Lampar 5mg tablets Davipharm treat gastroesophageal reflux disease - chronic esophagus (6 blisters x 10 tablets)

Dosage form Box of 6 blisters x 10 tablets
Specifications Mosaprid citrate

Ingredient

Composition information	Content
Mosaprid citrate	5mg

Uses

Indications

Lampar 5 drugs are indicated in the case of treatment of gastrointestinal symptoms (impatient, nausea, vomiting) related to gastroesophageal reflux disease.

Pharmacokological

Mosapride is the derivative of Benzamide that has an impact in the stomach, thus increasing the stomach circulation and emptying the stomach.

Mechanism of impact: The drug is a selective transport of the 5-HT receptor. It stimulates the 5-HT receptor of the end of the stomach nerve, increasing acetylcholine secretion, resulting in an increase in stomach circulation and empty the stomach.

Experimental research in healthy adults and patients with chronic gastritis, used separately with 5 mg of mosapride citrate to enhance the hollow.

The drug increases the circulation in the stomach and duodenum after meals in volunteers. The drug has little influence in colon circulation.

The drug increases the empty process of the stomach with the liquid and thick. The increase in this process will decrease after a week of repetition.

pharmacokinetic

absorption

In healthy adults, when hungry, dose of 5 mg of mosapride citrate.

Tmax: 0.8 hours; CMAX: 30.7 μg/ ml; T1/2: 2 hours.

Distribution

99% plasma protein binding drugs (human plasma in vivo in a concentration of 1 μg/ml.

Metabolism

The metabolites are the des-fluorobenzyl compound. Mosapride Citrate metabolizes through the liver, where 4-Fluorobenzyl group is cut, then oxidizes the benzene ring at the No. 3.

Elimination

After taking 48 hours, the urine found 0.1% of the form of constant drug and 4% of the main metabolic form (Des-Fluorobenzyl compound).

Before taking Lampar 5mg tablets Davipharm treat gastroesophageal reflux disease - chronic esophagus (6 blisters x 10 tablets)

How to use

oral drugs. Take medicine before or after meals.

Dosage

Adults: Take 5 mg/time x 3 times/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose? The drug is highly connected to plasma proteins, so it cannot be removed by a cup.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Lampar 5, you may experience unwanted effects (ADR).

Uncommon, 1/1000

Hematology: Nothing hypernagus.

Digestive: diarrhea , liquid stool, dry mouth, abdominal pain, dry mouth, nausea, vomiting. liver: increase Alt (GPT).

Other: fatigue, increase neutral fat.

Rare, ADR

allergies: edema, urticaria.

Hematology: leukopenia.

digest: Disruptive taste, bloating sensation.

liver: increased AST (GOT), γ-GTP, Bilirubin.

Circulation: Brushing the chest. nerve: dizziness, wandering, headache.

Other: Run.

Unknown frequency

Skin and subcutaneous tissue: rash.

digestive: numbness in the mouth (including tongue, lips ...). liver: Acute hepatitis, liver dysfunction, jaundice.

Instructions on how to handle ADR

Should be monitored while using the drug and if any abnormalities should stop immediately and have appropriate treatment.

Notify the doctor the unwanted effects when taking the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Lampar 5 contraindicated in cases of sensitivity to mosapride or any ingredients of the drug.

Precautions when using

do not recommend continuing to use the drug if treated within 2 weeks without improved symptoms. The drug can cause hepatitis, severe liver dysfunction and jaundice. In addition, the drug can also cause symptoms such as fatigue, anorexia, more concentrated urine and yellow eye. Instruct patients to stop the drug and contact the doctor if the symptoms appear.

Do not take medicine for a long time. If during the time of using the drug has any abnormal manifestations, it is advisable to stop the drug and take appropriate treatment.

Read the instruction sheet of the drug empty the gastrointestinal tract used for oral treatment used before the X-ray test with Bari contrast drug.

The safety of this drug in children has not been proven (without clinical experience).

When using this drug for gastrointestinal symptoms related to chronic gastritis, it is recommended to assess the improvement of the gastrointestinal symptoms and consider the need for continued medication after use for a certain period of time (usually 2 weeks).

Acute hepatitis,

serious liver function impaired and jaundice may occur. Do not use mosapride citrate for a long time. While taking the drug, patients need to be carefully monitored. If any abnormalities occur, it is necessary to stop the drug and take appropriate measures. The patient should stop the drug and contact the doctor if you experience any symptoms such as fatigue, anorexia, dark urine, conjunctiva yellow ... after taking the drug.

The elderly: Because the elderly often has impaired physiological function of the liver and kidneys, should be cautious when using the drug. In case of unwanted effects, should reduce the dose.

The drug contains starch, patients with allergies to wheat (not tolerated with gluten) should not be used.

The ability to drive and operate machinery

There is no information on the effect of the drug on the ability to drive and operate machinery, but the drug may be stunned, recommend that patients should not perform high concentration jobs such as driving or operating machinery, until determining certainly does not encounter the desired effect.

Pregnancy

has not determined the safety of the drug for pregnant women. Therefore, using this drug only when the benefits are superior to the risk possible.

Breastfeeding period

Not determined the safety of the drug for nursing women. Therefore, using this drug only when the benefits are superior to the risk possible.

Drug interaction

Interact with anti -cholinergic drugs such as Atropine Sulfate, Butylscopolamine Bromide. Because when taking anti -cholinergic drugs reduces the effectiveness of the drug, should be cautious and take these drugs away from time to drink Lampar.

Mechanisms and risk factors: Because the pharmacological effect in the stomach of the drug is due to the activation of the cholinergic neurotransmitter, the anti -cholinergic drug reduces the effectiveness of the drug.

Storage

Keep the drug in the original packaging of the manufacturer, covered.

Put the drug in a dry place, avoid light, the temperature does not exceed 30 ° C and out of the reach of children.

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