Levetstad 500 Stella Treatment of localities (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Levetiracetam

Ingredient

Composition information	Content
Levetiracetam	500mg

Uses

indications

Levetstad drugs are indicated in the following cases:

Affairs

Treatment of local boundary onset epilepsy or not accompanied by secondary comprehensive comprehensive complexity in patients aged 16 and older has just been diagnosed with epilepsy.

Coordination treatment

In the treatment of local bundled epilepsy or not accompanied by secondary comprehensive comprehensive generalization in adults and children aged 12 and older epilepsy.

Pharmacology

levetiracetam is the derivative of pyrrolidone (the S isomers of Alpha-Ethyl-2-OxO-1- Pyrrolidine Acetamide), which are not related to existing anti-epileptic drugs. Levetiracetam prevents epilepsy on a wide range with a local epilepsy model and the whole rawemization on animals without affecting the tendency to cause seizures. Main metabolites are not active.

In humans, the impact on both local epilepsy and all -transparent chemistry (epilepsy/dramatic discharge caused by light) has proved the broad -spectral pharmacological effect of levetiracetam.

Pharmacokinetics

absorption

Levetiracetam is easily absorbed through the gastrointestinal tract with nearly 100%bioavailability. The peak concentration of plasma is achieved after drinking about 1.3 hours and reaching a stable state after 2 days.

Distribution

The ratio of cohesion with plasma proteins is very small, less than 10%. Levetiracetam is excreted through breast milk.

Metabolism

levetiracetam is not much metabolized. About 25% of oral doses are hydroxylated into non -active metabolites.

Elimination

About 95% of oral dose is eliminated in a constant form and metabolites in urine. Selling duration of plasma in adults and children 12 years and older is about 7 hours, in children younger than the selling time may shorter.

Before taking Levetstad 500 Stella Treatment of localities (3 blisters x 10 tablets)

How to use

oral medication with a sufficient amount of water and can be taken during or outside meals.

Dosage

Unit

Patients aged 16 and older: The starting dose of 250 mg 2 times/day and increased to 500 mg 2 times/day after 2 weeks. This dose may continue to increase by 250 mg x 2 times/day every 2 weeks depending on the clinical response. The maximum dose of 1500 mg x 2 times/day.

Coordination treatment

Adults (≥ 18 years old) and adolescents (12-17 years old) weighs ≥ 50 kg: The starting dose of 500 mg x 2 times/day. Depending on the clinical response and tolerance capacity, can increase to 1500 mg 2 times/day. Can add 500 mg x 2 times/day every 2-4 weeks.

Patients ≥ 65 years old and patients with renal function: Daily dose is adjusted by renal function.

Creatinine clearance (ml/min)

Dosage (mg)

The distance between 2 doses (hours)

500–1500

50–79

500–1000

30–49

250–750

250–500

500–1000

24 (*)

Patients with liver failure: No dose adjustment for patients with mild to moderate liver failure. For patients with severe liver failure, creatinine clearance may not fully assess the level of renal failure. Therefore, 50% of the daily maintenance dose should be reduced when creatinine clearance

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

There is no specific antidote for levetiracetam. The main dose treatment is mainly symptomatic treatment and can be hemoglobin. The fertilizer efficiency is about 60% for levetiracetam and 74% for the main metabolites.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Levetstad, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Infection and parasitic infection: Nasomy throat. face.

blood and lymph: platelet reduction, leukemia. Feeling, concentrated disorders. Meet, 1/10000

Infection and parasitic infection: infection. liver.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Levetstad drugs contraindicated in the following case:

Hypersensitivity to levetiracetam, other substances of pyrrolidone or any other ingredient of the drug.

Be cautious when used

Stop drugs: Do not stop the drug suddenly to avoid the risk of increasing seizures. When stopping the drug, levetiracetam should be reduced gradually by 1 g/day, about 2 weeks away.

Patients with renal failure: adjust the dose by renal function.

The suicide trend: suicide, trying to commit suicide or intended to be observed by suicide in patients using anti -epileptic drugs.

The ability to drive and operate machinery

There has been no research on the effect of the drug on the ability to drive and operate machinery. Because sensitivity per individual may vary, some patients may be sleepy or have other symptoms related to the central nervous system, especially when they start treatment or after increasing the dose. Therefore, it is necessary to be cautious for patients when performing jobs that require skills such as driving and operating machinery. Patients should not drive or operate machinery until sure the drug does not affect these activities.

Pregnancy

There are no adequate and controlled studies on pregnant women. Animal studies have shown that Levetiracetam has a development of toxicity. Therefore, levetiracetam should only be used for pregnant women when the benefits bring higher risk to the potential for the fetus.

breastfeeding period

levetiracetam is excreted through breast milk. Due to the potential harmful reactions on breastfed babies, it is necessary to consider the importance of the drug for the mother when deciding to stop the drug or stop breastfeeding.

Drug interaction

There is no clinical significant pharmacy interaction with other anti -epileptic drugs (such as Carbamazepine, Gabapentin, Lamotrigine, Phenobarbital, Phenytoin, Primidone, Valproic Acid). In young children, Levetiracetam clearance increases 22% when used simultaneously with anti -epilepsy drugs that cause liver enzyme induction. However, no dose adjustment.

Food does not change the absorption level but only reduces the rate of levetiracetam absorption.

Cavalry of the drug: Due to no studies on the correspondence of the drug, not mixing this drug with other drugs.

Storage

Store in closed packaging, dry place. The temperature does not exceed 30ºC.

Other drugs

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