Lecifex 500mg Abbott medicine for mild, medium and severe infections (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Levofloxacin

Ingredient

Composition information	Content
Levofloxacin	500mg

Uses

indications

Lecifex® 500mg drug is indicated for use in mild, medium and severe infections caused by sensitive bacteria including:

Pneumonia is suffering from the hospital. Fluoroquinolon, including Lecifex® related to serious harmful reactions and non -complicated urinary tract infections in some patients who can go away on their own, should only use Lecifex® for patients who have no other treatment options instead. Acute bacterial infections of chronic bronchitis in some patients can go away on their own, only Lecifex® should be used for patients who do not have other replacement treatment options. Humanity has no other replacement treatment options.

ATC code: J01MA12.

levofloxacin is an antibiotic of the fluoroquinolone group with wide antibacterial spectrum. Levofloxacin acts by inhibiting the subunit A unit of DNA Gyrase (Topoisomerase), which is an essential enzyme for bacterial DNA copy. The mechanism of action of levofloxacin and other Fluoroquinon antibiotics related to the inhibition of the Topoisomerase IV enzyme and DNA Gyrase (both are Typeisomerase II), enzymes need to be copied, transcribed, repaired and recombinant DNA.

The mechanism of action of antibiotics belonging to the fluoroquinolon group, including levofloxacin, is different from the antibiotics of penicillin group, cephalosporin, aminoglycosides, macrolid, and tetracyclin. Therefore, the strains of bacteria resistance to these antibiotic groups may be sensitive to levofloxacin and other quinolons.

levofloxacin has a wide antibacterial spectrum including Gram -negative and gram -positive bacteria in vitro and clinically:

Aerobic Gram -negative Gram bacteria: Escherichia Coli, Klebsiella Pneumoniae, Proteus Mirabilis, Pseudomonas Aeruginosa, Haemophilus Influenzae, Haemophilus parainfluenzae, Moraxella CatVrhalis, Legionella Pneumophila Clockael. Faecalis). The crossroads between levofloxacin and some other fluoroquinolones, some other bacteria with other fluoroquinolones may be sensitive to levofloxacin.

Pharmacokinetics

absorption

Levofloxacin is absorbed quickly and almost completely after drinking, the peak concentration in plasma is achieved within 1 hour after taking 1 dose.

Distribution

The drug is distributed into the body tissue including bronchial and lung mucosa, but the ability to penetrate into the cerebrospinal fluid is relatively poor. The concentration of drugs in the lung tissue is usually 2-5 times higher than the plasma concentration.

levofloxacin binds about 30-40% to plasma proteins. The average distribution volume of levofloxacin is usually between 74 - 112 l after single dose and repeated dose 500 mg.

Metabolism

levofloxacin is less metabolized in humans and is excreted mainly in the form of air -to -air drugs in the urine within 48 hours, while less than 4% of the dose is found in feces for 72 hours. Less than 5% of a dose of rediscovered in urine in the form of Desmethyl and N-Oxyd metabolites. These metabolites have little pharmacological activity.

Elimination

The half -life of levofloxacin elimination is 6 - 8 hours, but this time may be longer in kidney failure. Levofloxacin is excreted in a constant form, mainly in urine. The drug is not removed by the method of hemolytic or abdominal separation.

Before taking Lecifex 500mg Abbott medicine for mild, medium and severe infections (2 blisters x 10 tablets)

How to use

Take medicine with a full glass of water, can be taken when hungry or full, do not drink with aluminum antacids and magnesium.

Dosage

The dose of Lecifex® 500mg depends on each specification:

Pneumonia suffer from hospital: 1 tablet/1-2 times/day, treat for 7-14 days. tablets/day/day, treatment for 7-10 days. In combination with other anti -tuberculosis drugs. Kidney failure: Despite the constant starting dose in patients with renal impairment, the next dose of levofloxacin should be adjusted based on creatinine clearance (CC):

cc 20 - 50 ml/minute: The next dose decreases half. When overdose? Patients should be monitored and supported treatment such as kidney function, giving aluminum anti -acid, magnesium or calcium -containing preparations to reduce Levofloxacin absorption. Need to maintain enough fluid for patients.

What to do when forgetting a dose?

Side Effects

Common side effects (≥1/100 to

Insomnia, headache, dizziness, diarrhea, nausea, vomiting, increased liver enzymes.

Side effects are less common (≥1/1,000 to

Fungal infections include Candida Fungal infection, anti -pathogens. sense.

Difficulty breathing. Rare side use (≥1/10,000 to

platelet reduction, neutropenia. Sense.

visual disorders like view. ).

Fever. Thinking suicide or trying to commit suicide. Helpses, allergic pneumonia. Diverse rash, light sensitive reactions, stomatitis. Harmful encountered when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Do not use Lecifex 500mg if the patient is one of the following cases:

allergies or a history of hypersensitivity to any ingredients of the drug. Youth.

Women who are pregnant or nursing.

Be cautious when using

Increased risk of tendonitis and tendon rupture, mainly in patients over 65 years old, taking corticosteroids. Stop using drugs if pain or tendonitis. It is necessary to stop the drug as soon as there are the first signs of sensitive reaction and apply appropriate treatment. It should be noted to accurately diagnose cases of diarrhea during the time when the patient is using antibiotics for appropriate treatment. Patients should avoid direct contact with light during treatment and 48 hours after treatment. Therefore, it is necessary to avoid use on patients with long -term QT, patients with hypokalemia, patients are using anti -arrhythmia IA (Quinidin, Procainamid, ...) or Group III (Amiodaron, Sotalol, ...). And causing disabilities, including tendonitis, tendon, peripheral neuropathy and adverse effects on the central nervous system. These reactions may appear simultaneously on the same patient. Harmful reactions are often recorded including tendonitis, tendon, joint pain, muscle pain, peripheral neuropathy and adverse effects on the central nervous system (hallucinations, anxiety, depression, insomnia, severe headaches and confusion). These reactions may occur within hours to a few weeks after using the drug. Patients at any age or no risk factors that exist before may experience the harmful reactions. In addition, avoid using Fluoroquinolon antibiotics for patients who have experienced serious reactions related to fluoroquinolon.

The effect of the drug on the ability to drive and operate machinery

levofloxacin can cause dizziness, so this sensitivity should be determined before using while driving or operating machinery.

Use drugs for women during pregnancy and lactation

There are no data on humans. Because fluoroquinolon causes degeneration of joints carrying body weight in adult animals, levofloxacin is not recommended for pregnant and lactating women.

Drug interaction

The effect of other drugs on levofloxacin:

iron salt, antacids containing magnesi or aluminum, didanosin (indicating didanosine formulas with aluminum or magnesium containing cushions): can reduce Levofoxacin absorption. Simultaneous use of fluoroquinolon with multi-vitamin contains zinc that reduces the oral absorption of fluoroquinolon. Therefore, it is not advisable to use preparations containing chemotherapy two or three such as iron salts, zinc salts or antacids containing magnesi or aluminum, didanosine (indicating didanosine formulas with aluminum or magnesium containing cushions) before or after 2 hours using levofloxacin. Calcium salts have minimal effects on oral absorption of levofloxacin. If the patient is using Sucralfat and Levofloxacin simultaneously, it is best to use sucrafat 2 hours after using Levofloxacin. However, the strategy of seizures in the brain can be significantly reduced when shared with Quinolon with theophyllin, anti-inflammatory drugs or other drugs or other drugs that lower the seizure threshold. Levofloxacin concentration is about 13% higher than when being fenbufen compared to when used alone. levofloxacin.

The effect of levofloxacin on other drugs:

ciclosporin: The half -life of Ciclosporin increases 33% when used with levofloxacin. Increasing blood clotting time (PT/INR) and/or bleeding, may be serious, which has been reported in patients treated Levofloxacin in combination with vitamin K antagonistic drugs (eg warfarin). Therefore, it is necessary to monitor blood clotting tests in patients treated with vitamin K antagonistic drugs.

Storage

Leave in a dry place, avoid light, the temperature does not exceed 30 ° C.

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