Klavunamox oral powder 400/57mg Atabay treatment of severe respiratory infections (70ml)

Dosage form Bottle x 70ml
Specifications Amoxicillin, clavulanic acid

Ingredient

Thành phần cho 5ml

Composition information	Content
Amoxicillin	400mg
Clavulanic Acid	57mg

Uses

indications

The drug is indicated in the treatment of bacterial infections caused by sensitive strains in the following specific cases:

Infection of the respiratory apparatus:

Upper respiratory tract infections: sinusitis, tonsillitis, otitis media , other infections in the ear-nose-nose-nose. in the abdomen.

Urinary tract infections - genital: cystitis, nephritis - pyelonephritis, urethritis, pelvic infections, syphilis, gonorrhea.

Other bacterial infections: osteomyelitis.

Pharmacology

Amoxicillin is a semi-synthetic antibiotic belonging to the β-lactam group with wide bactericidal spectrum for many gram-positive and gram-negative bacteria due to the synthetic inhibition of bacterial cell walls. Amoxicillin is easily destroyed by β-lactamase, so it does not work for bacterial strains producing these enzymes (multiple strains of Entobacteriaceae and Haemophilus Influenaza).

Clavulanic acid due to the fermentation of Streptomyces Clavuligerus, with β-lactam structure is similar to penicillin, is capable of inhibiting β-lactamase due to the majority of Gram-negative bacteria and Staphylococcus. Especially, it has a strong inhibition effect of β-lactamase transmitted via plasmid that resists penicillin and cephalosporin.

Pseudomonas Aeruginosa, Proteus Morganii and Rettgeri, some Entobacter and providentia anti -drugs, both anti -methicilin staphylococcus also. Clavulanic acid itself has very weak antibacterial effects.

Clavulanic acid helps amoxicillin not be destroyed by β-lactamase, and expand the antibacterial spectrum of amoxicillin effectively to many common bacteria that have resisted amoxicillin, resistant penicillins and other cephalosporins.

It is possible to see Amoxicillin and Clavulanate as an antibacterial poison for pneumococcus, streptococcus beta beta, Staphylococcus (sensitive strain with penicillin is not affected by penicillinase), Haemophilus Influenaza and Branhamella Catatrhalis including strong products. β-Lactamase. In short, the bactericidal spectrum of the drug includes:

bacteria

strain

aerobic: Streptococcus Faecalis, Streptococcus Pneumonia, Streptococcus Pyogenes, Streptococcus Viridians, Staphylococcus aureus, Corynebacterium, Bacillus anthracis, Listeria monocytogenes.

Anaerobic: Clostridium, peptococcus, peptostreptoccus.

Aerobic: Haemophilus Influenza, Escherichia Coli, Proteus Mirabilis, Proteus vulgaris, Klebsiella, Samonella, Shigella, Bordetella, Neisseria Gonorrhoeae, Neisseria Meningitides, Vibrio C Holerae Muitocida.

Anaerobic: Bacteroides including B.fragilis.

The concentration of these 2 substances in the serum is maximum after 1-2 hours of taking the drug. With a dose of 250 mg (or 500 mg), there will be 5 mcg/ml (or 8 - 9 mcg/ml) amoxicillin and about 3 mcg/ml clavulanate in serum. After 1 hour of taking medicine 20 mg/kg amoxicillin + 5 mg/kg Clavulanic acid, there will be an average of 8.7 mcg/ml of amoxicillin and 3.0 mcg/ml of clavulanic acid in serum. The absorption of the drug is not affected by food and it is best to take it right before eating. The oral bioavailability of amoxicillin is 90% and of Clavulanic acid is 75%. The half -life of amoxicillin in serum is 1-2 hours and of clavulanic acid is about 1 hour.

50 - 70% amoxicillin and 30-40% clavulanic acid are discharged through urine in the form of activity. Probenecid extends Amoxicillin's elimination time but does not affect the elimination of clavulanic acid.

Before taking Klavunamox oral powder 400/57mg Atabay treatment of severe respiratory infections (70ml)

How to use

Shake well before use.

The absorption of Klavunamox 400/57 mg is best when taken right before meals. Treatment time should be suitable for indications and should not exceed 14 days without changing. Add water to fill the mark on the jar, shake strongly to mix the dough.

Dosage

Normal daily dose:

25/3.6 mg/kg of weight/day with mild to medium -sized infection (upper respiratory infections such as recovery tonsillitis, lower respiratory infections and skin and soft tissue infections). Em.

Children older than 2 years old

25/3.6 mg/kg weight/day 2 - 6 years old (13 kg - 21 kg) 5.0 ml of klavunamox 400/57 mg twice daily Klavunamox 400/57 mg twice daily

45/6.4 mg/kg weight/day 2 - 6 years old (13 kg - 21 kg)

10.0 ml of klavunamox 400/57 mg twice daily

kg) 10.0 ml of Klavunamox 400/57 mg twice daily

Children under 2 years of age should take dose by weight.

Note

The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Although using too much klavunamox, the drug still causes less complications, because it is well tolerated even at high doses. However, in general, the acute reactions occur depending on the hypersensitivity of each individual. The risk is definitely increased by potassium when taking the dose is very high because Clavulanate acid is used in the form of potassium salt.

Handling

Can use the method of hemolysis so that the drug is from circulation. In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting a dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using the drug, you may experience unwanted effects (ADR).

Harmful reaction

Klavunamox 400/57 mg well tolerated, the common harmful effects are diarrhea, nausea, rash, urticaria, vomiting, vaginitis. The general incidence of harmful effects, especially diarrhea, usually increases when high doses recommended.

Other, less common reactions, including: abdominal discomfort, flatulence, headache . And

Hypersensitivity reaction

Includes rashes, itching, urticaria, diverse roses. These reactions can be controlled with H1 antihistamines and when needed, use corticosteroids. At any time, the above reactions must be stopped, unless other physicians have other opinions. Rarely hyperactive, agitation, anxiety, insomnia, confusion, and/or dizziness.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Klavunamox drugs contraindicated in cases where a history of allergic reactions to the penicillin group.

Be cautious when using

occasionally encounter serious anti -fatal (hypersensitivity) in patients using penicillin. These reactions are more common in people with a history of hypersensitivity to penicillin and/or a history of hypersensitivity to many different antigens. Also met people with hypersensitivity to penicillin and severely cross -crossed when using cephalosporins.

Therefore, before starting the use of Klavunamox 400/57 mg, careful investigation must be investigated to see the patient previously had hypersensitivity reactions to penicillin, cephalosporin or other antigens.

When all allergic reactions, stop the drug immediately and take appropriate treatment. If there are serious anaphylaxis reactions, emergency treatment must be immediately treated with epinephrine. Sometimes it is necessary to indicate oxygen, intravenous corticosteroid and airway ventilation.

Although penicillin is very low toxicity, it is still necessary to evaluate the function of the organs, such as kidneys, liver, hematopoietic function when long -term use. There has been a high percentage of patients with mononuclear hypercasses and using ampicillin will be rash on the skin. Therefore, do not use ampicillin group antibiotics for patients with single leukemia.

During the treatment with Klavunamox 400/57 mg, it is always necessary to remember the ability to be superinfected with bacterial or fungi sprouts. If the superinfection is encountered (usually Pseudomonas or Candida), it is necessary to stop the drug and take appropriate treatment.

The ability to drive and operate machinery

drugs hardly affect the ability to drive and operate machinery.

During pregnancy and lactation

pregnancy

There is no clear evidence of the safety of Klavunamox 400/57 mg during pregnancy, so only this medication for pregnant women when really necessary.

Breastfeeding period

Penicillin antibiotics are sold in milk. Be careful when using Klavunamox 400/57 mg for nursing mothers.

Drug interaction

Probenecid reduces amoxicillin elimination through the renal tubules, so when combined with probenecid, the content of amoxicillin in the blood can increase and prolong. Combining Allopurinol with ampicillin increases the rash compared to when using Ampicillin alone. It is unclear whether allopurinol increases the rash due to ampicillin or the patient has hyperuric/blood hyperkemis. There is no data on Allopurinol combination with klavunamox 400/57 mg.

The drug can cause prolonged bleeding and coagulation time. Therefore, it is necessary to be careful for those who are treated with anticoagulants.

Like antibiotics with broad effects, the drug can reduce the effectiveness of oral contraceptives, so it is necessary to notify the patient in advance.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

Other drugs

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