Lertazin 5mg Krka tablets treat allergic rhinitis, urticaria (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Levocetirizine

Ingredient

Composition informationContent
Levocetirizine5mg

Uses

Indications

Lertazin 5 mg is indicated for treatment in case of treatment of histamine allergies such as: Allergic rhinitis , urticaria ...

Pharmacokology

levocetirizine is a strong antihistamine drug, piperazine derivative.

levocetirizine, optical ratness R of Cetirizine, has a selective antagonistic effect in H1 receptor. Studies have shown that levocetirizine has a high affinity for H1 receptors (ki = 3.2 nmol/l). Levocetirizine has twice higher than Cetirizine (KI 6.3 nmol/l). Levocetirizine is separated from the H1 receptor with a selling time of 115 ± 38 minutes.

Pharmacological studies in volunteers prove that with levocetirizine at half dose is equal to cetirizine on the skin and hair. In In vitro study showed that Levocetirizine inhibits the Eotaxine that causes the relocation of eosin leukemia through skin and lung cells. A pharmacokinetics study showed three main inhibited effects of levocetirizine 5 mg in the first 6 hours of allergic reactions to pollen, compared to 14 patients using placebo, VCAM-1 release inhibitors, adjusting the permeability of the vascular wall and eosinophilia. The effectiveness and safety of levocetirizine in a number of double blind studies, placebo, clinical trials conducted in adult patients with seasonal allergic rhinitis.

pharmacokinetic

absorption

levocetirizine is absorbed quickly and widely after drinking. The peak concentration in plasma is achieved after 0.9 hours of taking the medicine. Stable state achieved after 2 days. The peak concentration is 270 ng/ml and 308 ng/ml after the single dose and the dose repeated every 5 mg once a day. The level of absorption is independent of the dose and is not affected by food, but the peak concentration decreases and the time is slow.

Distribution

levocetirizine is not distributed in tissue, as well as passing through the brain barrier. 90% levocetirizine is attached to plasma proteins. The distribution volume is 0.4 l/kg.

Metabolism

The metabolism of levocetirizine is less than 14% of the dose and so the various results from genetically modified or taken with the ezyme inhibitor are negligible. The metabolic phase includes oxidation, N-and alkylation O- and combined with taurine. The alkylation process through CYP 3A4 intermediaries while oxidation process is related to a lot of CYP and/or unknown.

levocetirizine does not affect CYP isoenzyme 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 at a higher concentration of the peak concentration after use of 5 mg. Due to low metabolism and no metabolic inhibition, the interaction between levocetirizine and other substances is impossible.

Elimination

The half -life of levocetirizine plasma is 7.9 ± 1.9 hours. The clearance is 0.63 ml/min/kg. Levocetirizine and metabolites excreted mainly through urine, accounting for 85.4%. Excretion in feces only accounts for 12.9%.

Before taking Lertazin 5mg Krka tablets treat allergic rhinitis, urticaria (3 blisters x 10 tablets)

How to use

Take the 5 mg lertazin tablet with a glass of water. Can be taken with food or not.

Dosage

Adults and children over 12 years old

recommended dose is 5 mg daily.

Older people

Adjust the dose in patients with medium and severe renal failure.

Children from 6 to 12

Daily dose is 5 mg.

Children under 6 years old

levocetirizine is not recommended for use in patients under 6 years old.

Patients with renal failure

The distance must be adjusted according to the kidney function. The patient's creatinine clearance must be evaluated (CLCR). CLCR (ml/min) is evaluated by determining creatinine in serum.

The formula for determining the creatinine in serum

Adjust the dose in patients with renal failure as follows:

Group

Creatinine clearance (ml/min)

Dosage

≥ 80

1 x 1 tablet daily

50-79

1 x 1 tablet daily

Moderate kidney failure

30-49

1 tablet every 2 days

1 tablet every 3 days

No dose reduction in patients with only liver failure. Patients with liver and kidney failure need to adjust the dose.

Treatment period

Duration of treatment depends on the type of disease, the disease period and the cycle of the disease. For hay sauce, generally the treatment period is 3-6 weeks is enough if exposed to short pollen for about 1 week. There have been clinical evidence of 4 -week treatment regime with Levocetirizine 5 mg film tablets. For chronic eczema and chronic allergic rhinitis, there is clinical data on the treatment time of up to 1 year for Racemic isomer and up to 18 months for patients with itching related to atopic dermatitis.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Sleeping chicken in adults; Initially anxiety and excitement, then sleeping chicken in children.

Treatment

There is no specific antidote with levocetirizine. If overdose occurs, symptomatic treatment and maintenance treatment. Gastric lavage should be considered if the overdose period is short. Eliminate levocetirizine by the method of fertilization is ineffective.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting a dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Lertazin 5 mg, you may experience unwanted effects (ADR).

  • Common (1/100 to dry mouth , headache, fatigue, sleeping chicken. Cardiovascular disorders: Brushing chest drums, astigmatism; Respiratory disorders: shortness of breath; digestive disorders : Nausea; Skin and tissue disorders: edema, itching, skin rash, urticaria; Immune system disorders: Hypersensitivity includes anaphylaxis ; Liver disorders: Hepatitis.

    • Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    contraindicated

    Lertazin 5 mg contraindicated with:

  • Sensitive people with levocetirizine and piperazine derivatives, or other ingredients of the drug.

    Be cautious when using

    Caution in patients with alcohol.

    Lertazin 5 mg film tablets containing lactose. Patients with rare genetic problems of galactose tolerance, lactase lactase deficiency or malcose-galactose absorption should not be taken.

    The ability to drive and operate machinery

    avoid using machinery and driving when using this drug.

    pregnancy and lactation

    levocetirizine does not cause teratogenicity in animals, but there is no full research on pregnant people. Therefore, not for pregnant and lactating women.

    Drug interaction

    There is no study of interactive drugs of levocetirizine (including no studies with CYP3A4 enhancers). Studies on racemic isomers of Cetirizine show that there is no interaction with pseudoephedrine, cimetidine, ketoconazole, erythromycin, azithromycin , glipizide and diazepam .

    .

    Observed, there is a slight decrease in Cetirizine clearance (16%) in the study using multi -dose doses in combination with theophilline (only 400 mg per day). Meanwhile, theophilline tends to not be affected by the drug with Cetirizine. The absorption of levocetirizine is not affected by food but the absorption rate is reduced.

    In some sensitive patients, when using cetirizine or levocetirizine along with alcohol or central neurological inhibitors. Can lead to adverse effects on the central nervous system.

    • Storage

    Leave a cool place, avoid light, temperature below 30⁰C.

    To be out of reach of children.

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