Lacipil 4mg GSK tablets treat hypertension (4 blisters x 7 tablets)

Dosage form Box of 4 blisters x 7 tablets
Specifications Lacidipine

Ingredient

Composition information	Content
Lacidipine	4mg

Uses

Indications

lacipil® is used in the treatment of hypertension as a single therapy or combined with other hypertension drugs such as beta blockers, diuretic and angiotensin transfer enzymes (ACE).

Pharmacological

lacidipine is a powerful and specific antagonistic antagonist with high selective effect for calcium channels in blood vessel smooth muscles. The main effect of the drug is peripheral artery dilatation, reducing peripheral blood vessel resistance and reducing blood pressure.

Observed that the phenomenon of about QTC is very small in volunteers after taking Lacipil 4 mg.

In a double blind study, randomly lasting for 4 years Elsa, the main criteria for the effectiveness of atherosclerosis is the thickness of the central layer of the carotid artery (IMT) measured by ultrasound. The results in patients treated with lacipil show the effectiveness of significantly changing the endothelial thickness of the carotid artery, suitable for the anti -atherosclerotic effect of the drug.

Pharmacokinetics

absorption

After drinking, lacidipine absorbed quickly but few from the gastrointestinal tract and mostly transformed for the first time through the liver. Absolute bioavailability is about 10%on average. Plasma peak concentration is achieved after about 30 to 150 minutes.

Distribution

Lacipil is connected to protein (more than 95%), including albumin and alpha-1-glycoprotein.

Metabolism

There are 4 main metabolites but these metabolites have less pharmacological effects. The drug is excreted mainly due to the metabolism through the liver (related to P450 CYP3A4). There is no evidence that lacidipine causes induction or inhibition of liver enzymes.

Elimination

About 70% of the dose is eliminated in the form of metabolites through feces and the rest is metabolite through the urine. Lacidipine average sale time is about 13 and 19 hours in a stable state.

Before taking Lacipil 4mg GSK tablets treat hypertension (4 blisters x 7 tablets)

How to use

Should take medicine at fixed hours a day, it is best to take the medicine in the morning, take the same or not with food.

If the dose is half of 4 mg, the other half should be held in the blister and used within 48 hours.

Dosage

Starting dose: 2 mg x 1 time/day.

Treatment of hypertension should be adjusted according to the severity of the disease and the response of each patient.

can increase the dose to 4 mg and if necessary to increase to 6 mg after a suitable time to achieve the sufficient pharmacological effects of the drug. In fact, this time is not less than 3 to 4 weeks unless clinically requires faster dose increase.

Can maintain dose without time limit.

Hepatic failure: No dose adjustments in patients with mild and medium liver failure. There is no enough data to recommend the use of drugs in patients Hepatitis severe.

Renal failure: No dose adjustment in patients with renal failure due to lacidipine does not excreted through the kidneys.

Children: No experience in lacidipine treatment for children.

Elderly: No dose adjustment.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

Common perpendicular peripheral vasodilation associated with hypotension and tachycardia. In theory, it is possible to have a slow heart rate or atrial conductivity.

There is no specific antidote. The standard treatment should be used to monitor the heart function and apply appropriate supportive treatments.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

Common, ADR> 1/100

Nervous system: headache, dizziness.

Heart: Beat the chest drum, tachycardia.

circuit: flushed.

Digestive: Stomach discomfort, vomiting.

Skin and soft tissue: Red rash (Red rash, itching).

Kidney and urinary: urine.

Body: weakness, edema.

Uncommon, 1/1000

Heart: worsen the hidden, fainting, hypotension.

Gastrointestinal: gum hyperplasia.

Rare, 1/10000

Mental:. depression

Nervous system: Run.

Skin and soft tissue: Evaluation, urticaria .

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

contraindicated

lacipil® contraindicated in the following cases:

Hypersensitivity to any component of the drug.

Be cautious when using

In specialized studies, lacidipine does not show an impact on the spontaneous function of the atrial sinus button or causing prolonged transmission in the atrial node. However, it is important to note the theory, a calcium antagonistic drug capable of acting on the operation of the atrial and atrial node.

As noted by other dihydropyridine calcium antagonists, should be cautious when taking lacipil in patients with congenital or congested QT intervals. Be cautious when taking Lacipil in patients treated simultaneously with known drugs that extend the distance of QT such as anti -arrhyths group I and III, 3 -round antidepressants, some anti -psychotic drugs, antibiotics (such as erythromycin) and several antihistamines (such as Terfenadine).

Like other antagonistic drugs, should be cautious when taking lacipil in patients with poor heart reserves.

Like other dihydropyridin calcium antagonists, should be cautious when taking lacipil for patients with unstable angina.

Should be cautious when taking lacipil in new patients with myocardial infarction.

Should be cautious when taking lacipil in patients with liver failure because it can increase the effect of lowering blood pressure.

There is no evidence that lacipil reduces glucose tolerance or changes in blood sugar control.

The ability to drive and operate machinery

No report.

Pregnancy

There is no data on lacipil's safety in pregnant women. Animal research does not show a teratogenic effect or a delay in fetal development.

Should only use lacipil for pregnant women when the benefits bring mothers outstanding unwanted effects that can occur for the fetus or babies.

Consider the possibility of lacipil that can cause uterine muscle relaxation in pregnant women monthly.

Lactation period

Research on animals shows lacidipine (or its metabolic substances) can be excreted into breast milk.

Should only use lacipil for breastfeeding mothers when the benefit gives the mother superior unwanted effects that can occur for the fetus or babies.

Medicinal interaction

Use lacipil in combination with other drugs that have other hypotension effects, including drugs that treat hypertension (such as diuretics, beta blockers or angiotensin transfer enzymes) may increase the effect of lowering blood pressure. However, specific interactive problems in studies with common hypertension medications (such as beta blockers and diuretic) or with digoxin, tolbutamid or warfarin.

Lacipil concentration in plasma may increase when used simultaneously with cimetidine.

Like other dihydropyridin, lacipil should not be taken with grapefruit juice because it can change bioavaila.

In clinical studies in kidney transplant patients with cyclosporin, lacipil reverses the reduction of plasma flow in the kidneys and the speed of glomerular filtration caused by cyclosporin.

lacidipine is known to be metabolized by Cytochrom CYP3A4, so the strong induction and inhibitors of CYP3A4 are used simultaneously that can affect the metabolism and elimination of lacidipine.

Storage

Storage below 30 ° C.

Store lacipil to avoid light, so do not remove the drug until removed to take out to take.

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