Kupdina hard capsules 100mg Korea United Pharm treat pain in endometriosis, mammary fibroids (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Danazol

Ingredient

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Composition information	Content
Danazol	100mg

Uses

indications

Kupdina drug are indicated in the following cases:

Endometriosis treatment

Pain in endometriosis due to hormonal changes. Danazol is also used to relieve pain when the hormone has chosen not worked, intolerant or contraindicated. Do not use Danazol in cases where surgery is required.

Treatment of mammary fibroids

Danazol has the effect of reducing tumors, pain relief and discomfort caused by mammary fibroids due to changing the hormone content in the body. However, the symptoms may return after stopping the drug.

Treatment of genetic angioedema

Danazol is indicated to prevent diseases caused by genetic angioedema (in the skin, abdomen, laryngeal) in men and women.

Pharmacokic

Danazol is a synthetic derivative of Ethisteron (Ethinyl Testosteron). Danazole prevents the pituitary -ovary transmission by inhibiting the signal of the pituitary gland and Gonadotropin in the hypothalamus. Danazole directly inhibits the synthesis of sex steroids and associated with the receptor of sex steroids in the cytoplasm of diseases and thus shows weak anti -estrogen activity, the ability to assimilate and androgen activity is weak. Androgen activity depends on the dose. Danazol does not affect normal release of corticotrophin from the pituitary or cortisol from the adrenal gland.

When using this drug for women on a number of clinical studies, Danazol prevents the hormone stimulating follicles (ESH) and the hormone to create the coronary (LH) and reduces esteriol and progesterone levels in plasma. Research on men treated Danazol also showed a decrease in plasma concentrations of FSH, LH, testosteron and dihydroepitestosteron.

In the treatment of endometriosis, the blockage of ovarian steroids causes peanut tissue to shrink. No ovulation and amenorrhea can occur in most women after 6-8 weeks of treatment with Danazol. However, when studying on men treated with Danazol, there is no change in sperm count.

Research in patients with genetics treated with Danazol, serum concentration of esterase inhibitor 1 (C1) is 4.5 times and C4 concentration is 15 times higher than the concentration before taking the drug. Research in patients lacking factor VIII (Difficult blood disease A) and patients who lack IX factor (hemorrhagic blood disease B), Danazol significantly increases the concentration of factor VIII and the corresponding IX factor in patients.

Danazol also works to increase Alpha - Antitrysin in patients with this enamel deficiency. And on patients with hemorrhage due to idiopathic platelets Danazol also significantly reduced IgG mounted on platelet surfaces.

pharmacokinetics

After drinking, danazol is absorbed through the gastrointestinal tract and metabolism in the liver. The absorption increases if drinking Danazol with food. Semi -cancellation time in plasma is about 3-6 hours when using a single dose, but increasing to about 26 hours when the dose is repeated.

The main metabolites of Danazol are Ethisteron, 2 - Hydroxymethylisteron and 17 - Hydroxymethylisteron, but these metabolites have no pituitary inhibition activity.

Danazol and metabolites can pass through the liver - intestinal circulation. The metabolites are excreted into urine and feces.

Before taking Kupdina hard capsules 100mg Korea United Pharm treat pain in endometriosis, mammary fibroids (3 blisters x 10 tablets)

How to use

oral medication.

Dosage

Endometriosis

Initial dose: 800 mg/day divided into 2 doses. The treatment should be started on the first day of the menstrual cycle, if not guaranteed the patient is not pregnant at the beginning of treatment with Danazol. The treatment should last continuously from 3 to 6 months or 9 months if needed. After the end of the treatment, if the symptoms re -return, should continue with another treatment.

Mammary gland fibroids

100 mg - 400 mg/day divided into 2 doses depending on the response of the patient. The treatment should be started during menstruation, if not guaranteed the patient is not pregnant at the beginning of treatment with Danazol. In most cases, breast pain and discomfort significantly decreased in the first month and completely ended in the 2nd to the 3rd month. For tumors, it is necessary to treat continuously from 4 to 6 months.

Genesis prevention

The treatment dose depends on the condition of each patient, which should start at a dose of 200 mg, 2 or 3 times daily.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

There is no specific antidote.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not use double the prescribed dose.

Side Effects

When using Kupdina , you may experience unwanted effects (ADR).

Not determined frequency

Malge effect: Acne , edema, mild hair, mammary atrophy, deep voice, increase the greases of the skin and hair, weight gain, rare hypertrophy of clitoris or testicular atrophy.

Unwanted effects due to decrease in estrogen: vaginitis accompanied by itching, dryness, with or without bleeding, redness, sweating, stress, instability.

Liver failure: Due to liver enzyme, and/or jaundice, have been seen in patients using Danazol 400 mg or more daily.

Allergic reactions: Rarely nose congestion, rash.

Central nerve: dizziness, headache, sleep disorders, fatigue, shudder. Rarely mildly paralysis in limbs, changing appetite, and chills.

Gastrointestinal - gastritis: Gastritis - intestines, rarely vomiting, nausea, and constipation.

Bone muscle: Muscle or spasm, joint stiffness, swelling of joints, back pain, neck, or limb.

Urinary genitals: bloody urination.

Unwanted effect on heart rate and blood pressure: Some patients may have an increase in heart rate and hypertension. Benign intracellular turbocharger and visual disorders can occur.

Other undesirable effects: Increasing insulin demand in diabetics, hair loss.

Instructions on how to handle ADR

Notify the doctor the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Kupdina drug contraindicated in the following cases:

Abnormal genital bleeding.

Be cautious when using

periodically monitor liver and kidney function when using Danazol because Danazol can damage these organs. In fact, the liver tumor has been encountered in long -term treatment.

danazol Use cautiously in patients with hypercholesterol due to danazol can reduce HDL, cholesterol transport agent out of the vascular wall and increase LDL with the function of bringing cholesterol to the circuit wall.

Danazol may have a male fetal effect, so avoid for pregnant women, and should use contraceptives that are not related to hormones during treatment.

Do not use Danazol for nursing women. Use cautious in children and adolescents because the drug can cause early puberty in boys, causing masculinity in girls, and early bones in both boys and girls.

should periodically check the quality of semen quality (due to the volume, viscosity, the total number of sperm and the movement of sperm) during the treatment process with Danazol, especially for minors. If there is abnormal, should stop treatment.

Danazol should be used cautiously in patients with cardiovascular disorders, liver dysfunction and kidney function because the disease may be severe due to water stasis; Avoid use in patients with severe functional function.

Use caution in patients with diabetes, patients with red blood cell hyperactivity, lipid disorders, patients with migraine or epilepsy.

Do not use Danazol in patients with sexual bleeding have not been diagnosed, cancer patients dependent Androgen.

Using the same derivatives 17α - Alkyl may increase the risk of liver damage, if used simultaneously, it is necessary to check the liver function during treatment.

Do not use drugs in patients with thrombosis or a history of thrombosis.

Use caonaol caution in patients with porphyrin metabolic disorders.

In the event that the symptoms of androgen effects must be discontinued because the symptoms will not recover if they continue to use the drug.

The ability to drive and operate machinery

Danazol can cause dizziness, headache and fatigue so patients use drugs should not drive or operate machinery.

Pregnancy

Contraindicated drugs for women during pregnancy.

Lactation period

Contraindicated use of drugs for women during breastfeeding.

Drug interaction

carbamazepin: simultaneous use of carbamazepin with Danazol can increase the sale time and reduce carbamazepine clearance, leading to increased carbamazepine levels in plasma.

Cyclosporin: Danazole inhibits metabolic leads to increased cyclosporin levels.

tacrolimus: Danazole inhibits metabolism leads to an increase in the concentration of Tacrolimus immunological inhibitors.

warfarin: Danazol may increase the effects of anticoagulants Warfarin.

Statins: Sharing danazol with statins drugs that can cause muscle globin.

insulin: Patients with diabetes need to increase insulin dose.

Testing: Danazol treatment may affect testosteron, Androstenedion and Dehydroepiandrostrosteron.

Storage

At room temperature no more than 30 ° C.

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