Kidsolon 4 USP effervescent tablets anti -inflammatory, anti -allergic, immunosuppressive (5 blisters x 10 tablets)

Dosage form Box of 5 blisters x 10 tablets
Specifications Methylprednisolone

Ingredient

Composition information	Content
Methylprednisolone	4mg

Uses

indications

Kidsolon 4 mg drug is indicated in the following cases:

Treatment of rheumatoid arthritis, systemic lupus system. Like acute Leukemia disease, lymphoma, breast cancer and prostate cancer.

Pharmacology

Methylprednisolon is a glucocorticoid, derivative 6 - Alpha - Methyl of Prednisolon, has anti -inflammatory, anti -allergic and immune -inhibiting effects.

Due to methylation Prednisolon, the effect of corticosteroids metabolizes salt has been excluded, so there is very little risk of keeping Na+, and causing edema. The anti -inflammatory effect of methylprednisolon increases by 20% compared to the effect of Prednisolon; 4 mg methylprednisolon is valid as 20 mg of hydrocortison.

Inflammation, any disease is characterized by the escape and absorbent of the white blood cells into the tissue (position) of inflammation. Glucocorticoids inhibit these phenomena.

Glucocorticoid also inhibits the function of lymphocytes and tissue macrophages. Their response ability with antigens and cockroaches is reduced.

In addition to the effect of Glucocorticoid silver function, it also affects the inflammatory reaction by reducing prostaglandin synthesis due to phospholipase activation A.

Glucocorticoid reduces capillary base due to inhibiting the activity of kinine and bacterial internal toxins and reduces the amount of histamine released by base leukemia.

The immunosuppressive effect of glucocorticoid is largely due to the above effects. Large doses of drugs can reduce antibodies, and the average dose does not have this effect (for example: 16 mg/day methylprednisolon).

Glucocorticoid is widely used in the treatment of many different diseases and is a main therapy in the treatment of more severe diseases such as systemic erythematosus lupus and many inflammatory disorders such as cylinders around artery, WGGER, and giant cell artery. For these severe disorders, Glucocorticoid dose begins to reduce the disease quickly and to minimize tissue lesions, then the reinforcement stage with a single dose every day, and gradually reduce to the minimum dosage to work.

In rheumatoid arthritis, the dose starts relatively low. During the acute phase, it may be higher than the dose, then gradually decrease quickly. It is possible to treat people with the main symptoms of the disease in one or a few joints by injecting corticosteroids in the joints.

Dynamic pharmacokinetics

bioavailability is approximately 80%. Plasma concentration reaches a maximum of 1-2 hours after taking the drug. Biological effect time (inhibiting pituitary gland) is about 112 days, can be considered a short effect. Methylprednisolon is metabolized in the liver, like metabolism of hydrocortison, and metabolites are excreted through urine. Half life is approximately 3 hours.

Before taking Kidsolon 4 USP effervescent tablets anti -inflammatory, anti -allergic, immunosuppressive (5 blisters x 10 tablets)

How to use

Kidsolon 4 mg is a oral medication.

Dosage

The starting dose

6 - 40 mg methylprednisolon per day.

The necessary dose to maintain the desired treatment effect is lower than the dose needed to achieve the initial effect, and must determine the lowest dose that can be achieved by the effect of gradually reducing the dose step by step until the signs or symptoms increase.

When you need to take large doses for a long time, apply medication therapy the day after control of the process of the disease, it will be less ADR because there is a recovery time between each dose. In a daily therapy, use a single dose of methylprednisolon every 2 days, in the morning in the span of natural secretion glucocorticoid.

Acute asthma attack

methylprednisolon 38 to 48 mg daily, for 5 days, then additional treatment can be added at lower doses in a week. When from acute attacks, methylprednisolon is gradually reduced.

Severe diseases (see the section of pharmacological properties, the mechanism of action)

At first, Methylprednisolon usually used 0.8 mg/kg/day divided into small doses, then reinforced treatment for a single daily dose, followed by a minimum decrease to the minimum dose.

rheumatoid arthritis

The starting dose is 4 to 6 mg of methylprednisolon per day. During the acute phase, higher doses: 16 to 32 mg/day, then gradually decreases.

Chronic ulcerative ulcerative

Mild illness: Execute feature: Take (8 to 24 mg/day).

Nephropathy syndrome

Start, use daily methylprednisolon doses of 0.8 to 1.6 mg/kg for 6 weeks, then gradually reduce the dose for 6 to 8 weeks.

Sarcoid disease

methylprednisolon 0.8 mg/kg/day, to improve the disease. Low maintenance dose: 8 mg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? When using too high doses for a long time, increase adrenal gland energy and inhibit the adrenal glands may occur.

In these cases, it is necessary to consider to make the right decision to suspend or stop using Glucocorticoid.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not use double the prescribed dose.

Side Effects

When using Kidsolon 4 mg, you may experience unwanted effects (ADR).

The most common effects occur most when using methylprednisolon is high and long -term. Methylprednisolon inhibits prostaglandin synthesis and thus losing the effect of prostaglandin on the digestive tract, including inhibiting gastric acid secretion and protecting the stomach lining. Many ADRs are related to this effect of glucocorticoid.

Common, ADR> 1/100

Central nervous system: Insomnia, nerves are easily agitated.

Digestive: Increase appetite, indigestion.

Skin: him.

endocrine and metabolism: diabetes.

Neurosurgery and bone: joint pain.

Eyes: cataract, glaucoma.

Respiratory: Nosebleeds.

Central nervous system: dizziness, convulsions, mental disorders, fake tumors in the brain, headache, mood change, delirium, hallucinations, refreshment.

Cardiovascular: edema, hypertension.

Skin: acne, skin atrophy, bruising, tissue hyperpigmentation.

Endocrine and metabolism: Cushing syndrome, Online inhibition of Yen - adrenal, slow growth, glucose intolerance, hypotension, alkaline infection, amenorrhea, sodium and water, hyperlem of blood glucose.

digestive: stomach ulcers, nausea, vomiting, bloating, esophageal ulcer, pancreatitis.

Neurology - muscle and bone: weak muscle, osteoporosis, fracture.

Other: Hypersensitivity reaction.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Kidsolon 4 mg drug is contraindicated in the following cases:

Severe infections, except for bacterial shock and meningitis.

Damage caused by viral, mushroom, tuberculosis, using live vaccine.

Caution when using

Patients with osteoporosis, new blood vessels, mental disorders, stomach ulcers, duodenal ulcers, diabetes, hypertension, heart failure and growing children.

Be careful to use corticosteroids for the elderly, with the lowest doses and in the shortest possible time.

Acute adrenal insufficiency may occur when the drug is stopped suddenly after a long time of treatment or when there is stress. When using high doses, it may affect the effects of vaccine vaccinations.

Medicines that lower blood potassium should be cautious when used for patients who are using digitalis preparations and pay attention when combined with other drugs that also cause blood potassium.

The ability to drive and operate machinery

There has been no report on the effect of drugs when used for drivers and operating machinery.

Pregnancy

For extension of body corticosteroids for mothers can lead to mitigation of the babies of newborns. In general, using corticosteroids in pregnant women requires consideration of benefits that can be achieved compared to the risks that may occur with mother and child.

breastfeeding period

Non -contraindication corticosteroids for nursing mothers.

Drug interaction

methylprednisolon is a Cytochrom P450 enzyme induction, and is the substrate of the P450 3A enzyme, so this drug affects the metabolism of ciclosporin, erythromycin, phenobarbital, phenytoin, carbamazepin, ketoconol, rifampicin. Phenytoin, phenobarbital, rifampin and diuretics decreased blood potassium can reduce the effectiveness of methylprednisolon. Methylprednisolon can cause hyperlem of blood glucose, so the higher insulin dose is required.

Storage

less than 30 ° C, dry place, avoid light.

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