Kozeral 10mg Davipharm tablets treat painful to severe after surgery (6 blisters x 10 tablets)

Dosage form Box of 6 blisters x 10 tablets
Specifications Ketorolac tromethamine

Ingredient

Composition information	Content
Ketorolac tromethamine	10mg

Uses

indications

Kozeral medicine is indicated in short -term treatment of pain that has just been severe after surgery. The drug can also be used instead of opioid preparations.

Pharmacological

Ketorolac is a nonsteroidal anti -inflammatory drug with chemical structure similar to indomethacin and tolletin. Ketorolac inhibits prostaglandin biosynthesis. The drug has analgesic, anti -inflammatory, cooling effect but analgesic effect is greater than the anti -inflammatory effect. Unlike opioid drugs, Ketorolac is not addictive or respiratory inhibitors. In addition, Ketorolac also has anti -inflammatory effects when used at the eye.

However, because Ketorolac inhibits prostaglandin synthesis, it also increases the risk of bleeding due to platelet aggregation inhibits and increases the risk of stomach ulcers. Similarly, the synthetic inhibition of kidney prostaglandin can reduce the flow through the kidneys in people with impaired renal function.

Ketorolac is a non -steroid substance that has a strong and moderate anti -inflammatory analgesic effect, is used instead of opioid groups and nonsteroidal painkillers, in the treatment of painful pain after surgery, and can be used in acute muscle pain or other pain and inflammation in the eye.

Dynamic pharmacokinetics

After intramuscular or drinking, Ketorolac absorbs quickly and completely. The absorption rate decreases when taking medicine and a high -fat meal, but the absorption does not decrease. The absorption is not affected when used simultaneously with antacids. The distribution volume is about 0.15 - 0.33 l/kg. Protein bonds are very high (> 99%). Under 50% of the dose is metabolized.

Half lifetime eliminated in adults with normal kidney function is about 5.3 hours and lasts longer in people with renal function (about 10.3 - 10.8 hours or more). A small amount of medicine allocated into breast milk.

Before taking Kozeral 10mg Davipharm tablets treat painful to severe after surgery (6 blisters x 10 tablets)

How to use

Treatment time does not exceed 5 days.

Take medicine during meals or snacks to reduce the stomach irritation, although you can take 2 doses at hunger to work quickly or use with antacids.

Take medicine with a full cup of water and hold in a upright position for 15-30 minutes to reduce the risk of irritation of esophageal irritation.

Dosage

Usual adult dose

Pain relief, follow after initial injection therapy.

Patients 16 - 64 years old, weighing 50 kg, normal kidney function: 20 mg initially, followed by 10 mg to 4 times daily, 4-6 hours apart, if necessary.

Patients

Common doses in the elderly

Pain relief, oral (after injection): 10 mg, until 4 times/day, 4 - 6 hours/1 time. Maximum dose prescribed for the elderly: Take 40 mg/day.

What to do when overdose? Need to monitor patients carefully and treat symptoms.

If kidney failure, you may need to apply blood. However, the unworthy separation has eliminated Ketorolac from the body after overdose. There has been a notice in the patient being separated, reducing the half -life and half -life of Ketorolac.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Kozeral medicine, you may experience unwanted effects (ADR).

Most adverse drug reactions of symptoms in the central nervous system such as headache, dizziness and drowsiness. In addition, some reactions in the gastrointestinal tract are common such as indigestion, nausea, pain and irritation. It should be noted that patients treated with nonsteroidal anti -inflammatory drugs such as ketorolac may have acute renal failure or hyperkalemia or both. Especially cautious in the case of the patient had previously had kidney failure.

Common, ADR> 1/100

Body: edema, headache, dizziness.

Body: weakness, pale. Ban.

Body: Anaphylaxis reaction, including bronchial spasm, laryngeal edema, hypotension, skin rash, pulmonary edema. Mobility.

Notify the physician unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Kozeral medicine 10mg contraindicated in the following cases:

History of stomach ulcers or gastrointestinal bleeding. Local bleeding, coagulation disorders.

Patients with surgery, high risk of bleeding or incomplete bleeding.

Patients are taking anticoagulants. Management. Ketorolac should not be used for this age.

Be cautious when used

do not combine ketorolac with other nonsteroidal anti -inflammatory drugs, with aspirin and corticosteroids.

Be cautious if you feel dizzy or drowsiness, no driving, operating machinery or doing jobs that need to be alert.

When treating patients with reduced renal function, medium or liver failure, especially in the case of simultaneous use with diuretics, it is necessary to consider the risk of water retention and the risk of worse kidney function. Dose reduction for people weighing less than 50 kg.

Be cautious when taking medicine for the elderly because in this patient Ketorolac eliminates more slowly and they are more sensitive to the toxic effects on the kidneys and are harmful in the digestive tract.

The ability to drive and operate machinery

Caution if you feel dizzy or drowsiness, no driving, operating machinery or doing jobs that need to be alert.

pregnancy and lactation

Do not use Kozeral medicine for pregnant women and nursing women.

Drug interaction

Most of the following interactions have not been notified to Ketorolac, but there has been notice for other nonsteroidal anti -inflammatory drugs. Therefore, it is also necessary to consider and be cautious when using ketorolac, especially when taking long -term drugs:

Steroid anti -inflammatory drugs may increase the risk of secondary renal failure in patients who are taking diuretics, due to reduced blood flow through the kidneys. Cong (AUC) total and half -life of ketorolac.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

Other drugs

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