Levoquin 500 pymepharco treatments for infections (2 blisters x 4 tablets)

Dosage form Box of 2 blisters x 4 tablets
Specifications Levofloxacin

Ingredient

Composition information	Content
Levofloxacin	500mg

Uses

indications

Levoquin 500 is indicated for treatment of infections caused by sensitive bacteria:

acute sinusitis .

The acute drama of chronic bronchitis.

Pneumonia has a community.

Prostatitis .

Urinary tract infections have complications or not, including nephritis - pyelonephritis.

Skin infections and soft tissues have complications or not.

Preventive after exposure and thorough treatment of coal diseases.

Pharmacy

levofloxacin is an antibiotic antibiotic antibacterial group. Levofloxacin inhibits the synthesis of bacteria DNA by acting on the Gyrase and/or TopoISO - Merase IV complex are essential enzymes of bacteria involved in the catalyst during the bacterial copy, code and DNA repair process. Levofloxacin has high bactericidal in vitro. Wide antibacterial spectrum, including many Gram -positive, gram -negative and anaerobic bacteria.

antibacterial spectrum:

Gram (-) bacterial bacteria: En Gram (+): Bacillus anthracis, Staphylococcus aureus (methicillin sensitivity), Staphylococcus coagulase negative (methicillin sensitivity), Streptococcuspneumoniae. Propionibacterium.

Other bacteria: chlamydiapneumoniae, mycoplasmapneumoniae.

Levofloxacin resistant bacteria: Enterococcusfusfiecium, Staphylococcus aureus (methicillin resistance), staphylococcus coagulase negative (methicillin resistance).

Pharmacokinetics

absorption

After drinking, Levofloxacin is absorbed almost completely. Peak concentration in plasma is achieved after 1-2 hours. Absolute bioavailability is about 99%. Food is less influential on the absorption of levofloxacin.

Distribution

about 30-40% eavofloxacin is attached to plasma proteins. Levofloxacin is widely distributed in the body but difficult to penetrate into the cerebrospinal fluid.

Metabolism

levofloxacin is very little metabolized in the body and eliminates almost entirely through the urine in the active form.

Elimination

Levofloxacin waste time is about 6 - 8 hours, prolonged in patients with renal failure.

Before taking Levoquin 500 pymepharco treatments for infections (2 blisters x 4 tablets)

How to use

levoquin 500 Used orally.

The time when drinking levofloxacin does not depend on meals (can be taken in or away from meals). Do not use aluminum and magnesi antacids, preparations containing heavy metals such as iron and zinc, sucralfat, and didanosin (because in the form of this drug contains antacid) within 2 hours before and after taking levofloxacin.

Dosage

acute sinusitis

Take 500 mg, 1 time/day, used for 10 to 14 days.

Take 500 mg, 1 time/day, used for 7 days.

Take 500 mg, 1-2 times/day, used for 7 to 14 days.

There are complications: Take 250 mg, 1 time/day, used for 10 days.

Pyelonephritis - Pyelonephritis: Take 250 mg, 1 time/day, used for 10 days.

No complications: Take 250 mg, 1 time/day, used for 3 days.

Skin infections and soft tissue

There are complications: Take 750 mg, 1 time/day, used for 7 to 14 days.

No complications: Take 500 mg, 1 time/day, used for 7 to 10 days.

Coal disease

Preventive treatment after exposure to coal bacilli: 500 mg, 1 time/day, used for 8 weeks.

Treatment of coal diseases: intravenously, then take the drug when the patient's condition is allowed, the dose of 500 mg, 1 time/day, for 8 weeks.

Prostatitis

500mg/24 hours, intravenously. After a few days, you can switch to drink.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?According to animal toxicity studies and clinical pharmaceutical research conducted at the dose exceeding the treatment dose, the most important signs that can be seen after an acute Levofloxacin overdose are symptoms of the central nervous system such as confusion, dizziness, consciousness, convulsions, prolonging QT interval on electrocardiograms, gastric reactions such as nausea and mucosa.

Effects on the central nervous system have been observed including confusion, convulsions, hallucinations, tremors.

How to handle

There is no specific antidote. If overdose occurs, symptomatic treatment should be treated. Monitor the electrocardiogram because the drug causes the interval of QT. Anti -acid drugs can be used to protect the stomach lining.

Hemolysis, including peritoneal fertilizer and continuous peritoneal, ineffective levofloxacin from the body.

What to do when you forget a dose?

If you forget to take a dose, drink as soon as you remember. If the time is close to the next medication, skip the forgotten dose and take the next dose at the usual time. Do not use double dose to compensate for the forgotten dose.

Side Effects

When using levoquin 500 you may experience unwanted effects (ADR).

Common side effects such as nausea, diarrhea, liver enzyme, sleeping eyes, headache.

rarely

Dizziness, stress, anxiety, abdominal pain, this is slightly, indigestion, vomiting, constipation, increased blood bilirubin, vaginitis, genital candidiasis, rash.

rarely

Increase or lower blood pressure, arrhythmia, fake colitis, dry mouth, gastritis, tongue edema, joint pain, muscle weakness, muscle pain, osteomyelitis, Achille tendonitis , convulsions, abnormal dreams, depression, mental disorders, quinck, anaphylaxis, Steven - Johnson and Lyelle syndrome.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Levoquin 500 drug contraindicated in the following cases:

Not for patients allergic to levofloxacin, with other quinolones or any ingredients of the drug.

Patients with epilepsy.

Patients with a history of muscle tendon due to the use of fluoroquinolon.

Children or teenagers under 18 years old.

Be cautious when used

Achille tendonitis, which can lead to tendons. This complication may appear at the first 48 hours, after starting the medication and may be both sides. The tendonitis occurs mainly in people at risk: people over 60 years old, using high -dose levofloxacin, using corticosteroids (including inhalation lines). These factors increase the risk of tendonitis.

To prevent, need to adjust the daily dosage of drugs in older patients according to glomerular filtration level. Levofloxacin can cause cartilage degeneration in gravity joints on many young animals, so levofloxacin should not be used for children under 18 years old. Be careful in patients with myasthenia gravis because the manifestations may worsen.

Be cautious when used for patients with central neuropathy diseases such as epilepsy, brain vasoconstriction ... because they may increase the risk of seizures. Sensitive reaction: Hypersensitivity reaction with many different clinical manifestations, even anaphylaxis when using quinolones including levofloxacin has been notified.

It is necessary to stop the drug as soon as there are the first signs of sensitive reactions and apply appropriate management measures. Clostridium difficile colitis may occur at mild to life -threatening levels. It should be noted that the accurate diagnosis of diarrhea occurs during the time the patient is using antibiotics for appropriate treatment.

Sensitive to light may occur, so patients should avoid direct light exposure during treatment and 48 hours after treatment. Blood glucose monitoring in diabetes patients should be used when used simultaneously levofloxacin with hypoglycemic drugs or with insulin. Precautions when taking patients with long -term QT patients, patients with hypokalemia, patients are using anti -arrhyths group 1A (quinidin, processaamid, ...) or group III (amiodaron, sotalol, ...), patients with acute myocardial ischemia and patients are in pulse condition such as rhythmic rhythm.

Patients with glucose enzyme deficiency - 6 phosphate dehydrogenase (G6PD): Hemolysis reaction may occur when using quinolones for patients with G6PD deficiency. Therefore, it is necessary to monitor the possibility of hemolysis if it is necessary to use levofloxacin for this object.

The ability to drive and operate machinery

The drug can affect the ability to drive and operate machinery. Therefore, be careful before driving and operating machinery when taking the drug.

Pregnancy

Do not use drugs in pregnant women.

The period of breastfeeding

has not measured the level of levofloxacin in breast milk, but based on the ability to distribute into levofloxacin's milk, it can be predicted that Levofloxacin is also distributed into breast milk. Because the drug has many risks of articular cartilage damage on young children, not breastfeeding when using levofloxacin.

Drug interaction

antacid, sucralfate, metal ions, multivitamin: When used simultaneously, it can reduce the absorption of levofloxacin, need to take these drugs away from Levofloxacin at least 2 hours.

Hypoglycemic drugs: Concomitance with levofloxacin may increase the risk of blood sugar disorders, need closely monitoring.

Theophylllin: Need to closely monitor theophylllin concentration and adjust the dose if necessary when used simultaneously with levofloxacin.

warfarin: Need to monitor blood clotting indicators when used simultaneously with levofloxacin.

Steroid anti -inflammatory drugs: capable of increasing the risk of central nerve stimulation and convulsions when used simultaneously with levofloxacin.

Storage

Cool dry place, avoid light, at temperatures below 30ºC.

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