Lambertu tablets 60mg Davipharm treat myasthenia gravis (6 blisters x 10 tablets)

Dosage form Box of 6 blisters x 10 tablets
Specifications Pyridostigmin bromid

Ingredient

Composition information	Content
Pyridostigmin bromid	60mg

Uses

Indications

Lambertu medicine is indicated in the following cases:

pyridostigmin is used in the treatment of myasthenia gravis. Myasthenia gravis. The distance between the doses of pyridostigmin is longer than Neostigmin, which facilitates the treatment of myasthenia gravis. Therefore, it is possible to combine pyridostigmin with Neostigmin in the treatment of myasthenia gravis, for example, using pyridostigmin during the day and evening, Neostigmin used in the morning.

The body -causing cholinergic response drug includes increased musculoskeletal and intestinal muscle tone, pupils, uterine spasms, bronchospasm, heartbeat slowly, increased secretion in suburban glands. Pyridostigmin has the same effect as cholin on the skeleton.

pharmacokinetic

absorption

pyridostigmin is absorbed less, with a change rate, through the digestive tract; Only about 40% of the oral dosage of Pyridostigmin is absorbed, a large amount is destroyed in the stomach. Pyridostigmin is most absorbed in the duodenum. After drinking, the drug usually works after 30-45 minutes and lasts for 3-6 hours.

Distribution

pyridostigmin is distributed in extracellular fluids. The drug cannot enter the central nervous system. The drug through the placenta and reduces the activity of the fetal plasma cholinesterase after taking high doses.

Metabolism

Hydrolyzed by cholinininology and also metabolized in the liver.

Elimination

1.5 - 4.25 hours of oral excretion. Pyridostigmin is excreted mainly in urine (in both constant form and metabolized form). A very small part is discharged through milk.

Before taking Lambertu tablets 60mg Davipharm treat myasthenia gravis (6 blisters x 10 tablets)

How to use

Lambertu medicine is used orally to treat myasthenia gravis.

Dosage may vary from day to day, depending on the disease or severe, emotional and physical stress of the patient.

The dose must be adjusted for the patient to take high doses at highest efforts (for example: 30 - 45 minutes before eating to help the patient when it is difficult to swallow). Pyridostigmin drinks with milk or food, causing unwanted effects Muscarinic.

Dosage

Adults and teenagers

Firstly, dose 30 to 60mg, every 3 to 4 hours. After that, the maintenance dose is from 60 mg to 1200mg per day (usually 600mg).

Children

The total daily dose is usually 7mg/ kg body weight (or 200mg/ m2 of the body area) divided into 5 or 6 times. The first dose may be 30 mg for children under 6 or 60mg for children 6-12 years old. This dose is increased gradually 15 - 30mg daily, until the desired effect, but the total dose does not exceed 360mg/ day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Muscarinic effect: abdominal cramps, increased intestinal motility, diarrhea, nausea, vomiting, increased salivation and bronchial fluid, sweating, pupils. Heart, hypotension, cardiac arrest.

Stop the drug immediately. Muscarinic effects are the most severe and can control them with atropine (2mg, intravenous injection, then intramuscularly, every 2-4 hours, depending on the need, to reduce shortness of breath), but to avoid overdose of Atropine.

The skeletonal effects after an overdose of pyridostigmin do not soothe when treated with atropine.

Patients with poisoning due to anti -cholinesterase drugs are not used aminophylin, morphine, phenothiazin, neuronal drugs, reserpin, sucinylcholin, Theophylin or not transmitted a large amount of fluid.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using Lambertu, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Body: Increased sweating, anorexia. Set.

Systemic: Dizziness.

Skin: Outdoor, hair loss.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Lambertu medicine is contraindicated in the following cases:

Contraindicated to use pyridostigmin in people who know how to be hypersensitivity to anti -cholineseterase drugs, or in bowel movements and mechanical urinary tract congestion.

Precautions when using

Caution should be used with pyridostigmin in epilepsy, bronchial asthma, slow heart rate, new coronary obstruction, sympathetic strength, thyroid strength, arrhythmia or stomach ulcer. Avoid taking large doses in people with large colon or reducing stomach - intestines.

In some people, pyridostigmin bromid is longer than Neostigmin's salt, in such cases, it often causes acetylcholin secretion.

When using pyridostigmin to treat myasthenia gravis, it should be remembered that, with the same cholinesterase dose, there may be different response in separate muscle groups: weak in this muscle group while increasing muscle force in other groups. The muscles in the neck and chewing muscles and swallowing are usually the first muscle group weakened when using the drug overdose. Living capacity must be measured whenever the dose increases to be able to adjust the anti -cholinesterstase dose to ensure good respiratory function.

pyridostigmin passes the placenta and excreted into breast milk. So be cautious for pregnant and lactating people.

Using drugs with anti -cholin effects or the same effect as atropine must be very careful, when the patient is also treated with pyridostigmin because overdose symptoms can be covered by pyridostigmin, or vice versa, overdose of Pyridostigmin can also be covered by Atropine and Atropine -like drugs.

To be out of reach of children.

The ability to drive and operate machinery

Not enough information about the effect of the drug on the ability to drive and operate machinery.

Pregnancy

The safety of pyridostigmin in pregnant women has not been determined, but anti -cholinesterase drugs may cause uterine irritation and cause premature births for intravenous intravenous intravenous patients near the birth period.

However, Pyridostigmin has been used during pregnancy without causing malformations for the fetus.

Observed the temporary muscle in about 10-20% of newborns, because the mother used anti -Cholinininese drugs to treat myasthenia gravis.

Therefore, the use of pyridostigmin for pregnant women needs to consider the benefits and harm to the mother and child.

Breastfeeding period

pyridostigmin excreted partially into breast milk. So should not be used when breastfeeding.

Medicinal interaction

Atropin is opposed to Muscarinic effects of pyridostigmin and this interaction is used to prevent muscarinic effects when Pyridostigmin poisoning.

dexpanthenol can work with pyridostigmin by increasing acetylcholin production.

Anti -antacistase drugs are sometimes valid to reverse the nerve -muscle blockage caused by aminoglycosides antibiotics. However, aminoglycosid antibiotics, anesthetic and some anesthetic, anti -arrhythmic drugs, and medications that obstruct muscle transmission must be used carefully in severe muscle weaknesses and the dose of pyridostigmin may have to increase accordingly.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.