Leukas 4mg oral powder 4mg the prevention and treatment of chronic bronchial asthma (30 packs)

Dosage form 30 package box
Specifications Montelukast

Ingredient

Composition information	Content
Montelukast	4mg

Uses

indications

Leukas 4 mg drug is indicated in the following cases:

Preventive and treat chronic bronchial asthma, including preventive and night asthma symptoms, treat aspirin sensitive asthma, and prevent bronchospasm due to exertion in older patients and children over 6 months of age. and children from 6 months of age and older). (CYSLT1). CYS TYP 1 receptors (CYSLT1) are found in human airfields including plain muscle cells and graphics of the airway, and other inflammatory cells (including EOSIN and myeloma cells).

CYSLT is correlated with asthma pathology. In asthma, Leucotrien intermediaries include a number of effects on the airway such as bronchospasm, affecting mucus secretion, capillary permeability and the addition of Eosin leukemia. In CYSLT allergic rhinitis secreted from the nasal mucosa after exposure to allergens, CYSLT in the nose will increase the resistance in the airway and symptoms of congestion in the nose.

Montelukast has a high affinity and selective selection with CYSLT receptor (this effect is superior to other receptors that are also important in pharmacological such as Prostanoid, Cholinergic or β Adrenergic. Montelukast strongly inhibits the physiological effects of LTC4, LTD4 at CySLT receptors without the intention.

In Hen Montelukast people inhibit cysteinyl leucotrien receptors. Leucotrien in the airway shows the ability to inhibit bronchospasm due to Ltd4 inhalation. With doses of less than 5 mg closed the bronchospasm of Ltd4. Montelukast causes bronchodilator for 2 hours after drinking, these effects are in union with bronchodilator thanks to the use of the agonist β.

Pharmacokinetics

absorption

After drinking Montelukast quickly absorbed and almost completely.

Distribution

drugs attach more than 99% to plasma proteins. The distribution of Montelukast's stable state is 8 - 11 liters. Research on rats with Montelukast marks that there is a minimum distribution through the brain barrier, moreover the concentration of the substance is marked after 24 -hour taken is the minimum of other tissues.

Metabolism

Montelukast is very strong.

Elimination

Montelukast's purification in plasma is 45 ml/minute in healthy people. The drug is excreted almost completely through the bile. The sale time in Montelukast plasma is 2.7 - 5.5 hours in healthy young people. Pharmacokinetics of Montelukast almost linear when taken to the dose of 50 mg.

Before taking Leukas 4mg oral powder 4mg the prevention and treatment of chronic bronchial asthma (30 packs)

How to use

use Leukas 4 mg once a day. To treat asthma, need to take medicine in the evening. With allergic rhinitis, the time to use the drug depends on the needs of each person.

Dosage

Children from 6 months - 2 years old with asthma and/or allergic rhinitis: 4 mg/time/day.

Children from 2 - 5 years old have asthma and/or allergic rhinitis: 4 mg/time/day.

Children from 6 - 14 years old have asthma and/or allergic rhinitis: 5 mg/time/day.

Adults aged 15 and older have asthma and/or allergic rhinitis: 10 mg/time/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

The most common reactions when overdose include abdominal pain, drowsiness, thirst, headache, vomiting and agitation.

Handling

There is no specific information to treat Leukas 4 mg overdose. It is unclear whether Montelukast can be separated through peritoneal or dialysis.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Leukas 4 mg you may experience unwanted effects (ADR).

In general, the drug is well tolerated. The adverse effects are usually mild and often do not need to stop the drug. Hypersensitivity reactions may include anaphylaxis, angioedema, itching, rash, urticaria and very rare seizures, nausea, vomiting, indigestion, diarrhea.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Leukas 4 mg is contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug.

Caution when used

has not been valid when taking Leukas 4 mg in the treatment of acute asthma attacks. Therefore, Leukas should not be taken to treat acute asthma attacks.

may have to reduce corticosteroids gradually with the supervision of a doctor, but not to suddenly replace corticosteroids orally or inhaled with Leukas 4 mg.

When reducing the dose of corticosteroids using systemic sugar in patients using other anti -asthma drugs, including Leucotrien receptor antagonists, it will lead to a rare number of the following cases: Eosin hyperlemen, short breath, heart complications and/or neurological disease sometimes diagnosed as churg strauss is systemic vascular inflammation with EOSIN leukemia. Although the causal relationship has not been identified with Leucotrien receptor antagonists, caution and clinical monitoring should be closely monitored when reducing the dosage of systemic corticosteroids in patients using Leukas 4 mg.

The ability to drive and operate machinery

There is no basis to prove that Montelukast has an influence on the ability to drive and operate machinery.

Pregnancy

has not studied the use of Leukas 4 mg in pregnant women. Only for pregnant women when really necessary.

breastfeeding period

Unknown Leukas 4 mg through breast milk so the mother needs to be cautious when using Leukas 4 mg during breastfeeding.

Drug interaction

can be used Leukas 4 mg with other commonly used drugs in preventive and treating asthma and treatment of allergic rhinitis. In studies on drug interaction, the recommended dose in Montelukast's treatment does not significantly affect the pharmacokinetics of the following drugs: Theophylin, Prednisone, Prednisolone, Ethinyl Estradiol/Norethindrone 35/1), Terfenadine, Digoxin and Warfarin. The area under the curve (AUC) of Montelukast decreased by about 40% in people with phenobarbital. No need to adjust the dose of Leukas 4 mg.

Montelukast does not change the metabolism of drugs that are metabolized through CYP 2C8 enzymes.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

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