Kremil-S United chewing tablets treat stomach pain, reduce stomach burning, heartburn, heartburn (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Simethicone, magnesium hydroxide, aluminum hydroxyd

Ingredient

Composition information	Content
Simethicone	30mg
Magnesium hydroxide	233mg
Aluminum hydroxyd	178mg

Uses

indications

Kremil-S drugs are indicated in the following cases:

Reduce symptoms such as indigestion, heartburn, flatulence. Simethicone has an anti -foaming effect against flatulence due to the ability to change the surface tension of the vapor bubbles, thus making them combining together.

pharmacokinetics

magnesium hydroxide reacts with hydrochloric acid in the stomach to form magnesium chloride. A small amount of Magnesium salt can be absorbed and excreted in the urine, the rest excreting the stool.

Aluminum hydroxide reacts with hydrochloric acid in the stomach to form aluminum chloride, in which some are absorbed. Aluminum is absorbed in urine.

Most of the remaining aluminin in the digestive tract and forming insoluble aluminum salt include hydroxide, phosphate, carbonate and fatty acid derivatives, excreted in fertilizer.

There is no data on Simethicone's dynamics.

Before taking Kremil-S United chewing tablets treat stomach pain, reduce stomach burning, heartburn, heartburn (10 blisters x 10 tablets)

How to use

Kremil-S should chew the tablet before swallowing, use after each meal for about 1 hour and before going to bed; or when pain.

Dosage

Dosage for adults: take 1-2 capsules after each meal about 1 hour and before going to bed; or when pain with a total dose of no more than 8 capsules a day, or according to the prescription of the doctor.

Not recommended for children.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms of acute overdose due to the combination of aluminum hydroxide and magnesium salt have been reported including diarrhea, abdominal pain, and vomiting.

Large doses can cause or aggravate intestinal obstruction and intestinal paralysis in risks.

Aluminum and Magnesium are eliminated by urinary tract, acute overdose treatment including calcium gluconate intravenous injection, water compensation and strong diuretic use. In the case of kidney function, dialysis or peritoneal dialysis is necessary.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose?

Side Effects

When using Kremil-S gastrointestinal drug, you may experience unwanted effects (ADR).

Unwanted frequency of effects is defined as follows:

Very common (≥ 1/10), common (≥ 1/100 to

immune system disorders

Smart reports: Hypersensitivity reactions such as itching, urticaria, angioedema and anaphylactic reaction.

Uncommon: diarrhea or constipation ..

Discounted reports: abdominal pain.

Very rare: Increasing Magnesium sample, monitoring after using magnesium hydroxide prolonged in patients with renal impairment. Urinary, puree.

Instructions on how to handle ADR:

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Kremil-S contraindications in the following cases:

Hypersensitivity to the active ingredient or any component of the dozen.

Be cautious when using

Aluminum hydroxide can cause constipation and overdose of Magnesium salt, causing reducing bowel motility, large doses that can cause or aggravate intestinal obstruction and intestinal paralysis in high -risk patients such as kidney failure, elderly people.

Aluminum hydroxide is absorbed less from the gastrointestinal tract, rarely facing systemic effects in patients with normal kidney function. However, the dose is too high or prolonged, or even the normal dose in patients with a low diet of phosphorus, which can lead to reducing blood phosphate (due to aluminum associated with phosphate) with an increase in bone cancellation and increased calcium urine with the risk of bone puree. It is necessary to advise a doctor in the case of prolonged medication or in patients at risk of reducing blood phosphate.

Patients with renal failure, concentration of aluminum and magnesium in the blood increased. In these patients, using aluminum and magnesium salt for a long -dose can lead to dementia, small red blood cell anemia.

Use aluminum hydroxide may not be safe in patients with porphyrin metabolic disorders, which are dialysis.

The drug contains a dozen aspartame: Aspartame is a source of phenylalanine. It may be harmful if the patient has urinary phonylceton (PKU), a rare genetic disorder causing phenylalanine accumulation because the body cannot be removed properly.

The ability to drive and operate machinery

There is no relevant information.

Using drugs for women during pregnancy and lactation

There is no data on the safety of Kremil-S for pregnant women.

Due to the restricted mother's absorption, when taking the recommended dose, the Magnesium and Aluminum Hydroxide salt compounds, if any, is excreted in breast milk with the amount of Simethicone darkness not absorbed from the digestive tract.

There is no effect on infant babies who have newborns for breastfeeding because of the exposure of aluminum hydroxide, magnesium hydroxide and simethicone in breastfeeding women are negligible.

Drug interaction

should not be used simultaneously with Kremil-S with other drugs because it can change the absorption of these drugs if used within 1 hour.

Aluminum -containing antacids can hinder the absorption of other drugs such as tetracycline, vitamins, ciprofloxacin, ketoconazole, hydroxychloroquine, chloroquine, chlorpromazine, rifampicin, cefdinir, cefpodoxime, levothyroxine, rosovastatin.

levothyroxin can also be connected to Simethicone slow down or reduce the absorption of Launthurovin.

Polystyrene Sulphonate: Caution should be used simultaneously with Polystyrene Suphonate due to reducing the ability to bind resin in when the risk of metabolic infection in patients with renal insufficiency (reported when using aluminum hydroxide and magnesium hydroxide), and intestinal obstruction (reported when using aluminum hydroxide).

Aluminum hydroxide and citrate may increase aluminum levels, especially in patients with renal impairment.

Urine saving due to Magnesium hydroxide can change the darkness of some drugs, observing the increase in salicylate secretion.

Cavalry of the drug: not applicable.

Storage

Store at a temperature not exceeding 30 ° C.

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