Levomepromazin 25mg Danapha tablets treat mental illnesses (100 tablets)

Dosage form Box of 100 capsules
Specifications Levomepromazin

Ingredient

Composition information	Content
Levomepromazin	25mg

Uses

indications

levomepromazin 25 mg is indicated in the following cases:

schizophrenic mental illness, cyclical psychosis, stage psychosis manic , physical psychosis. Personal disorders have excessive aggressive attitudes and outward behaviors. However, some central effects of chlorpromazin have been amplified in levomepromazin. Sedative effects, the ability to enhance the effect of sleeping and relieving more pain.

Dynamic pharmacokinetics

After taking the drug, the peak concentration in plasma reaches from 1 to 4 hours. About 50% of oral medications in the whole body. Levomepromazin metabolizes the liver into sulfoxid and glucuronic complex and excreted the urine in the form of those substances. A small amount of non -changing excretory drugs on feces and urine. Half lifetime of serum for about 20 hours. The metabolites are also effective but inferior to whole drugs. Relatively slow excretion and metabolites remain in urine for up to 1 week after taking a single dose.

Before taking Levomepromazin 25mg Danapha tablets treat mental illnesses (100 tablets)

How to use

oral medication.

Dosage

conventional dose in adults and teenagers

Mental disorders and severe pain: Initial oral: 50 - 75 mg (base)/day divided into 2 or 3 times, taken at meals, increasing dose if needed and withstand the drug.

If the initial dose takes 100 - 200 mg/day, the patient must stay in bed for the first few days to avoid lower blood pressure. It may take a dose of 1 g or more every day to treat severe mental disorders.

Normal doses in children

Mental or pain or sedation: Initial dose: 0.25 mg (base)/kg/day divided into 2 or 3 times to drink with meals; The dose increases if necessary and tolerated. The dose must not exceed 40 mg/day in children under 12 years of age.

Common doses in the elderly

1/2 usual dose in adults.

Patients with physical mental illness or a state of mental illness

Must use the initial dose equal to 1/3 or 1/2 of the usual dose in adults. The dose increases gradually but not too early 2-3 days, so 7-10 days if possible.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Central neurological inhibition is the most dominant symptom. Lost air conditioning, dizziness, sleep, unconsciousness, convulsions, respiratory inhibitors. Symptoms of foreign tower can occur late. Sinus tachycardia, long time q - t, atrial clog, qrs wide, but rarely encounter severe ventricular arrhythmia. Reducing blood pressure. Malignant syndrome caused by neurium.

Treatment

Stomach was with activated carbon. Respiratory support and adjust the alkaline balance. Anti -convulsions: Diazepam 10 - 20 mg for adults, 0.1 - 0.2 mg/kg for children. Symptoms of the pagoda, giving biperiden 2 - 4 mg, children 0.04 mg/kg intramuscularly 30 minutes apart. Monitor electrocardiograms. Anti -arrhythmia, use thioridazin. Hypotension, intravenous infusion and dopamine, noradrenalin, dobutamin.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Levomepromazin 25 mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Cardiovascular: hypotension Standing, fast heartbeat, chest drum.

Neurological: Surgery syndrome includes acute muscle disorders, standing still, syndrome Parkinson , tremor around the mouth, late dysplasia (after long -term treatment). Skin: Light sensitivity, skin rash, hypersensitivity reaction (urticaria, chart, hemorrhage or edema).

Respiratory: Nasal congestion (stuffy nose).

Uncommon, 1/1000

Eyes: regulating disorders.

Endocrine and metabolism: big breasts in the South, changes in sexuality, weight gain.

Urinary, genital: Difficult to urinate. digestive: Nausea, vomiting, stomach pain. Neurosurgery: Run.

Rare, ADR

Neurological: Malignant syndrome caused by neuroleptic, body temperature disorders, lowering the threshold of seizures.

Skin: Dark skin variables (gray chromosomes - blue due to long -term use).

Endocrine and metabolism: Large milk.

urinary and genitals: impotence .

Hematology: Loss of granulocytes, leukopenia. liver: jaundice of cholestasis, liver poisoning.

Eyes: pigmentation disease.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Levomepromazin 25 mg contraindicated in the following cases:

hypersensitivity to phenothiazin.

Kidney, heart or severe liver disease, or a history of convulsions.

Overdose of Barbiturat, Opiat or alcohol.

leukopenia and a history of granulocytes.

Myasthenia disease.

coma.

Caution when using

Because levomepromazin can cause significant hypotension, patients who use drugs must be in bed or must be closely monitored at least 6-12 hours after each drink first doses.

Be cautious when taking medication for elderly people or depression people with heart disease because of the risk of severe hypotension. In these people, it is necessary to reduce the first dose and may increase gradually if needed while regularly checking vessels and blood pressure.

For long -term drug users, blood tests and liver tests must be periodically paid, because there may be heavy hematological and liver side effects.

Be cautious when indicated for mental disorders.

The ability to drive and operate machinery

Need to use the drug cautious in the person who is driving and operating machinery because the drug can cause drowsiness.

Pregnancy

Do not use drugs for patients in the last 3 months of pregnancy because of the increased risk of unwanted reactions of nerves and jaundice for babies. However, the drug can be used during labor because it rarely occurs uterine contractions.

The period of breastfeeding

With the dose to relieve pain during labor, breast milk may contain a negligible amount of drugs. But in terms of concentration and dosage in young children, it is likely that there is no risk for children.

Drug interaction

When used simultaneously with:

Hematoplastic drugs: The risk of increased hypotension. Histamine or alcohol. Be cautious when used with these drugs to avoid overdose.

Storage

Leave the medicine in a dry, airy place, avoid light, temperatures below 30 ° C.

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