Levofloxacin Kabi 100ml Fresenius Kabi treatment, pneumonia treatment

Dosage form Bottle x 100ml
Specifications Levofloxacin
Ingredient Fresenius Kabi

Ingredient

Thành phần cho 100ml

Composition information	Content
Levofloxacin	500mg

Uses

indications

Kabi levofloxacin pills are indicated in the following cases:

Treatment of infections caused by bacteria sensitive to levofloxacin such as:

Pneumonia is suffering from the community.

Prostatitis. In case of caution when taking the drug) and the urinary tract infection there is no signs in some patients who can go away on their own, only use Levofloxacin Kabi for patients who do not have other options for replacement. Drugs) and acute bacterial infections of chronic bronchitis in some patients who can go away on their own, only levofloxacin kabi should be used for patients who do not have other replacement treatment options. Bacteria in some patients can go away on their own, only Levofloxacin Kabi should be used for patients who do not have other replacement treatment options.

Pharmacokology

Pharmacological group: Quinolon antibiotics, fluoroquinolon.

mā ATC: Jo1ma12.

As well as other fluoroquinolon, levofloxacin has bactericidal effects due to inhibiting the Topoisomerase II (DNA-GYRASE) and/or Topoisomerase IV are essential enzymes of the catalyst participating in the process of copying, transcription and DNA repair of bacteria. Levofloxacin is the isomorphic S-(-)-Isomer of Ofloxacin, it has a strong bactericidal effect of 8-128 times higher than D-Isomer and the effect is about twice as strongly than Ofloxacin Racemic. Levofloxacin, as well as other fluoroquinolones are broad-spectrum antibiotics, acting on multiple gram (+) and gram bacteria strains (-). Levofloxacin (as well as sparfloxacin) works on Gram (+) bacteria and aerobic bacteria better than other fluoroquinolones (such as ciprofloxacin, enoxacin, lomefloxacin, norfloxacin, ofloxacin). However, Levofloxacin and Sparfloxacin have the effect of printing Vitro on Pseudomonas Aeruginosa weaker than Ciprofloxacin.

spectrum effect:

In vitro sensitive bacteria and clinical infections:

Gram-demand bacteria (-): En Other: Chlamydia pneumoniae, Mycoplasma pneumoniae. Pneumoniae.

Anaerobic bacteria: Propionibacterium. Fusobacterium, peptostreptococcus.

Gram (+) bacteria: Enterococcus Faecalis.

Gram (+) bacterial bacteria: Enterococcus Faecium, Staphylococcus aureus meti-r, Staphylococcus coagulase negative meti-r. Due to the mechanism of action, often without diagonal resistance between levofloxacin and other antibiotics. The ratio of plasma proteins is 30-40%

Levofloxacin is very less metabolized in the body and eliminates almost entirely through the urine in the active form, only less than 5% of the treatment dose found in the urine in the form of metabolic Desmethyl and N-OXID, these metabolites have very little biological activity.

Levofloxacin's waste time is from 6 to 8 hours, prolonged in people with renal failure. The drug excreted in urine is about 87% in the form of unchanged and crossing about 12.8%. The drug cannot be removed by hemons or peritoneal.

Before taking Levofloxacin Kabi 100ml Fresenius Kabi treatment, pneumonia treatment

How to use

levofloxacin is only used by slow intravenous, fast transmission will lead to the risk of lowering blood pressure. A transmission line.

Pneumonia is suffering from the community: 500 mg x 1 time/day x 7-14 days.

Prostatitis: 500 mg x 1 time/day x 28 days. Urinary tract bacteria have no complications:: 250 mg x 1 time/day x 3 days

Acute bacterial infection of chronic bronchitis: 500 mg x 1 time/day x 7 days

acute sinusitis caused by bacteria: 500 mg x 1 time/day x 10-14 days. Creatinine (ml/minute) initial dose Now

10 - 19 250 mg 250 mg Every 48 GILL Mg 250 mg Every 24 hours 10 - 19 500 mg 125 mg every 24 hours

Blood split 500 mg 125 mg every 24 hours Customs 500 mg 125 mg every 24 hours

Dosage for liver failure: No need to adjust the dose

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Toxic studies on mice and dogs, when clinical signs after using the only high doses Levofloxacin such as loss of air conditioning, eyelid prolapse, reduced exercise, exhaustion, shortness of breath, shudder, convulsions. Intravenous injection exceeds 250 mg/kg has caused a significant mortality rate in rodents.

When an acute overdose is overdose, it is necessary to treat symptoms and closely monitor. Hematitis and peritoneal fertilizer are not effective to remove levofloxacin from the body. Monitor the electrocardiogram of the medicine that extends the QT range.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using the drug often has unwanted effects (ADR) such as:

Unwanted effects during the circulation are listed in the following table according to the severity:

Common (1/100 Uncommon (1/1000 rarely (ADR Pepper Abdominal pain, flatulence, indigestion, vomiting, constipation fake colitis, dry mouth, gastritis, tongue edema The head

dizzy, stressed, agitated, worried

convulsions, abnormal dreams, depression, mental disorders

da irritated in the injection place, itching, skin rod Vaginal inflammation, genital candidiasis Bone myelitis, Achille tendonitis

allergies

Need to stop levofloxacin in the following cases: Start there are signs of multi or any signs of sensitive reaction or ADR on the central nervous system. It is necessary to monitor patients to detect fake colitis and take appropriate treatments when diarrhea appears while using levofloxacin. When signs of tendonitis appear to stop immediately, the two are close to the heel to rest with the appropriate fixed tools or heel brace and specialized consultation.

Notify the physician with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Levofloxacin Kabi is contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug. force.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Special tendonitis is near the heel (Achille), which can lead to tendons. This complication may appear at the first 48 hours after starting the medication and may be both sides. The tendonitis occurs mainly in risky subjects: people over 65 years old, using corticosteroids (including inhalation lines). These two factors increase the risk of tendonitis. In order to prevent daily dosage of drugs in older patients according to glomerular filtration level. Army illness because the manifestations may be worse. The first dose. If these adverse reactions occur while using levofloxacin, medication is needed and have appropriate symptom management measures. Caution should be used for patients with central neuropathic diseases such as epilepsy, brain vascular sclerosis because they may increase the risk of convulsions. It is necessary to stop the drug as soon as there are the first signs of sensitive reaction and apply appropriate treatment. It should be noted to accurately diagnose diarrhea cases during the time when the patient is using antibiotics for appropriate treatment. Patients should avoid direct contact with light during treatment and 48 hours after treatment. Therefore, it is necessary to monitor blood sugar on this patient. If hypoglycemia occurs, levofloxacin should be discontinued and properly treated. (Quinidin, Procainamid ...) or Group III (Amiodaron, Sotalol ...); Be careful when using levofloxacin for patients who are in the provinces of the pace of rhythms such as slow rhythm and acute myocardial ischemia. Causing disability and non -recovery on different organs of the body. These reactions may appear simultaneously on the same patient. Harmful reactions are often recorded including tendonitis, tendon, joint pain, muscle pain, peripheral neuropathy and adverse effects on the central nervous system (hallucinations, anxiety, depression, insomnia, severe headache and confusion). These reactions may occur within hours to a few weeks after using the drug. Patients at any age or no risk factors that exist before may experience the harmful reactions. In addition, avoid using Fluoroquinolon antibiotics for patients who have experienced serious reactions related to fluoroquinolon.

The effect of the drug on the ability to drive and operate machinery

Because the drug has the effect on the central nervous system, it does not drive and operate the machine while taking the drug.

Use drugs for women during pregnancy and lactation

Pregnant women:

Do not use levofloxacin for pregnant women.

breastfeeding women:

Do not breastfeed when using levofloxacin.

Interactive drug

The drugs that extend the QT interval: have the effect of the syllable to extend the QT range. Avoid simultaneous use of levofloxacin with IA anti -arrhythmic drugs (for example: Quinidin, processine) or group III (for example: Amiodaron, Sotalol). Levofloxacin with corticosteroids increases the risk of nearing severe disorders (tendonitis, tendon), especially in the elderly over 60 years old. Need to be careful when using these two drugs. However, due to plasma concentrations and AUC Theophylin is often increased when used simultaneously with another quinolon, it is still necessary to closely monitor theophylin concentration and adjust the dose if needed when used simultaneously with levofloxacin. This. However, the plasma concentration of these drugs should be controlled when used simultaneously with levofloxacin. Conscious. Should use the more specific method to determine the positive opiat amount.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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