Kipel 10 mega We Care tablets and treatment of chronic bronchial asthma, bronchospasm (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Montelukast

Ingredient

Composition information	Content
Montelukast	10mg

Uses

indications

Kipel 10 drugs are indicated in the following cases:

Bronchial asthma: Prevention and treatment of chronic bronchial asthma.

Bronchospasm due to exertion: Preventing bronchospasm.

allergic rhinitis: Treatment of allergic rhinitis (seasonal allergic rhinitis and allergic rhinitis year -round).

Pharmacology

Montelukast causes Cysteinyl Leukotriene receptor receptor in gas pathway thanks to the ability to inhibit bronchospasm due to inhalation of LTD4 in asthma. With a lower doses of 5 mg, significantly inhibits Ltd4, which causes trachea.

Pharmacokinetics

absorption

Montelukast is quickly absorbed after drinking. In adults, after taking 10 mg film tablets at an empty stomach, the average peak concentration in plasma (CMAX) is achieved within 3-4 hours (TMAX). The average oral bioavailability is 64%. Oral and cmax is not affected by standard breakfast.

In children from 2 to 5 years old, using a 4 mg chewing tablet, the average cmax is achieved within 2 hours after chewing.

In adults using a 5 mg chewing tablet at hunger, the average cmax is achieved within 2 - 2.5 hours after chewing. The average oral bioavailability is 73% and 63% when used with standard breakfast.

Distribution

over 99% Montelukast is connected to plasma proteins. Distribution voltage in an average stable state from 8 - 11 liters.

Metabolism

Montelukast is widely metabolized. In adults and children taking treatment dose, the concentration of metabolic substances of Montelukast in plasma in stable state cannot be detected.

Elimination

Montelukast clearance in plasma is 45 ml/minute in healthy adults. After taking Montelukast with radioactive marking, 86% of radioactive activity is found in the fertilizer collected for 5 days and less than 0.2% found in the urine.

Combined with Montelukast's oral bioavail assessment shows Montelukast and its metabolites are excreted mainly through biliary tract.

Some studies show that Montelukast's average plasma sale time in healthy young people ranges from 2.7 to 5.5 hours. Montelukast's dynamic pharmacokinetics are almost linear with oral doses of up to 50 mg. When using 10 mg/day, only a small amount of drugs accumulated in plasma (14%).

Before taking Kipel 10 mega We Care tablets and treatment of chronic bronchial asthma, bronchospasm (3 blisters x 10 tablets)

How to use

Drink whole with water.

Dosage

chronic bronchial asthma

Montelukast should be used once a day in the evening. With the following dose:

Adults and teenagers aged 15 and older: 1 tablet 10 mg.

Children under 15 years of age: Should use the form of preparation and other content more appropriate (using 4 mg chewing tablets in children 2-5 years old and 5 mg chewing tablets in children 6 - 14 years old).

Bronchospasm of exertion (EIB) in patients aged 15 and over

To prevent bronchospasm due to exertion (EIB), the 10 mg of Montelukast single dose should be used at least 2 hours before training.

Using only 1 dosage within 24 hours. If you have used Montelukast every day for other indications (including chronic bronchial asthma), there is no additional dose to prevent EIB.

Allergic rhinitis

For allergic rhinitis, Montelukast should be used once a day. The effect has been shown for seasonal allergic rhinitis when using Montelukast in the morning or evening without having to relate to the time of meals. Time to use drugs depending on the needs of each object.

Adults and teenagers aged 15 and older: 1 tablet 10 mg.

Bronchial asthma and allergic rhinitis

Patients with both bronchial asthma and allergic rhinitis should take 1 tablet daily in the evening.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

The most common reactions that occur are similar to Montelukast's safety properties including abdominal pain, drowsiness, thirst, headache, vomiting and agitation.

Unknown Montelukast can be separated through the peritoneal or dialysis.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not use double the prescribed dose.

Side Effects

When using Kipel 10, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Mental: headache, dizziness.

Systemic: weakness, fatigue.

Respiratory: influenza, sore throat, stuffy nose.

digestive: indigestion, gastritis - bowel.

Metabolic: Increase ALT, increase AST.

Urinary: Pus urine.

Not determined frequency

Hematopoietic and lymphatic system: tends to increase bleeding.

The immune system: Hypersensitivity reaction includes: Anaphylaxis, very rarely getting Eosin leukemia in the liver.

Psychiatric: agitation includes aggressive attitude or opposition, or anxiety, depression, abnormal dreams, hallucinations, insomnia, irritation, hyperactivity, sleepwalking, thinking and acts of suicide (including suicide), tremor.

Nervous system: drowsiness, paresthesia/decrease feeling, convulsions.

Heart disorders: Brushing the chest.

Respiratory, chest and mediastinum disorders: Nose bleeding.

digestive: diarrhea, indigestion, nausea, very rarely suffer from pancreatitis, vomiting.

Hepatitis: rare cholestatic hepatitis, liver cell damage, and many liver damage have been reported in patients treated with Montelukast.

Most of these side effects occur when combined with other disturbing agents such as simultaneous use with other drugs, or using Montelukast in patients at risk of liver disease such as alcoholic or other hepatitis.

Skin and subcutaneous tissue: Evana, bruising, erythema, itching, urticaria.

Muscle and connective tissue: joint pain, muscle pain including cramps.

Systemic and medical condition: edema.

Instructions on how to handle ADR

Notice immediately to the doctor or pharmacist about unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Kipel 10 contraindications in the following cases:

Patients with hypersensitivity to any ingredients of the drug.

Caution when using

General recommendations

Do not use Montelukast in the treatment of bronchospasm during acute asthma attacks, including asthma. Patients should be instructed to use the appropriate treatment. Can continue to use Montelukast during severe asthma attacks.

Patients with severe asthma due to exertion need to have inhaled Agonist (Agonist) inhalation, short effects to save.

may have to reduce inhaled corticosteroids gradually under the supervision of a physician, but not to suddenly replace inhaled corticosteroids or drink with Montelukast.

In patients with aspirin sensitivity, aspirin should not be taken or other nonsteroidal anti -inflammatory drugs while taking Montelukast. Although Montelukast has the effect of improving the respiratory function in patients with asthma sensitive to aspirin, it has not yet been shown to be removed from the bronchospasm caused by aspirin and other nonsteroidal anti -inflammatory drugs in Aspirin sensitive asthma patients.

Mental - Mental effects

There have been reports on neurological and mental disorders in patients who take Montelukast, including adults, teenagers and children. Symptoms have been reported including agitation, aggressive or hostile attitudes, anxiety, depression, abnormal dreams, hallucinations, insomnia, irritation, hyperactivity, sleepwalking, thoughts and actions that want to suicide (including suicide) and tremor.

Doctors and patients need to be vigilant about mental - mental disorders that can occur. It is necessary to guide the patient to notify the doctor if they experience these symptoms. Doctors should carefully assess the risk and benefits of continuing to appoint Montelukast when the symptoms occur.

Eosin eosinophilia

Some rare cases of patients with bronchial asthma treated with Montelukast may have eosin cells that prefer eosin body, sometimes symptoms of vascular inflammation of Churg - Strauss syndrome when reduced corticosteroid dose using systemic sugar.

Preparations containing lactose, not used in patients with rare genetic problems in tolerance of galactose, lactase deficiency or glucose - galactose absorption disorders.

The ability to drive and operate machinery

Be cautious when driving because the drug can cause headaches, dizziness, fatigue, insomnia, hallucinations.

Pregnancy

There is no adequate and well -controlled research on pregnant women. Montelukast is only used for pregnant women when really necessary.

The period of breastfeeding

It is unclear Montelukast's excretion through breast milk. Caution should be careful when taking the drug during breastfeeding.

Drug interaction

No need to adjust the dose when using Montelukast simultaneously with theophyllin, prednison, prednisolon, oral contraceptive, terfenadin, digoxin, warfarin, thyroid hormone, pills, non -steroid anti -inflammatory drugs, Benzodiaz - EPIN, EPIN, EPIn, and EMZIM UNIVERSITY Cytochrom P450 (CYP).

Storage

temperature below 30 ° C, cool dry place. Avoid light and avoid moisture.

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