Kupdina hard capsules 200mg Korea United Pharm treat pain in endometriosis, mammary fibroids (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Danazol

Ingredient

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Composition information	Content
Danazol	200mg

Uses

indications

Kupdina 200 mg drug are indicated in the following cases:

Endometriosis

Pain in endometriosis due to hormonal changes. Danazol is also used to relieve pain when the hormone has chosen not worked, intolerant or contraindicated. Do not use Danazol in cases where surgery is required.

Mammary gland fibroids

Danazol works to reduce tumors, relieve pain and reduce discomfort caused by mammary gland fibroids due to changing hormone content in the body. However, the symptoms may return after stopping the drug.

Genesis prevention

Danazol is indicated to prevent the diseases caused by genetic angioedema (in the skin, abdomen, pants) in men and women.

Pharmacokology

Danazol is a synthetic derivative of Ethisteron (Ethinyl Testosteron). Danazol prevents the pituitary-pituitary transmission by inhibiting the signal of the pituitary gland and Gonadotropin in the hypothalamus. Danazole directly inhibits the synthesis of sex steroids and associated with the receptor of sex steroids in the cytoplasm of diseases and thus shows weak anti -estrogen activity, the ability to assimilate and androgen activity is weak. Androgen activity depends on the dose. Danazol does not affect the normal release of corticotrophin from the pituitary or cortisol from the adrenal gland.

When using this drug for women on a number of clinical studies, Danazol prevents follicles stimulating follicles (FSH) and hormones to form the body (LH) and reduce esteriol and progesterone levels in plasma. Research on men treated with Danazol also showed a decrease in plasma concentrations of FSH, LH, testosteron and dihydroepitestosteron.

In the treatment of endometriosis, the blockage of ovarian steroids causes peanut tissue to shrink. No ovulation and amenorrhea can occur in most women after 6-8 weeks of treatment with Danazol. However, when studying on men treated with Danazol, there is no change in sperm count.

Research in patients with genetics treated with Danazol, serum concentration of esterase inhibitor 1 (C1) is 4.5 times and C4 concentration is 15 times higher than the concentration before taking the drug. Research in patients lacking factor VIII (difficulty blood disease A) and patients who lack IX factor (difficulty blood disease B), Danazol significantly increases the concentration of factor VIII and the corresponding IX factor in patients. Danazol also works to increase alpha1-antitrypsin in patients with this enamel deficiency. In patients with hemorrhage due to idiopathic platelets, Danazol also significantly reduces IgG mounted on platelet surfaces.

Dynamic pharmacokinetics

After drinking, Danazol is absorbed through the gastrointestinal tract and metabolism in the liver. The absorption increases if drinking Danazol with food. Selling time in plasma is about 3-6 hours when using a single dose, but increases to about 26 hours when the dose is repeated. The main metabolites of Danazol are Ethisteron, 2-Hydroxymethylisteron and 17- Hydroxymethylisteron, but these metabolites have no pituitary inhibition activity. Danazol and metabolites can pass through the liver and liver circulation. The metabolites are excreted into urine and feces.

Before taking Kupdina hard capsules 200mg Korea United Pharm treat pain in endometriosis, mammary fibroids (3 blisters x 10 tablets)

How to use

oral medication.

Dosage

Endometriosis

Starting dose

800 mg/day is divided into 2 doses. The treatment should be started on the first day of the menstrual cycle, if not guaranteed the patient is not pregnant at the beginning of treatment with Danazol. The treatment should last continuously from 3 to 6 months or 9 months if needed. After the end of the treatment, if the symptoms re -return, should continue with another treatment.

Mammary gland fibroids

100 - 400 mg/day is divided into 2 doses depending on the response of the patient. The treatment should be started during menstruation, if not guaranteed the patient is not pregnant at the beginning of treatment with Danazol. In most cases, breast pain and discomfort significantly decreased in the first month and completely ended in the 2nd to the 3rd month. For tumors, it is necessary to treat continuously from 4 to 6 months.

Vascular angiography prevention

Dose depends on the condition of each patient, which should start at a dose of 200 mg, 2 or 3 times daily.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? There is no specific antidote.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using Kupdina drug , you may experience unwanted effects (ADR):

Effects of menus: Acne, edema, mild hair, mammary atrophy, deep voice, increased oily skin and hair, weight gain, rare hypertrophy of clitoris or testicular atrophy.

Unwanted effect due to decreased amount of estrogen: Vaginitis accompanied by itching, dryness, with or no bleeding, flushing, pouring foul tissue, stress, mental instability.

Hepatic failure: Due to liver enzyme, and/or jaundice, met in patients using Danazol 400 mg or more daily.

Allergic reactions: Rarely nasal congestion, rash.

Central nervous system: dizziness, headache, sleep disorders, fatigue, shudder. Rarely mildly paralysis in limbs, changing appetite, and chills. stomach: gastritis, rarely vomiting, nausea, and constipation.

Muscle muscle: Muscle or spasms, stiffness, swelling of joints, back pain, neck, or limb.

Urinary genitals: bloody urination.

Unwanted effect on heart rate and blood pressure: Some patients may have an increase in heart rate and hypertension. Benigned intracranial turbocharger and visual disorders may occur.

Other undesirable effects: Increasing insulin demand in diabetes patients, hair loss.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Kupdina drugs contraindicated in the following cases:

Abnormal genital bleeding.

Impaired liver, kidney, or heart function.

Pregnant and lactating women.

Be cautious when using

periodically monitor liver and kidney function when using Danazol because Danazol can damage these organs. In fact, the liver tumor has been encountered for long -term treatment. Danazol used caution in patients with hypercholesterolemia due to danazol can reduce HDL, cholesterol transport agent out of the vascular wall and increase LDL with cholesterol to the vascular wall.

Danazol may have a male fetal effect, so avoid for pregnant women, and should use hormone contraception should be used during treatment. Do not use Danazol for nursing women.

Use cautiously in children and adolescents because the drug can cause early puberty in boys, causing masculinity in girls, and early bone head in both boys and girls. 3-4 months should check the quality of semen (measure the volume, viscosity, the total number of sperm and the movement of sperm) during the treatment process with Danazol, especially for minors. If there is abnormal, should stop treatment.

Danazol should be used cautiously in patients with cardiovascular disorders, liver dysfunction and kidney function because the disease may be severe due to water stasis. Avoid use in patients with severe functional impairment.

Use caution in patients with diabetes, patients with red blood cells, blood lipid disorders, migraine patients or epilepsy.

Do not use Danazol in patients with sexual bleeding has not been diagnosed, cancer patients depend on androgen. Used with 17α-alkyl derivatives may increase the risk of liver damage, if used simultaneously, it is necessary to check the liver function during the treatment process.

Do not use drugs in patients with thrombosis or a history of thrombosis.

very careful when using Danazol in children and minors because it can cause early gender development in men, causing masculinity in women and can cause early closing bone cartilage in both sexes.

Use caona danazol carefully in patients with porphyrin metabolic disorders. In the event that the symptoms of androgen effects are occurred, the danazol must be stopped because the symptoms will not recover if they continue to use the drug.

The ability to drive and operate machinery

Danazol can cause dizziness, headache and fatigue so patients use drugs should not drive or operate machinery.

Pregnancy

should not use Danazol in pregnant women due to the effects of Androgen, causing female fetal men and should use contraception without hormones during treatment.

breastfeeding period

Avoid using Danazol in breastfeeding women due to the effects of Androgen on breastfeeding.

Drug interaction

carbamazepin: Carbamazebin simultaneous use with Danazol can increase the time of selling and reducing the clearance of carbamazebin, leading to an increase in plasma carbamazein levels.

Cyclosporin: Danazole inhibits metabolic leads to increased cyclosporin levels.

tacrolimus: Danazole inhibits metabolism leads to increased concentration of Tacrolimus immunological inhibitors.

warfarin: Danazol can increase the side effects of anticoagulants Warfarin.

Statins: Sharing danazol with statin drugs that can cause muscle globin.

insulin: Patients with diabetes need to increase insulin dose.

Testing: Danazol treatment may affect testosteron, Androstenedion and Dehydroepiandrostrosteron.

Storage

Store at room temperature no more than 30 ° C.

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