Klavunamox 625mg Atabay medicine for respiratory infections, skin and soft tissue (3 blisters x 5 tablets)

Dosage form Box of 3 blisters x 5 tablets
Specifications Amoxicillin, clavulanic acid

Ingredient

Composition information	Content
Amoxicillin	500mg
Clavulanic Acid	125mg

Uses

indications

Klavunamox drug is indicated for use of infection treatment caused by sensitive strains in the following specific cases:

Infection of the respiratory apparatus:

Upper respiratory tract infections: Sinusitis , tonsillitis, otitis media, other infections in the ear - nose - throat. Infection of wounds, infections in the abdomen.

Urinary tract infections - genital: cystitis, nephritis - pyelonephritis, urethritis, pelvic infections, syphilis, gonorrhea.

Other bacterial infections: osteomyelitis.

Pharmacology

Amoxicillin is a semi-synthetic antibiotic of β-lactam group with wide bactericidal spectrum for many gram-positive and gram-negative bacteria due to synthetic inhibition of bacterial cells. Amoxicillin is easily destroyed by β-lactamase, so it does not work for bacterial strains producing these enzymes (multiple strains of Entobacteriaceae and Haemophilus Influenaza).

Clavulanic acid due to the fermentation of Streptomyces Clavuligerus, with β-lactam structure is similar to penicillin, capable of inhibiting β-lactamase due to the majority of gram-negative bacteria and staphylococcus. Especially, it has a strong inhibition effect of β-lactamase transmitted via plasmid that resists penicillin and cephalosporin.

Pseudomonas Aeruginosa, Proteus Morganii and Rettgeri, some Entobacter and providentia anti -drugs, both anti -methicilin staphylococcus also. Clavulanic acid itself has very weak antibacterial effects.

Clavulanic acid helps amoxicillin not be destroyed by β-lactamase, and expand the antibacterial spectrum of amoxicillin effectively to many common bacteria that have resisted amoxicillin, resistant penicillins and other cephalosporins.

It is possible to see Amoxicillin and Clavulanate as an antibacterial poison for pneumococcus, streptococcus beta beta, Staphylococcus (sensitive strain with penicillin is not affected by penicillinase), Haemophilus Influenaza and Branhamella Catatrhalis including strong products. β-Lactamase. In short, the bactericidal spectrum of the drug includes:

bacteria strain Viridians, Staphylococcus aureus, Corynebacterium, Bacillus anthracis, Listeria monocytogenes.

Anaerobic: Clostridium, peptococcus, peptostreptoccus.

gramy Aerobic: Haemophilus Influenza, Escherichia Coli, Proteus Mirabilis, Proteus vulgaris, Klebsiella, Samonella, Shigella, Bordetella, Neisseria Gonorrhoeae, Neisseria Meningitides, Vibrio C Holerae, Pasteurella Muitocida.

Anaerobic: Bacteroides including B.fragilis.

The concentration of these 2 substances in the serum is maximum after 1-2 hours of taking the drug. With a dose of 250 mg (or 500 mg), there will be 5 mcg/ml (or 8 - 9 mcg/ml) amoxicillin and about 3 mcg/ml clavulanate in serum. After 1 hour of taking medicine 20 mg/kg amoxicillin + 5 mg/kg Clavulanic acid, there will be an average of 8.7 mcg/ml of amoxicillin and 3.0 mcg/ml of clavulanic acid in serum. The absorption of the drug is not affected by food and it is best to take it right before eating. The oral bioavailability of amoxicillin is 90% and of Clavulanic acid is 75%. The half -life of amoxicillin in serum is 1-2 hours and of clavulanic acid is about 1 hour.

50 - 70% amoxicillin and 30-40% clavulanic acid are discharged through urine in the form of activity. Probenecid extends Amoxicillin's elimination time but does not affect the elimination of clavulanic acid.

Before taking Klavunamox 625mg Atabay medicine for respiratory infections, skin and soft tissue (3 blisters x 5 tablets)

How to use

Klavunamox 625 mg oral.

Dosage

Adults and children over 40 kg

If the physician has no other opinion in treatment, then take 1 tablet Klavunamox 625 mg, use 3 times a day. Good drugs absorb through the gastrointestinal tract, can be taken during or outside meals.

Children under 40 kg

20 mg/5 mg/kg/day - 60 mg/15 mg/kg/day, divided into 3 times. And use as directed by the doctor.

Children 6 years old and under

Should use klavunamox in the form of oral fluid.

Note

The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? However, in general, the acute reactions occur depending on the hypersensitivity of each individual. The risk is definitely increased by potassium when taking the dose is very high because clavulanate acid is used in the form of potassium salt. Can use the method of hemolysis so that the drug is from circulation.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting a dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Klavunamox 625 mg , you may experience unwanted effects (ADR).

Harmful reaction

Klavunamox 625 mg well tolerated. The common harmful effects are diarrhea, nausea, rash, urticaria, vomiting, vaginitis. The general incidence of harmful reactions, especially diarrhea, usually increases when high doses recommended.

Other reactions, less common

abdominal discomfort, flatulence, headache . And

Hypersensitivity reaction

Includes rashes, itching, urticaria, diverse roses. These reactions can be controlled with H1 antihistamines and when needed, use corticosteroids systemic. At any time, the above reactions must be stopped, unless other physicians have other opinions. Rarely hyperactive, agitation, anxiety, insomnia, confusion, and/or dizziness.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug klavunamox 625 mg , you need to read the instructions carefully and consult the information below.

Contraindicated

Klavunamox 625 mg drug is contraindicated in cases where a history of allergic reactions to the penicillin group.

Be cautious when using

occasionally encounter serious anti -fatal (hypersensitivity) in patients using penicillin. These reactions are more common in people with a history of hypersensitivity to penicillin and/or a history of hypersensitivity to many different antigens. It also met a person with a hypersensitivity to penicillin and was seriously crossed when using cephalosporin. Therefore, before the beginning of using Klavunamox 625 mg, careful investigation to see if the patient had previously had hypersensitivity reactions to penicillin, cephalosporin or other antigens.

When all allergic reactions, stop the drug immediately and take appropriate treatment. If there are serious anaphylaxis reactions, emergency treatment must be immediately treated with epinephrine. Sometimes it is necessary to indicate oxygen, intravenous corticosteroid and airway ventilation.

Although penicillin is very low toxicity, it is still necessary to evaluate the function of the organs, such as kidneys, liver, hematopoietic function when used for a long time. There has been a high percentage of patients with mononuclear hypercasses and using ampicillin will be rash on the skin. Therefore, do not use ampicillin group antibiotics for patients with single leukemia.

During the treatment with Klavunamox 625 mg, it is necessary to remember the ability to be superinfected with bacterial or fungi sprouts. If the superinfection is encountered (usually Pseudomonas or Candida), it is necessary to stop the drug and take appropriate treatment.

The ability to drive and operate machinery

drugs hardly affect the ability to drive and operate machinery.

During pregnancy and lactation

pregnancy

There is no clear evidence of the safety of Klavunamox 625 mg during pregnancy. Therefore, only this medication for pregnant people is really necessary.

Breastfeeding period

Penicillin antibiotics are sold in milk, need to be cautious when using Klavunamox 625 mg for nursing mothers.

Drug interaction

Probenecid reduces amoxicillin elimination through the renal tubules, so when combined with probenecid, the content of amoxicillin in the blood can increase and prolong. Combining Allopurinol with ampicillin increases the rash compared to when using Ampicillin alone. It is unclear whether allopurinol increases the rash due to ampicillin or the patient has hyperuric/blood hyperkemis. There is no data on Allopurinol combination with klavunamox 625 mg.

The drug can cause prolonged bleeding and coagulation time. Therefore, it is necessary to be careful for those who are treated with anticoagulants.

Oral Klavunamox 625 mg increases high concentration amoxicillin in urine, thereby leading to a fake positive reaction when testing glucose in the urine. Therefore, it is necessary to test the ureter glucose test according to the glucose-oidase enzyme reaction when the patient uses Klavunamox 625 mg.

Like antibiotics with broad effects, the drug can reduce the effectiveness of oral contraceptives, so it is necessary to notify the patient in advance.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

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