liver and metabolites are the form of sulfate and glucuronide ester excreted into the urine. The half -life of Prednisolon is approximately 1.7 - 2.7 hours.

Before taking Kidpredni 5mg effervescent tablets anti -inflammatory, anti -allergic and immunosuppressive (5 blisters x 10 tablets)

How to use

Kidpredni drugs are used orally. Dissolve the pill in a sufficient amount of drinking water (about 20 - 30 ml). Do not use milk, tea, coffee or carbonated drinks, alcohol or calcium to make medicine.

Dosage

Initial: Adults can be from 5 to 60 mg/day, depending on the disease needed to be treated and usually divided into 2-4 times daily. Children can be from 0.14 - 2 mg/kg/day or 4 - 60 mg/m2/day, divided into 4 times.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

In these cases, it is necessary to consider to make the right decision to suspend or stop using Glucocorticoid.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using Kidpredni, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Central nervous system: insomnia, nervousness is easily agitated.

digestion: Increase appetite, indigestion.

Skin: him.

Endocrine and metabolism: diabetes.

Neurological - muscle and bone: joint pain.

eyes: cataracts, glaucom.

Respiratory: Nosebleeds.

Uncommon, 1/1000

Central nerve: dizziness, convulsions, mental disorders, fake brain, headache, mood change, delirium, hallucinations, refreshment.

Cardiovascular: edema, hypertension.

skin: acne, skin atrophy, bruising, hyperpigmentation.

Endocrine and metabolism: Cushing syndrome, Online inhibition of Yen - adrenal, slow growth, glucose intolerance, potassium -reducing, alkaline infection, amenorrhea, sodium and water, hyperlem of blood glucose.

digestive: gastric ulcer - duodenum, nausea, vomiting, bloating, esophageal ulcer, pancreatitis. nervous - muscle and bone: muscle weakness, osteoporosis, fracture.

Instructions on how to handle ADR

In acute indications, except leukemia and anaphylaxis, glucocorticoids should be used in the lowest doses and in the shortest time of clinical effect.

After a long -term treatment with glucocorticoid, there is a possibility of inhibiting the hypothalamus - pituitary - adrenal gland, so it is imperative to reduce the dose of glucocorticoids step by step, instead of sudden stop. Prednisolon's dose reduction process may be applied: every 3 to 7 days decrease 2.5 - 5 mg, until the physiological dose of Prednisolon is approximately 5 mg. If the disease worsens when decreased, increases the dose of prednisolon and then reduces the dose of prednisolon slowly.

Use a single dose of the day that causes less side effects than using doses of division of the day, and the special therapy is a good measure to minimize the inhibition of the adrenal glands and minimize other side effects. In Japanese therapy, every two days of using a single dose, in the morning.

Monitor and periodically evaluate the parameters of osteoporosis, hemorrhage, glucose tolerance, face effects and blood pressure.

Preventive gastric and duodenal ulcerative prophylaxis with antihistamine or proton pump inhibitors when taking high doses of corticosteroids.

All long -term patients with glucocorticoids need additional calcitonin, calcitriol and additional calcium to prevent osteoporosis.

Those who are likely to be immunosuppressive due to glucocorticoid should be warned about the possibility of infection. Notify the doctor the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Kidpredni drugs contraindicated in the following cases:

Severe infections, except for bacterial shock and meningitis.

Knowing hypersensitivity to Prednisolon.

Skin infections of viral, fungi or tuberculosis.

is using a living virus vaccine.

Precautions when using

Use carefully in people with osteoporosis, newly connected people (intestines, blood vessels), mental disorders, stomach ulcers, duodenum ulcers, diabetes, hypertension, heart failure and growing children. Due to the risk of unwanted effects, caution must be used with all body corticosteroids for the elderly, with the lowest doses and in the shortest possible time. Acute adrenal insufficiency may occur when the drug is stopped suddenly after a long time of treatment or when stressed. When using high doses, it may affect the effects of vaccinations.

The ability to drive and operate machinery

There has been no report on the effect of drugs when used for drivers and machinery operation.

Pregnancy

Using whole body corticosteroids for a long time for mothers can lead to newborn weight loss. Using high doses of corticosteroids in the body of the mother may cause a small risk of adrenal hygiene in newborns. In general, using corticosteroids in pregnant women requires consideration of benefits that can be achieved compared to the risks that may occur with mother and child. Corticosteroids need to be used for pregnant women with asthma because asthma is dangerous to cause an oxygen deficiency for the fetus. Using glucocorticoid before premature birth also promotes maturity of the child's lungs, preventing respiratory decline syndrome.

Breastfeeding period

Prednisolon secretes breast milk with less than 1% dose and may not be clinically significant. Be careful when using Prednisolon for breastfeeding.

Drug interactions

prednisolon is a cytochrom p enzyme induction, and is the substrate of the cytochrom CYP 3A enzyme, so this drug affects the metabolism of ciclosporin, erythromycin, phenobarbital, phenytoin, carbamazepin, ketoconzol, ketoconon, ketoconon Rifampicin. Phenytoin, phenobarbital, rifampicin and diuretics decreased potassium can reduce the effect of prednisolon.

Prednisolon can cause hyperlem of blood glucose, so it is necessary to use higher insulin doses.

Avoid simultaneous use of prednisolon with nonsteroidal anti -inflammatory drugs as it can cause stomach ulcers.

Storage

Store drugs in a dry place, avoid light, temperatures below 30 ° C.

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