Levivina medicine 10mg Ha Tay treat erectile dysfunction (1 blister x 4 tablets)

Dosage form Box of 1 blister x 4 tablets
Specifications Vardenafil

Ingredient

Composition informationContent
Vardenafil10mg

Uses

Indications

Levivina drugs treat erectile dysfunction in adult men (inability to achieve or maintain an erection that is sufficient to satisfy in intercourse).

Pharmacokic

A penis erection is a hemodynamic process based on its plain muscle stretching and its relevant artery. In sexual stimulation, from the nerves in the nitric oxyd (NO) release cave, activate the Ganylat Cyclase enzymes that lead to an increase in the concentration of monophosphate guanosin cyclic (CGMP) in the cave. This will cause smooth muscle relaxation, increasing blood flow into the penis causing erection.

pharmacokinetic

absorption

Vardenafil is quickly absorbed after drinking, CMAX is achieved within 15 minutes in some cases. However, in 90% of cases, CMAX is achieved within 30 to 120 minutes (on average 60 minutes) after drinking.

After taking a dose of Vardenafil, AUC and CMAX increased almost corresponding to the dose, within the recommended dose range from 5mg - 20mg.

When taking Vardenafil with a high fat meal (~ 57% fat), the average CMAX decreases by about 20%, the average TMAX lasts about 1 hour, and AUC is not affected. When taking Vardenafil with a normal meal (- 30% fat), pharmacokinetic parameters are not significantly affected. Therefore, Vardenafil can drink with or not with the same meal.

Distribution

Vardenalil is distributed to tissues, about 95% associated with plasma proteins

Metabolism

Vardenafil is metabolized mainly through the liver by CYP3A4.

The sale time of M1 metabolites is about 4 hours, equivalent to the mother medicine. A part of M1 is associated with glucuronic acid in circulation.

Elimination

After drinking, Vardenafil and metabolites are excreted mainly in feces (about 91% - 95% of oral dose) and a small part of the urine (about 2-6% of oral dose).

Before taking Levivina medicine 10mg Ha Tay treat erectile dysfunction (1 blister x 4 tablets)

How to use

oral medications can be taken with or not at the same meal.

Dosage

The recommended starting dose is 10mg oral before sexual activity about 25 - 60 minutes. Sexual activity can be started after 15 minutes and about 4-5 hours after drinking. The maximum recommended dose is 20mg, at least 5mg, taken 1 time/day. Sexual stimulation is needed to have a natural treatment.

The elderly (over 65 years old): The starting dose should be 5mg.

Children under 18 years of age: Do not use.

Mild and medium liver failure: No dose adjustment, the starting dose should be 5mg, then increase to a maximum dose of 10mg, based on the intake and effectiveness of the drug.

Kidney failure: No dose adjustment in mild renal impairment patients.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Expression

Single -dose research on volunteers, increasing the dose to 80mg Vardenafil/day (film bag) does not cause serious unwanted effects.

When taking Vardenafil at a higher doses and more often than the recommended dosage (40mg, 2 times/day), records some cases of severe back pain, not related to muscle to toxicity or nerves.

Handling

In case of overdose, support treatment if needed. Hemataliosis does not accelerate the removal of drugs because the drug is mainly linked to plasma proteins and is less excreted through urine.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Levivina often has unwanted effects (ADR) such as:

Infections and parasites:

  • Rare: conjunctivitis.

    • The immune system:

  • Uncommon: allergic and angioedema.
  • Rare: allergies.
  • Uncommon: Sleep disorders.
  • Rare: Anxiety.
  • Very common: headache.
  • Common: dizziness, dizziness.
  • Uncommon: visual disorders, eye congestion, unknown colors, pain and discomfort in the eyes, fear of light.
  • Less: tinnitus, dizziness.
  • Unknown: Sudden deafness.
  • Uncommon: chest drum, tachycardia.
  • Rare: myocardial infarction, tachycardia, angina
  • Common: flushing.
  • Common nasal congestion.
  • Common: indigestion.
  • Uncommon: Increasing liver enzymes.
  • Uncommon: Red rash, rash.
  • Rare: light sensitive reactions
  • Uncommon: increased creatin, phosphokinase, muscle pain, muscle tone and cramps.
  • Unknown: Bleeding.

    • Reproduction:

  • Uncommon: Increasing erection.
  • Uncommon: feeling unwell.
  • Rare: chest pain.

    Notify the physician the unwanted effects when using the drug.

    • Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Levivina drugs contraindicated in the following cases:

  • Hypersensitivity to any ingredients of the drug. Contraindicated to use with HIV Protease inhibitors such as indinavir or ritonavir.

    Precautions when used

    Before the beginning of the treatment of erectile dysfunction, it is necessary to consider the patient's cardiovascular condition because of sexual activity related to cardiovascular risk. The medication with vasodilation can reduce mild and transient blood pressure. Patients with left ventricular blood flow such as aortic valve stenosis or stenosis under the aortic valve is notarized, may be sensitive to the effects of vasodilators including phosphodiesterase type 5 inhibitors.

    Do not use drugs in people are recommended not to be sexually active due to cardiovascular disease, those with congenital QT ranges or those who are using IA pills (quinidin, processinide) or group III (amiodaron, sotalol).

    Be cautious about medication in patients with penile anatomical abnormalities (such as folding angle, fibrosis or Peyronie disease) or having a condition that can cause penile pain (sickle cell anemia, multi -tumor or leukemia).

    The safety of the drug has not been fully studied, so it is not advisable to use the drug for the following patients: Severe liver failure, end -stage renal failure that requires dialysis, hypotension, vestibular, genetic retinal degeneration (pigmentitis), patients with bleeding disorders or stomach ulcers are progressing.

    Be cautious to use Vardafil Dong Thoi with Alpha blockers. Do not use the dose of more than 5mg Vardenafil with Alpha blockers. Do not take the drug within 6 hours after taking alpha blockers. The drug should only be used at the same time when the patient has been treated stably with Alpha blockers.

    Do not take the dose of more than 5mg Vardenafil when used simultaneously with erythromycin, ketoconazole and otraconazole, indinavir or ritonavir.

    The effect of drugs on driving and operating machinery

    There is no addiction to the effect of the drug on the ability to drive and operate machinery. The drug can cause dizziness, dizziness, affecting the view, so it should be cautious when used for drivers and operating machinery.

    Use drugs for women during pregnancy and lactation

    drugs are not indicated for women. There is no research data when using drugs in pregnant and lactating women.

    Drug interaction

    Cytochrom P450 (CYP) inhibitors

    The drug is metabolized mainly through CYP3A4 liver and partially through CYP3A5, CYP2C. Therefore, the drug inhibits these enzymes can reduce the clearance of the drug, increase the accumulation of toxic drugs for the liver. Do not use drugs in combination with: cimetidin, erythromycin, ketoconazole, indinavir, ritonavir because of increasing AUC and CMAX of Verdenafil when using simultaneously.

    nitrate, nitric oxidant

    Do not record the risk of hypotension of nitroglycerin (0.4mg) under the tongue when used with Verdenafil (10mg) at different times (24 hours decreases to 1 hour before using nitroglycerin). The hypotension effect of nitrate is closed under the tongue of 0.4mg (used after Vardenafil dose 20mg 1 and 4 hours) is increased. Vardenafil should not be used with nitrates and nitric oxidants.

    Other drugs

    Single -therapy Alpha blockers can reduce blood pressure significantly, especially hypoglycemia and fainting. Hence should not be coordinated.

    Food and food

    Do not take Verdenafil with a high -fat meal because of reducing the absorption rate and average time to reach the maximum concentration in the serum increased by about 60 minutes and the peak in serum decreased by 20%.

    • Storage

    Leave a cool place, avoid light, temperature below 30⁰C.

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