Levodhg 500 drugs treat infections, pneumonia, prostatitis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Levofloxacin

Ingredient

Composition information	Content
Levofloxacin	500mg

Uses

indications

Levodhg medicine indicated treatment in the following cases:

Treatment of infections caused by bacteria sensitive to levofloxacin

Community pneumonia, prostatitis, skin infections.

Treatment of urinary tract infections is not complicated

Do levofloxacin is associated with serious harmful reactions and urinary tract infections are not complicated in some patients who can go away on their own, only levofloxacin should be used for patients without other treatment options instead.

Treatment of acute bacterial infections of chronic bronchitis

Due to levofloxacin is associated with serious harmful reactions and acute bacterial infections of chronic bronchitis in some patients who can go away on their own, only levofloxacin should be used for patients who do not have other replacement treatment options.

Treatment of sinusitis acute bacteria

Do levofloxacin is associated with serious harmful reactions and acute sinusitis caused by bacteria in some patients who can go away on their own, only levofloxacin should be used for patients without other treatment options instead.

Pharmacology

levofloxacin is a synthetic antibiotic with a broad spectrum belonging to the Fluoroquinolon group, which has bactericidal effects due to inhibiting bacterial DNA synthesis. Levofloxacin works on many Gram -negative and Gram -positive bacteria such as staphylococcus aureus, streptococcal and even pneumococcal, intestinal bacteria, Haemophilus influenzae, especially on Gram -positive and anaerobic bacteria than other fluoroquinolones. Often there is no cross -resistance between levofloxacin and other antibiotics.

Pharmacokinetics

absorption

Levofloxacin is absorbed quickly and almost completely through the digestive tract, absolutely used by approximately 99%. Levofloxacin pharmacokinetics parameters after intravenous and oral route with the same dose are almost the same, so they can use these two lines instead of each other.

Distribution

levofloxacin is widely distributed in the body but difficult to penetrate into the cerebrospinal fluid.

Metabolism

levofloxacin is very little metabolized in the body.

Elimination

levofloxacin eliminates almost entirely through the urine in the form of activity. Levofloxacin waste time is from 6 to 8 hours and lasts longer in kidney failure.

Before taking Levodhg 500 drugs treat infections, pneumonia, prostatitis (3 blisters x 10 tablets)

How to use

Levodhg drug used oral.

Dosage

Respiratory infections:

Pneumonia is suffering from the community: 500 mg, 1-2 times/day, for 7-14 days.

High -level sinusitis: 500 mg, 1 time/day, for 10 - 14 days.

Skin infection and subcutaneous organization:

No complications: 500 mg, 1 time/day, for 7-10 days.

There are complications: 750 mg, 1 time/day, for 7-14 days.

Urinary tract infections:

There are complications: 250 mg, 1 time/day, for 10 days.

Nephritis - Acute pyelonephritis: 250 mg, 1 time/day, for 10 days.

Inhalation:

Preventive treatment after exposure to coal bacilli: 500 mg, 1 time/day, for 8 weeks.

Non -complicated urinary tract infections: 250 mg, 1 time/day, for 3 days.

Exacerbats of chronic bronchitis: 500 mg, 1 time/day, for 7 days.

Acute sinusitis caused by bacteria: 500 mg, 1 time/day, for 10 - 14 days.

Dosage for patients with renal failure:

Urinary tract infections have complications, nephritis - acute pyelonephritis:

Creatinine clearance> 20 ml/min: the initial dose is 250 mg, maintenance dose 250 mg every 24 hours.

Creatinine clearance 10 - 19 ml/minute: The initial dose is 250 mg, maintenance dose 250 mg every 48 hours.

Other indications:

Creatinin clearance 50 - 80 ml/minute: No dose adjustment.

Creatinine clearance 20 - 49 ml/minute: The initial dose is 500 mg, maintenance dose 250 mg every 24 hours.

Creatinine clearance 10 - 19 ml/minute: The initial dose is 500 mg, maintenance dose 125 mg every 24 hours.

Hematoma or peritoneal fertilizer continuously: Initial dose 500 mg, maintenance dose 125 mg every 24 hours.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Levodhg, you may experience some unwanted effects.

Common, ADR> 1/100

Digestive system: Nausea, diarrhea.

Liver: Increased liver enzyme

Nervous system: Insomnia, headache.

General disorder: irritation of the injection place.

Uncommon, 1/1000

Eyes: Flowers lost

Mental: Stress, excitement, anxiety.

Digestive system: abdominal pain, flatulence, indigestion, vomiting, constipation.

Liver system: Hypergestic blood bilirubin

Bacterial infection and fungal infection: Vaginitis, genital candidiasis.

Skin and soft tissue: itching, rash.

Rare, ADR

Vascular blood: Increase or hypotension

Cardiovascular system: arrhythmia

musculoskeletal and connective tissue: muscle pain, joint pain

Digestive system: fake, dry, mouth colitis

Nervous system: convulsions.

Mental: abnormal dreams, depression, mental disorders

The immune system: Anaphylaxis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

contraindicated

levofloxacin contraindicated in the following cases:

Hypersensitivity to levofloxacin and other quinolones or any ingredients of the drug.

epilepsy, deficiency of G6PD, a history of disease in muscle tendons.

Children under 18 years old.

Pregnant women, breastfeeding women.

Caution when using

serious harmful reactions are likely to not recover and cause disabilities including tendonitis, tendon breakdown, peripheral neuropathy and adverse effects on the central nervous system.

Fluoroquinolon antibiotics are associated with serious harmful reactions that can cause disabilities and non -recovery on different organs of the body. These reactions may appear simultaneously on the same patient. Harmful reactions are often recorded including tendonitis, tendon, joint pain, muscle pain, peripheral neuropathy and adverse effects on the central nervous system (hallucinations, anxiety, depression, insomnia, severe headaches and confusion).

These reactions can occur within hours to a few weeks after using the drug. Patients at any age or no risk factors in the past may have these harmful reactions.

Stop using the drug as soon as there are signs or first symptoms of any serious harmful reactions. In addition, avoid using Fluoroquinolon antibiotics for patients who have had serious reactions related to fluoroquinolon.

Patients with central nervous systems such as epilepsy, cerebrovascular sclerosis ...

The drug can cause fake colitis caused by Clostridium difficile. It should be noted that the accurate diagnosis of diarrhea occurs during the time the patient is using antibiotics for appropriate treatment.

There has been a notice that patients using Fluoroquinolon antibiotics, including levofloxacin, appears sensitive to light to severe light.

As well as other quinolones, levofloxacin can cause sugar metabolic disorders, including hyperemia or hypoglycemia often occurs in patients with diabetes using levofloxacin simultaneously with an oral hypoglycemic or with insulin, so it is necessary to monitor blood sugar on the patient.

It is necessary to avoid use in patients with long -term QT, patients with hypokalemia, patients who are using anti -arrhythmic drugs IA (Quinidin, Procainamid ...) or Group III ( Amiodaron , Sotalol ...), Precautions when using levofloxacin for patients who are in disruptive conditions such as rhythmic rhythm.

The ability to drive and operate machinery

rarely affects the ability to drive and operate machinery.

Pregnancy

Do not use levofloxacin for pregnant women.

Breastfeeding period

Do not breastfeed when using levofloxacin.

Drug interaction

Antacid, sucralfate, metal ions, Multivitamin can reduce the absorption of Levofloxacin, so drink at least 2 hours.

Need to closely monitor theophylin concentration and adjust the dose if needed when used simultaneously with levofloxacin.

levofloxacin increases the effects of warfarin and increases the risk of blood sugar disorders when used simultaneously with hypoglycemic drugs, increases the risk of central nerve stimulation and convulsions when used simultaneously with nonsteroidal anti -inflammatory drugs.

Storage

Store in a dry place, the temperature does not exceed 30 ° C, avoiding light.

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