Lecifex 500 Abbott drugs treat mild, medium and severe infections (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Levofloxacin

Ingredient

Composition information	Content
Levofloxacin	500mg

Uses

indications

Lecifex drugs are indicated in cases of treatment of mild, medium and severe infections caused by sensitive bacteria including:

Pneumonia is suffering from the hospital. Drugs.

Due to Fluoroquinolon antibiotics, including Lecifex® related to serious harmful reactions and non -complex urinary tract infections in some patients who can go away on their own, only Lecifex®chi patients who do not have other replacement treatment options.

Acute bacterial infections of chronic bronchitis:

Due to Fluoroquinolon antibiotics, including Lecifex® related to serious harmful reactions (see warning and caution) and acute bacterial infections of chronic bronchitis in some patients who can go away on their own, should only use Lecifex®cho patients who have no other options for replacement.

Acute sinusitis caused by bacteria:

Due to Fluoroquinolon antibiotics, including Lecifex® related to serious harmful reactions (see warning and caution) and acute sinusitis caused by bacteria in some patients who have self -cured, should only use Lecifex®ches for patients without other replacement treatment options.

Pharmacokology

Pharmacological group: Quinolon antibiotics-Fluoroquinolon group.

ATC code: J01MA12.

levofloxacin is an antibiotic of the fluoroquinolone group with wide antibacterial spectrum. Levofloxacin acts by inhibiting the subunit A unit of DNA Gyrase (Topoisomerase), which is an essential enzyme for bacterial DNA copy. The mechanism of action of levofloxacin and other Fluoroquinon antibiotics related to the inhibition of the Topoisomerase IV enzyme and DNA Gyrase (both are Typeisomerase II), enzymes need to be copied, transcribed, repaired and recombinant DNA.

The mechanism of action of antibiotics belonging to the fluoroquinolon group, including levofloxacin, is different from the antibiotics of penicillin group, cephalosporin, aminoglycosides, macrolid, and tetracyclin. Therefore, the strains of bacteria resistance to these antibiotic groups may be sensitive to levofloxacin and other quinolons.

levofloxacin has a wide antibacterial spectrum including Gram -negative and gram -positive bacteria in vitro and clinically:

Aerobic Gram -negative bacteria: Escherichia Coli, Klebsiella Pneumoniae, Proteus Mirabilis, Pseudomonas Aeruginosa, Haemophilus Influenzae, Haemophilus Para Influenzae, Moraxella Catarrhalis, Legionella Pneumophila, EnterobacterCloacael. (E.Faecalis). There have been cross -resistance between levofloxacin and some other fluoroquinolones, some other bacteria with other fluoroquinolon may be sensitive to levofloxacin.

pharmacokinetics

absorption:

Levofloxacin is absorbed quickly and almost completely after drinking, the peak concentration in plasma is achieved within 1 hour after taking 1 dose.

Distribution:

The drug is distributed into the body tissue including bronchial and lung mucosa, but the ability to penetrate into the cerebrospinal fluid is relatively poor. The concentration of drug in the lung tissue is usually 2-5 times higher than the plasma concentration. Levofloxacin links about 30-40% to plasma proteins. The average distribution volume of levofloxacin usually ranges from 74 -112 l after single dose and repeated dose 500 mg.

Metabolism:

levofloxacin is less metabolized in humans and is excreted mainly in the form of constant drugs in the urine within 48 hours, while less than 4% of the dose is found in feces for 72 hours. Under 5% of a dose of rediscovered in the form of water in the form of Desmethyl and N-Oxyd metabolites. These metabolites have little pharmacological activity.

Era:

The half -life of levofloxacin elimination is 6 - 8 hours, but this time may be longer in kidney failure. Levofloxacin is excreted in a constant form, mainly in urine. The drug is not removed by the method of hemolytic or abdominal separation.

Before taking Lecifex 500 Abbott drugs treat mild, medium and severe infections (1 blister x 10 tablets)

How to use

oral tablets. Take medicine with a full glass of water, can drink when hungry or full, do not drink with antacids containing aluminum and magnesium.

Dosage

Adults:

Pneumonia with hospital: 500 mg/1-1 times/day for 7-14 days. Date. Must use in combination with other antacids. The treatment regimen of many drugs is usually given in 12-18 months when suffering from rifampicin -resistant tuberculosis; In 18 - 24 months when suffering from anti -Isoniazid and rifampicin strains; or 24 months when suffering from anti -Isoniazid, rifampicin, ethambutol, and/or pyrazinamide strains. mg/time/day, for 10 - 14 days.

cc 20 - 50 ml/minute: The next dose decreases half. The above is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Overdose

There is no data on overdose, no overdose of the drug.

Handling

In case of an exceeding the acute, emptying the stomach by causing vomiting or gastric lavage. Patients should be monitored and supported treatment such as kidney function, giving aluminum anti -acid, magnesium or calcium -containing preparations to reduce Levofloxacin absorption. Need to maintain enough fluid for patients.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Object System Common
(> 1/100 to Uncommon (> 1/1,000 to Rare
(> 1/10,000 to EOSIN platelet reduction, neutropenia all bloody hemocytes, grain leukemia, hemolytic anemia Nursing Anorexia Special hypoglycemia in patients with diabetes Hyperglycemia, coma hypoglycemia Depression, anxiety, abnormal dreams, nightmares

mental disorders with self -dangerous behavior including suicidal ideas or trying to commit suicide

The sense of smell includes loss of smell, dysfunction, percentage disorders, taste loss, benign intracranial turbocharger Dizziness tinnitus hearing loss, reducing hearing ability Circuit Chemistry diarrhea, vomiting, nausea abdominal pain, flatulence, indigestion, constipation diarrhea - bleeding that in the very rare case may be a sign of bowel inflammation, including fake colitis, pancreatitis Phosphatese, CGT) increased blood bilirubin jaundice and serious liver damage, including cases of acute liver failure, mainly with serious hidden diseases, hepatitis Increasing sweating poisoned epidermal necrosis, Stevens-Johnson syndrome, diverse roses, light sensitive reactions, stomatitis It can be particularly important in patients with myasthenia gravis muscle pattern, tendon breakdown, ligaments, muscle torn, arthritis

general disorders and local condition

weakness fever Pain (including back pain, chest and limbs)

Notify the physician the unwanted effects when using the drug.

Stop using and consulting your doctor if: Patients with inflammation or tendon, prolonged diarrhea or become severe.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Lecifex drugs contraindicated in the following cases:

Patients with a history of hypersensitivity to levofloxacin or other antibacterial drugs of Quinolon. Year.

Caution when used

Increased risk of tendonitis and tendon. This risk increases mainly in patients over 65 years old, taking corticosteroids. Stop using drugs if pain or tendonitis.

Use caution in patients with myasthenia gravis.

Be careful when used for patients with central neuropathy diseases such as epilepsy, brain sclerosis because it may increase the risk of convulsions.

Sensitive reaction, even anaphylactic shock when using quinolones, including levofloxacin, has been notified. It is necessary to stop the drug as soon as there are the first signs of sensitive reaction and apply appropriate treatment.

Clostridium difficile colitis has been reported with many types of antibiotics including levofloxacin, which can occur from mild to life -threatening, it is important to pay attention to the accurate diagnosis of diarrhea occurring during the time when the patient is using antibiotics to take appropriate treatment measures.

Hypersensitivity to light to severe light has been reported with many fluoroquinolon antibiotics, including levofloxacin. Patients should avoid direct contact with light during treatment and 48 hours after treatment. Use cautiously in patients who are taking diabetes drugs.

Using quinolones can cause QT range on the center of electrocardiogram in some patients and some rarity of the arrhythmia. Therefore, it is necessary to avoid use in patients with prolonged QT, patients with hypokalemia, patients who are using anti -arrhythmic drugs IA (Quinidin, Procainamid, ...) or Group III (Amiodaron, Sotalol ...).

In patients with renal impairment: adjust the dose based on creatinine clearance.

Serious reactions are likely to not recover and cause disabilities, including tendonitis, tendon, peripheral neuropathy and adverse effects on the central nervous system.

Fluoroquinolon antibiotics are associated with serious harmful reactions that can cause disabilities and non -recovery on different organs of the body. These reactions may appear simultaneously on the same patient. Harmful reactions are often recorded including tendonitis, tendon, joint pain, muscle pain, peripheral neuropathy and adverse effects on the central nervous system (hallucinations, anxiety, depression, insomnia, severe headaches and confusion). These reactions may occur within hours to a few weeks after using the drug. Patients at any age or no risk factors that exist before can encounter the harmful reactions.

Stop using the drug as soon as there are signs or first symptoms of any serious harmful reactions. In addition, avoid using Fluoroquinolon antibiotics for patients who have had serious reactions related to fluoroquinolon.

Use drugs for women during pregnancy and lactation

There are no data on humans. Because fluoroquinolon causes degeneration of joints carrying body weight in adult animals, levofloxacin is not recommended for pregnant and lactating women.

The effect of the drug on the ability to drive and operate machinery

levofloxacin can cause dizziness, so this sensitivity should be determined before using while driving or operating machinery.

Interactive drug

iron salt, antacids containing magnesi or aluminum, didanosin:

iron salt, antacids containing magnesi or aluminum, didanosin (only didanosin products with aluminum or magnesium containing cushions) can reduce the absorption of levofoxacin. Simultaneous use of fluoroquinolon with multi-vitamin contains zinc that reduces the oral absorption of fluoroquinolon. Therefore, it is not advisable to use preparations containing chemotherapy two or three such as iron salts, zinc salts or antacids containing magnesi or aluminum, didanosine (indicating didanosine formulas with aluminum or magnesium containing cushions) before or after 2 hours using levofloxacin. Calcium salt has a minimum effect on oral absorption of levofloxacin.

sucralfat:

Levofloxacin's bioavailability is significant when the drug is used with sucralfat. If the patient is simultaneously using sucralfat and levofloxacin, it is best to use sucrafat 2 hours after using levofloxacin.

Theophylllin, fenbufen or nonsteroidal anti -inflammatory drugs are similar:

In a clinical study, levofloxacin's pharmacokinetic interactions are not seen with theophyllin. However, the threshold of seizures in the brain can be significantly reduced when shared with Quinolon with theophyllin, anti-inflammatory drugs-steroids

Theophyllin. However, the strategy of seizures in the brain can be significantly reduced when shared with Quinolon with theophyllin, anti-inflammatory drugs or other drugs or other drugs that lower the seizure threshold. Levofloxacin concentration is about 13% higher than being fenbufen compared to when used alone.

probenecid and cimetidine:

Be careful when using levofloxacin along with drugs that affect the excretion of renal tubules such as probenecid and cimetidine, especially in patients with renal impairment.

Probenecid prevents Levofloxacin secretion.

The effect of levofloxacin on other drugs

ciclosporin: half -life of ciclosporin increases 33% when used with levofloxacin.

Vitamin K antagonists: Levofloxacin can increase Warfarin's anticoagulant effect. Increasing blood clotting time (PT/INR) and/or bleeding, may be serious, which has been reported in patients treated Levofloxacin in combination with vitamin K antagonistic drugs (eg warfarin). Therefore, it is necessary to monitor blood clotting tests in patients treated with vitamin K antagonists.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

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