Lactulose Stella oral solution for chronic constipation, liver, liver coma (20 packs x 15ml)

Dosage form Box of 20 packs
Specifications Lactulose

Ingredient

Composition information	Content
Lactulose	10g

Uses

Indications

Lactulose Stella oral solution indicated treatment in the following cases:

Chronic constipation. Refining laxatives.

ATC code: A06AD11

Lactulose is a synthetic disaccharide, containing galactose and fructose, converted by intestinal bacteria into lactic acid and a small amount of acetic acid and formic acid. These acids reduce the pH of stool and ammonia conversion (NH3) is the diffuse form to the ammonium ionic form (NH4+) that cannot be diffused from the intestine into the bloodstream. Moreover, because the intestinal environment is more acidic in the blood, ammonia can diffuse from blood into the intestine, and then turn into an ionic ammonium ion. As a result, the content of ammonia in the blood decreases. Similarly, the absorption of amines (also involved in liver disease) may also decrease.

The main cause of the central nerve poisoning in people with liver coma is the hyperioma in the blood. Therefore, Lactulose is used in the treatment of liver brain disease, but it is necessary to take high doses. About 75 - 85% of patients have good clinical response to Lactulose treatment.

Lactulose has the effect of penetrating at the colon, so it increases the amount of water in the feces, softens the stool and stimulates intestinal motility. This effect may take 72 hours after taking the drug.

pharmacokinetics

lactulose is not absorbed in the digestive tract. Drugs to the large intestine, mainly in the form of metabolism. The drug is metabolized by bacteria, forming simple organic acids, mainly lactic acid. Excretion in urine in the form of not metabolized about 3% or less. Eliminating drugs mainly in feces.

Before taking Lactulose Stella oral solution for chronic constipation, liver, liver coma (20 packs x 15ml)

How to use

Lactulose Stella oral solution if the single dose should be used at the same time between the days. During treatment with laxatives should drink enough water (1.5 - 2 liters, equivalent to 6-8 glasses) during the day.

Dosage

Chronic constipation:

Adults: 10 - 20 g Lactulose (15 - 30 ml of oral solution)/day, divided 1-2 times/day, can increase to 40 g Lactulose (60 ml of oral solution)/day if necessary. Adjust the dose to respond to each patient.

Children: The recommended dose is as follows and adjusts the dose until there is response:

Children 1 month - 1 year: 2.5 ml of oral solution/time x 2 times/day.

Children 1 - 5 years old: 5 ml of oral solution/time x 2 times/day.

Children 5 - 10 years old: 10 ml of oral solution/time x 2 times/day.

Children 10 - 18 years old: 15 ml of oral solution // day.

Helps normal defecation for patients to do hemorrhoidal cutting procedure: 10 g Lactulose (15 ml of oral solution)/time x 2 times/day for the day before the procedure and 5 days after the procedure.

Heavy constipation due to douching with barium in the elderly: Lactulose dose is 3.3 - 6.7 g (5 -10 ml of oral solution/time x 2 times/day for 1-4 weeks.

Treatment of liver disease:

Adults: Start 20 - 30 g Lactulose (30 - 45 ml of oral solution)/time x 3 times/day. Then if necessary, every 1-2 days adjust the dose to be able to defecate soft 2-3 times/day. Clinical signs of the disease progresses in 1-3 days. Treatment time depends on clinical symptoms. The dose can be adjusted based on the pH of the fertilizer (determined by the indicator) at the beginning of the treatment and adjust the dose until the pH is about 5. This pH is usually achieved when the patient defecates 2-3 times daily. Long -term continuous treatment with lactulose can reduce severity and prevent recurrence.

Treatment of acute liver disease in adults: 20 - 30 g Lactulose (30 - 45 ml of oral solution), drink 1-2 hours apart to cause quick laxative. When a laxative effect is achieved, lactulose can be reduced to the necessary dose to have 2-3 times daily fertilizer.

Liver coma or liver coma: Use rectal sugar, recommendation of other preparations.

Children: Safety and effectiveness in children (babies to 18 years of age) have not yet been setting up liver. No data available.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms:

diarrhea, abdominal pain, alkaline infection due to hypoglycemia, dehydration, hypotension, hypokalemia.

Management:

No specific antidote, mainly symptomatic treatment.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Lactulose Stella oral solution, there are common effects (ADR) such as:

Common (1/100 ≤ ADR

Digestive: flatulence, diarrhea.

Less (1/1000 ≤ ADR

Abdominal pain, nausea, vomiting, hyperemia.

Instructions on how to handle ADR

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Lactulose Stella oral solution is contraindicated in the following cases:

Hypersensitivity to any ingredients in the preparation.

Be cautious when using

abdominal pain unknown causes before starting treatment with the drug.

Ineffective therapeutic effect after a few days of medication.

Be cautious to use lactulose in patients with lactose intolerance. The usual dose used in the treatment of constipation does not affect people with diabetes.

In the treatment of higher doses of liver disease, it is necessary to consider carefully when used for diabetes.

Use of non -adjustable and incorrect doses can lead to diarrhea and electrolyte imbalance.

Lactulose Stella contains lactose, galactose and small fructose. This medication should not be used for patients with rare genetic problems galactose intolerance, total lactase enzyme deficiency or poorly absorbed glucose-galactose. Fructose can be harmful to the teeth, need to consider the combined effect when using simultaneously the product contains fructose and diet with fructose.

Children using laxatives should be closely monitored.

The effect of the drug on the ability to drive and operate machinery

Lactulose Stella oral solution does not have or negatively affect the ability to drive and operate machinery.

Use drugs for women during pregnancy and lactation

Pregnant women

The influence during pregnancy is known to be insignificant when the mother uses Lactulose. Lactulose can be used during pregnancy.

breastfeeding women

The influence on infant breastfeeding is known to be negligible when the mother uses Lactulose. Lactulose can be used for breastfeeding women.

Interactive drug

Laxatives: not used simultaneously with other laxatives, because it causes a lot of defecation, making it difficult to accurately determine the lactulose dose for the treatment of liver brain disease.

antacids: When used simultaneously lactulose with non -absorbing antacids can affect the intestinal acid formation of lactulose.

Antibacterial drugs: Some antibacterial drugs may affect the intestinal bacteria to help metabolize lactulose. However, Neomycin can be used simultaneously in the treatment of liver brain disease.

Tyeum of drugs

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.

Storage

The posterior expiry date: 30 days from the first day of opening.

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