L-Stafloxin 500 Stella Treatment of infection (2 blisters x 7 tablets)

Precautions when using

tendonitis and tendon rupture

Tenditis may rarely occur. Most often associated with Achille tendons and can lead to tendons. The risk of rising tendonitis and tendons in the elderly, patients taking corticosteroids and patients taking a dose of 1000mg levofloxacin per day. If suspected of tendonitis, immediately stop treatment with levofloxacin.

Diseases related to Clostridium difficile

diarrhea, especially if severe, persistent or bloody, during or after treatment with levofloxacin, may be a symptom of the disease related to Clostridium difficile, the most severe form is fake colitis. If suspected fake colitis, levofloxacin should be stopped immediately.

Patients with renal failure

Because levofloxacin is excreted mainly through the kidneys, the dose adjustment of levofloxacin in patients with renal failure.

Patients with glucose-6-phosphate dehydrogenase

Patients with potential defects or truly active defects of glucose-6-phosphate dehydrogenase can be prone to hemolytic reactions when treated with quinolon antibacterial drugs, so caution should be used with levofloxacin.

Patients are susceptible to convulsions

levofloxacin should be used carefully in patients with convulsions, such as patients who have had previous central nervous system damage.

Blood sugar disorders

As well as all Quinolon drugs, there have been reports on hypoglycemia and hyperglycemia, usually in patients with diabetes being treated simultaneously with an oral hypoglycemic drug (such as glibenclamid) or with insulin, in these diabetes, should monitor blood sugar carefully.

Be careful when using fluoroquinolon, including levofloxacin, in patients who know there are risk factors that extend about QT: congenital QT syndrome, simultaneous use of drugs that extend about QT (such as anti -arrhythmia IA and III, 3 -ring antidepressants, macrolid imbalance, non -effective electrolyte imbalance (such as hypotension, magnesi) Age, cardiovascular disease (such as heart failure, myocardial infarction, slow heart rate).

My body weakness

Be careful in people with myasthenia gravis because the manifestations may be worse.

Effects on central nervous system

There have been notifications on adverse reactions such as mental disorders, increased intracranial pressure, stimulating central nervous system leading to convulsions, trembling, restlessness, headache, insomnia, depression, confusion, hallucinations, nightmares, intentions or suicide (rare) actions when using quinolones, even when used at the first dose. If these adverse reactions occur while using levofloxacin, it is necessary to stop the drug and take appropriate symptomatic management measures. Be careful when used for patients with central neurological diseases such as epilepsy, cerebral artery ... because they can increase the risk of seizures.

Sensitive reaction

Hypersensitivity reactions with many different clinical manifestations, even anaphylaxis when using quinolones, including levofloxacin, has been informed. It is necessary to stop using as soon as there are the first signs of hypersensitivity reactions and apply appropriate measures.

Hypersensitivity to light to severe light has been informed with many Fluoroquinolon antibiotics, including levofloxacin (although up to now, this adverse reaction rate when using Levofloxacin is very low

Serious reactions are likely to not recover and cause disabilities, including tendonitis, tendon, peripheral neuropathy and adverse effects on the central nervous system.

Fluoroquinolon antibiotics are associated with serious harmful reactions that can cause disabilities and non -recovery on different organs of the body. These reactions may appear simultaneously on the same patient. Harmful reactions are often recorded including tendonitis, tendon, joint pain, muscle pain, peripheral neuropathy and adverse effects on the central nervous system (hallucinations, anxiety, depression, insomnia, severe headaches and confusion). These reactions may occur within hours to a few weeks after using the drug. Patients at any age or no risk factors that exist before may have these harmful reactions.

Stop using the drug as soon as there are signs or first symptoms of any serious harmful reactions. In addition, avoid using Fluoroquinolon antibiotics for patients who have had serious reactions related to fluoroquinolon.

The ability to drive and operate machinery

Some unwanted effects (such as dizziness, dizziness, drowsiness, visual disorders) can reduce the ability to focus and react of the patient, so it can cause risks in situations where these capabilities play a particularly important role (such as driving or operating machinery).

Pregnancy

Studies on fertility in animals have not brought specific benefits. However, in human lack of information and due to the risk of degeneration based on fluoroquinolon's experiment, the cartilage supports the growing body weight, Levofloxacin is not used for pregnant women.

Breastfeeding period

levofloxacin is not used for breastfeeding women.

Drug interaction

iron salt, antacids containing magnesi or aluminum: Levofloxacin absorption is significantly reduced when using iron salt, or antacids containing magnesi or aluminum with levofloxacin.

Theophylllin, fenbufen or similar nonsteroidal anti -inflammatory drugs: Brain seizure threshold can be significantly reduced when used simultaneously with quinolon with theophyllin, nonsteroidal anti -inflammatory drugs, or drugs that reduce seizures threshold. When the presence of fenbufen concentration of levofloxacin is about 13% higher than when used.

Sucralfate: Levofloxacin's bioavailability is significantly reduced when used with sucralfat. If the patient uses both sucralfat and levofloxacin, it is best to take sucralfat 2 hours after taking Levofloxacin.

Probenecid and cimetidine: Through statistics, Probenecid and cimetidine have a significant influence on the elimination of levofloxacin. Levofloxacin's kidney clearance decreased by 24% due to cimetidine and 34% due to probenecid.

warfarin: Due to the announcement of Warfarin increases the effect when used with levofloxacin, it is necessary to monitor the coagulation indicators when using these two drugs simultaneously.

Hypoglycemic drugs: Concomitance with levofloxacin may increase the risk of blood sugar disorders, need closely monitoring.

Cavalry of the drug: Due to no studies on the correspondence of the drug, not mixing this drug with other drugs.