Levodhg 250 drugs treat infections, pneumonia, sinusitis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Levofloxacine

Ingredient

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Composition information	Content
Levofloxacine	250mg

Uses

Indications

Levodhg drugs are indicated in the following cases:

Treatment of infections caused by bacteria sensitive to levofloxacin:

Community pneumonia, prostatitis, skin infections.

Non -complicated urinary tract infections: due to fluoroquinolon antibiotics, including levofloxacin related to serious harmful reactions (see caution when used) and non -complicated urinary tract infections in some patients who can go away on their own, should only use Levofloxacin for patients without other treatment options.

Acute bacterial infections of chronic bronchitis: Due to Fluoroquinolon antibiotics, including levofloxacin related to serious harmful reactions (see caution when used) and acute bacterial infections of chronic bronchitis in some patients who can go away on their own, only use Levofloxacin for non -acute infections. Bacterial properties: Fluoroquinolon antibiotics, including levofloxacin related to serious harmful reactions (see caution when used) and acute sinusitis caused by bacteria in some patients who can go away on their own, should only use Levofloxacin for patients without other treatment options instead.

Pharmacy

levofloxacin is a synthetic antibiotic with a broad spectrum belonging to the Fluoroquinolon group, which has bactericidal effects due to inhibition of Topoisomerase II (DNA-GYRASE) or Topoisomerase IV are essential enzymes of bacteria involved in catalysts, codes DNA of bacteria. Levofloxacin works on multiple gram -negative and gram -positive bacteria. Levofloxacin (as well as sparfloxacin) works on Gram -positive bacteria and anaerobic bacteria than other fluoroquinolon (such as Ciprofloxacin, Enoxacin, LomeFloxacin, Nofloxacin, ofloxacin), however Levofloxacin and Sparfloxacin have Intro -Vitro Aeruginosa is weaker than Ciprofloxacin.

Effects: In vitro sensitive bacteria and bacterial infections:

Gram -negative bacteria: En

Other bacteria: Chlamydia Pneumoniae, Mycoplasma Pneumoniae.

Gram-positive bacteria: Bacillus anthracis, Staphylococcus aureus sensitive methicillin (Meti-S), Staphylococcus coagulase negative methicilin sensitivity, streptococcus pneumoniae.

Anaerobic bacteria: Fusobacterium, peptostreptococcus, propionibacterium.

In vitro intermediary sensitive bacteria:

Gram -positive bacteria: Enterococcus Faecalis.

anaerobic bacteria: Bacteroides Fragilis, Prevotella.

Levofloxacin resistant bacteria:

Gram-positive bacteria: Enterococcus falcium, Staphylococcus aureus meti-B, Staphylococcus coagulase negative meti-r.

Cross resistance: Fluoroquinolone resistance may arise due to mutations in the specified area of DNA Gyrase or Topoisomerase IV. In vitro, crossed between levofloxacin and other fluoroquinolon. Due to the mechanism of action, often without cross -resistant between levofloxacin and other antibiotics. Levofloxacin pharmacokinetics parameters after intravenous and oral route with equivalent dose are almost the same, so it is advisable to prioritize oral and only use the injection route when not drinking.

Food less affects absorption when drinking. Levofloxacin is widely distributed in the body, but it is difficult to penetrate into the cerebrospinal fluid. The ratio of plasma proteins is 30-40%. Levofloxacin is very little metabolized in the body and eliminates almost entirely through the urine in the form of activity, less than 5% of the treatment dose found in urine in the form of metabolic Desmethyl and N-OXID, these metabolites have very little biological activity. Levofloxacin waste time is from 6 to 8 hours and lasts more than 1 person with kidney failure. The drug excreted in urine is about 87% in the form of unchanged and over 12.8%. The drug cannot be removed by hemons or peritoneal.

Before taking Levodhg 250 drugs treat infections, pneumonia, sinusitis (3 blisters x 10 tablets)

How to use

Oral drugs.

Dosage

Respiratory infections

Pneumonia is suffering from the community: 500mg, 1-2 times/day, for 7-14 days.

Sinusitis upper sinusitis: 50mg, 1 time/day, for 10 - 14 days.

Skin infection and subcutaneously

No complications: 500mg, 1 time/day, for 7-10 days.

There are complications: 750mg, 1 time/day, for 7-14 days.

Urinary tract infections

There are complications: 250mg, 1 time/day, for 10 days.

Nephritis - Acute pyelonephritis: 250mg, 1 time/day, for 10 days.

coal disease

Preventive treatment after exposure to coal bacilli: 500mg, 1 time/day, for 8 weeks.

Unsatisfied urinary tract infections

250mg, 1 time/day, for 3 days.

Exacection of chronic bronchitis

500mg, 1 time/day, for 7 days.

acute sinusitis caused by bacteria

500mg, 1 time/day, for 10 - 14 days.

Dosage for patients with renal failure

Urinary tract infections have complications, nephritis - acute pyelonephritis

Creatinine clearance ≥ 20ml/minute: The initial dose is 250mg, maintenance dose 250mg every 24 hours.

Creatinine clearance 10 - 19ml/minute: The initial dose is 250mg, maintenance dose 250mg every 48 hours.

Other indications

Creatinin clearance 50 - 80ml/minute: No dose adjustment.

Creatinine clearance 20 - 49ml/minute: initial dose is 500mg, maintenance dose 250mg every 24 hours.

Creatinine clearance 10 - 19ml/minute: initial dose is 500mg, maintenance dose 125mg every 24 hours.

Hematoma or peritoneal fertilizer: Initial dose 500 mg, maintenance dose 125 mg every 24 hours.

or as directed by the physician.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using LevodHg to treat infection (3 blisters x 10 tablets), you may experience unwanted effects (ADR).

Common

Nausea, diarrhea, liver enzyme, insomnia, headache, irritation.

rarely

Dizziness, stress, excitement, anxiety, abdominal pain, indigestion, vomiting, constipation, hyperlirubin blood, vaginitis, genital candidiasis, itching, rash.

rarely

Hypertension or hypotension, arrhythmia, muscle pain, joint pain, fake colitis, dry mouth, convulsions, abnormal dreams, depression, mental disorders, anaphylaxis.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Levodhg medicine for anti -infections in the following cases:

Hypersensitivity to levofloxacin and other quinolones or any ingredients of the drug.

Epilepsy, deficiency of G6PD, a history of disease in muscle tendons.

Children under 18 years old.

Pregnant women, nursing women.

Be cautious when using

serious harmful reactions are likely to not recover and cause disabilities, including tendonitis, tendon breakdown, peripheral neuropathy and adverse effects on the central nervous system.

Fluoroquinolon antibiotics are associated with serious harmful reactions that can cause disabilities and non -recovery on different organs of the body. These reactions may appear simultaneously on the same patient. Harmful reactions are often recorded including tendonitis, tendon, joint pain, muscle pain, peripheral neuropathy and adverse effects on the central nervous system (hallucinations, anxiety, depression, insomnia, severe headaches and confusion). These reactions may occur within hours to a few weeks after using the drug. Patients at any age or no risk factors that exist before may have these harmful reactions.

Stop using the drug as soon as there are signs or first symptoms of any serious harmful reactions. In addition, avoid using Fluoroquinolon antibiotics for patients who have had serious reactions related to fluoroquinolon.

Patients with central nervous systems such as epilepsy, cerebrovascular sclerosis ...

The drug can cause fake colitis caused by Clostridium difficile. It should be noted that the accurate diagnosis of diarrhea occurs during the time the patient is using antibiotics for appropriate treatment.

There has been a notice that patients using Fluoroquinolon antibiotics, including levofloxacin, appears sensitive to light to severe light.

As well as other quinolones, levofloxacin can cause sugar metabolic disorders, including hyperemia or hypoglycemia often occurs in patients with diabetes using levofloxacin simultaneously with an oral hypoglycemic or with insulin, so it is necessary to monitor blood sugar on the patient.

It is necessary to avoid use on patients with long -term QT, patients with hypokalemia, patients who are using anti -arrhythmia drugs IA (Quinidin, Procainamid ...) or Group III (Amiodaron, Sotalol ...), Precautions when using levofloxacin for patients who are in pulse state of rhythmic rhythms.

The ability to drive and operate machinery

rarely affects the ability to drive and operate machinery.

Pregnancy

Do not use levofloxacin for pregnant women.

Breastfeeding period

Do not breastfeed when using levofloxacin.

Drug interaction

antacid, sucralfate, metal ions, multivitamin can reduce Levofloxacin absorption, so drink at least 2 hours.

Need to closely monitor theophylin concentration and adjust the dose if needed when used simultaneously with levofloxacin.

levofloxacin increases the effects of warfarin and increases the risk of blood sugar disorders when used simultaneously with hypoglycemic drugs, increases the risk of central nerve stimulation and convulsions when used simultaneously with nonsteroidal anti -inflammatory drugs.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

Other drugs

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