Lercastad 10 Stella tablets treat primary hypertension from mild to medium (6 blisters x 10 tablets)

Dosage form Box of 6 blisters x 10 tablets
Specifications Lercanidipine

Ingredient

Composition information	Content
Lercanidipine	10mg

Uses

indicated

lercastad 10 is indicated in case of:

Treatment of primary hypertension from mild to medium. Lercanidipin is a calcium channel blocker of the dihydropyridine group, inhibiting calcium flow through cell membranes to blood vessel and heart muscle muscles. The mechanism of lowering blood pressure is due to the impact of direct blood vessel muscle relaxation, which reduces peripheral resistance. Despite the short selling time, Lercanidipine has a prolonged hypotension due to the high coefficient of distribution in the membrane and does not cause negative muscle effects due to high selective selection on the circuit. Because lercanidipin hydrochloride vasodilion slowly starts, rarely rarely symptoms of acute blood pressure with fast heart palpitations due to reflexes on high blood pressure patients.

Pharmacokinetics

absorption

Lercanidipin is completely absorbed through the digestive tract after drinking but is significantly first metabolism. The bioavailability of the drug is low, but increases when the presence of food. The peak concentration in plasma is achieved after taking 1.5 - 3 hours.

Distribution

Lercanidipin is widely and quickly distributed. Over 98% Lercanidipine binds to plasma proteins.

Metabolism

Lercanidipine is strongly metabolized, mainly by the cytochrom P450 isoenzyme, into non -active metabolites.

Elimination

About 50% of the dose is excreted in the urine. The last waste sale time is about 2-5 hours but other studies using more sensitive quantitative methods have given 8-10 hours.

Before taking Lercastad 10 Stella tablets treat primary hypertension from mild to medium (6 blisters x 10 tablets)

How to use

Lercastad 10 is taken at least 15 minutes before meals.

Dosage

Dosage is 10mg, 1 time/day, the dose may increase to 20mg depending on the response of each patient.

Due to the maximum hypotension effect only after 2 weeks, the adjustment of the dose should be done slowly.

Treatment for the elderly

Need to monitor carefully when starting treatment.

Treatment for patients with kidney or liver dysfunction

Need to monitor carefully when starting treatment for patients with mild to moderate liver and kidney dysfunction. The usual dose may be tolerated by this group of objects, so it is necessary to be careful when adjusting the dose to 20mg daily. The impact of lowering blood pressure in patients with increased liver failure, so the dose adjustment should be considered.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Similar to other drugs of the dihydropyridine group, overdose can cause excessive vasodilation with significant hypotension and fast heartbeat.

Treatment

Cases of severe hypotension, slow and unconscious heart rate, heart -proofing atropine intravenous injection may be helpful for the case of slow heart rate. Due to the prolonged pharmacological impact of Lercanidipin, the patient's cardiovascular condition should be monitored for at least 24 hours.

There is no information about the value of hemorrhage. Because the drug has high oil body, plasma concentration does not indicate the time of the dangerous stage and the process of blood separation may not be effective.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Lercastad 10, you may experience unwanted effects (ADR).

Common, ADR> 1/100

No report.

Uncommon, 1/1000

Neurological: headache, dizziness.

Cardiovascular: Peripheral edema, fast, nervous, flushed heart.

Rare ADR

Neurological: Drop, faint.

Body: weakness, fatigue, increased sensitivity.

Skin and subcutaneous tissue: rash.

musculoskeletal: muscle pain.

Cardiovascular: angina, myocardial infarction . Digestive: Nausea, indigestion , diarrhea, abdominal pain, vomiting.

Teeth: gum hypertrophy.

Metabolism: Inchoqual levels of serum transaminase. blood vessels: Hypotenem pressure.

Kidney and urinary: urinate a lot.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Lercastad 10 contraindicated in the following cases:

Too hypersensitivity to lercanidipin, dihydropyridine group or any ingredients in the formula.

Pregnant and lactating women.

Women are likely to get pregnant unless effective contraception.

Conclusion of left ventricular heart.

Heart failure congestion has not been treated.

Unstable angina.

In 1 month after myocardial infarction.

Simultaneously used with strong inhibitors CYP3A4, cyclosporin, grapefruit juice.

Patients with severe liver or kidney failure (CLCR

Children under 18 years old.

Be cautious when using

should be carefully monitored when Lercanidipin is indicated for patients with pathological sinus button syndrome (in case of not using a pacemaker), patients with left ventricular dysfunction. Increasing cardiovascular risk in ischemic patients with short -effect dihydropyridine use, so the extended impact lercanidipine is proposed for this object.

The ability to drive and operate machinery

Based on clinical experience, Lercanidipin does not reduce the ability to drive and operate machinery. However, it is necessary to be carefully monitored by the side effects that occur dizziness, weakness, fatigue, and falling asleep but rare.

Pregnancy

Inexperienced in using lercanidipin clinically for pregnant and lactating women but other drugs belonging to the dihydropyridine group is known to cause teratogenic in animals, so Lercanidipine should not be indicated for pregnant women or possibly pregnant unless effective contraceptive measures.

The period of breastfeeding

Due to high oil body properties, Lercanidipin can be distributed into milk. Therefore, the drug should not be prescribed for nursing women.

Interaction

alcohol: Avoid simultaneous use because alcohol is likely to affect blood pressure drugs due to vasodilation.

CYP3A4 inhibitors and touch group: Lercanidipin is metabolized by CYP3A4 enzymes, therefore, simultaneously used with drugs that inhibit and touch the CYP3A4 enzyme will cause interactions to the metabolism and elimination of Lercanidipine.

A study of interaction with strong CYP3A4 inhibitors like ketoconazole shows an increase in lercanidipine concentration in plasma.

Be cautious when using Lercanidipin simultaneously with CYP3A4 induction substances such as anti -convulsions ( phenytoin , carbamazepine) and rifampicin because of the impact of pressure loss, so it is necessary to monitor blood pressure more often.

Midazolam and the substrates of CYP3A4: simultaneously use Lercanidipin at the dose of 20mg and Midazolam oral Midazolam for older volunteers, Lercanidipine absorption level increases approximately 40% and reduced absorption rate (TMAX decreases from 1.75 to 3 hours). Midazolam concentration is not changed. Should be cautious when indicated simultaneously lercanidipine and substrates of CYP3A4 such as terfenadin, astemizol, anti -arrhythmic drug group III such as amiodaron and quinidine.

Diuretics, enzyme inhibitors and beta blockers: When used simultaneously lercanidipine with metoprolol , a beta blocker is excreted mainly through the liver, methoProlol bioavailability does not change but Lercanidipine is reduced by 50%. This impact also occurs with other drugs in this group because beta blockers reduce blood flow to the liver. Therefore, Lercanidipin is used safely when used simultaneously with beta blockers but must adjust the dose.

Cimetidine: Be careful when using cimetidine dose over 80mg because of bioavailability and pressure reduction effect of lercanidipine may increase.

Digoxin : simultaneous treatment of Digoxin and Lercanidipin 20mg, Digoxin's cmax concentration increases by 33% while AUC and renal clearance have no significant change. The patient is treated simultaneously, digoxin should be closely monitored for signs of Digoxin poisoning.

Cyclosporin: The concentration of lercanidipin and cyclosporin in serum both increases when used simultaneously.

Grapefruit juice: Lercanidipin is susceptible to inhibited metabolism by grapefruit juice, resulting in a result of increased bioavailability and hypotension.

Storage

In closed packaging, dry place, avoiding light. The temperature does not exceed 30 ° C.

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