Lamone 100 Stella Treatment of chronic virus hepatitis B (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Lamivudine

Ingredient

Composition information	Content
Lamivudine	100mg

Uses

indications

Lamone drugs are indicated in cases of chronic hepatitis B treatment with:

The liver disease also has evidence of the virus's copy activity, the level of alanin aminotransferase (ALT) in serum continuously increases and has historical evidence of the active hepatitis and/ or liver fibrosis.

Liver disease is lost.

Pharmacy

Pharmacological groups: Direct antivirus drugs, enzyme inhibitors in reverse code nucleosid and nucleotid.

ATC code: J05AF05.

lamivudine is metabolized in intracellular forms form triphosphate. This Triphosphate inhibits Retrovirus's DNA synthesis, including HIV virus, through competition inhibitors with reverse copying enzymes and cohesion to the virus DNA. Lamivudine also has antiviral activity causing hepatitis b.

Dynamic pharmacokinetics

lamivudine is quickly absorbed after drinking and the peak concentration in plasma is achieved after about 1 hour. The drug is absorbed slowly, but does not decrease when used with food. Birth is about 80 - 87%. The drug is connected up to 36% to plasma protein.

lamivudine through the bloody barrier with the proportion of concentrations in the cerebrospinal fluid compared to the serum concentration is about 0.12. The drug is given the placenta and is distributed into breast milk.

lamivudine is metabolized intracellular into triphosphate form with antiviral activity. Low liver metabolic drugs and are excreted mainly in a constant form by active excretion through the kidneys. The sale time from 5 to 7 hours has been reported when using the single dose.

Before taking Lamone 100 Stella Treatment of chronic virus hepatitis B (3 blisters x 10 tablets)

How to use

Lamone medicine is used by oral, regardless of meal.

Dosage

Dosage in case of chronic hepatitis B treatment:

Adults: Oral dose is 100 mg x 1 time/day.

Children over 2 years of age: Oral dose is 3 mg/kg x 1 time/day, maximum dose is 100 mg/day.

Dosage in case of patients infected with HIV and hepatitis B:

Use the appropriate dose mode.

Dosage for kidney failure:

Should reduce the dose of lamivudine in patients with medium to severe renal impairment (creatinine clearance (cc) less than 50 ml/ minute).

Dosage for adults chronic hepatitis B:

cc 30 - 49 ml/minute: The first dose 100 mg, then 50 mg x 1 time/day.

cc 15 - 29 ml/minute: The first dose 100 mg, then 25 mg x 1 time/day. cc 5 -14 ml/minute: The first dose 35 mg, then 15 mg x 1 time/day.

cc is less than 5 ml/min: the first dose 35 mg, then 10 mg x 1 time/day.

Patients with hemolysis: There is no different dose adjustment than based on creatinine clearance.

Patients with abdominal fertilizer: Unsigning.

Children: The dose should be reduced based on creatinine clearance at the same proportion as in adults.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Acute toxic research at lamivudine's very high doses on animals does not cause toxicity on any organ. Data on the consequences of superior poisoning is limited. There is no danger and the patient recovers.

There are no signs or specialized symptoms that are manifested when overdose.

How to handle

If an overdose occurs, patients should be monitored and treated appropriately. Because Lamivudine can be separated, it is possible to use the hemorrhage continuously in the treatment of overdose, although this has not been studied.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Lamone 100, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Abdominal pain, nausea, vomiting, diarrhea.

Headache, fever, rash, hair loss, difficulty living, insomnia.

cough, nose symptoms.

joint pain and muscle pain.

Increased serum concentration of enzyme creatinin phosphokinase and alanin aminotransferase enzyme (in patients who are taking lamivudine to treat chronic virus hepatitis B).

Rare, ADR

Determination of the Van.

Pancreatitis.

neutropenia and anemia (often used with zidovudin), platelet reduction, increased liver enzymes and rare cases of hepatitis occurs.

Lactic acid contamination, often accompanied by severe liver and severe fatty liver, has been reported during the treatment process with nucleoside copy enzyme inhibitors.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Lamone drugs contraindicated in the following cases:

Sensitivity to active ingredients or any excipients of the drug (excipients ingredients: microcrystallin cellulose, Povidon K30, Croscarmes sodium, stearic acid, colla -anhydrous collica, hypromellose, macrogol 6000, talc, titanium dioxyd, red iron iron oxyid).

Be cautious when using

should stop treating with lamivudine in patients with abdominal pain progresses, nausea, vomiting or accompanied by abnormal biochemical test results until pancreatitis has been excluded.

Treatment with lamivudine may be related to lactic acid infection and should stop treating if the enzyme level of aminotransferase is increasing rapidly, progressive liver, metabolic acid infection or lactic acid infection for unknown cause.

Should use lamivudine cautious in patients with large liver or other risk factors of liver disease.

In patients with chronic hepatitis B, there is a risk of hepatitis again when stopping lamivudine, which should be monitored in these patients.

Should eliminate HIV infection before starting to use lamivudine to treat hepatitis B, because it has been treated at a lower dosage, it can cause increased lamivudine resistance of the HIV virus.

may need to reduce the dose in patients with renal function.

The ability to drive and operate machinery

No report.

Pregnancy

so far there has been no adequate and controlled research on the use of lamivudine in pregnant women, so the drug is only used during pregnancy when the treatment benefits are higher than the risk of harmful to the fetus.

Breastfeeding period

lamivudine is distributed in breast milk. Because there is the possibility of serious unwanted effects due to lamivudine on breastfeeding babies, mothers should stop breastfeeding when using lamivudine to treat chronic HBV infection.

Drug interaction

lamivudine's renal excretion may be inhibited by drugs excreted mainly through active excretion in other kidneys, such as trimethoprim.

With the common preventive dose of trimethoprim does not need to reduce the dose of lamivudine unless the patient has renal failure, but to avoid simultaneous use of lamivudine with high doses of trimethoprim (such as co-trimoxazol) in pneumocystis pneumonia and toxoplasma infection.

Although there is no significant clinical interaction with zidovudin, sometimes severe anemia occurs in patients using lamivudine with zidovudin.

Lamivudine may fight against the antiviral effect of zalcitabin, these two should not be used together. Use one -time regimen including 3 nucleosids such as lamivudine and tenofovir with abacavir or didanosin that causes high levels of treatment and appears resistant, so avoid use.

Tyeum of drugs

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.

Storage

Store in closed packaging, dry place. The temperature does not exceed 30 ° C.

Other drugs

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